STRINGSTRING
LOC101093938 LOC101093938 WNT1 WNT1 BMPER BMPER BCL9L BCL9L NODAL NODAL FBXL15 FBXL15 ENG ENG NANOG NANOG SNW1 SNW1 PDPK1 PDPK1 INHBE INHBE PBLD PBLD IL17RD IL17RD BMP5 BMP5 ITGA3 ITGA3 SNX25 SNX25 EP300 EP300 CRB2 CRB2 ABL1 ABL1 LEMD2 LEMD2 TGFB1 TGFB1 UBE2O UBE2O HFE HFE NRROS NRROS LRP2 LRP2 CREBBP CREBBP INHA INHA GIPC3 GIPC3 CSNK2B CSNK2B SPRY2 SPRY2 CHRD CHRD BMP3 BMP3 IL17F IL17F ZNF451 ZNF451 TGFB1I1 TGFB1I1 PIN1 PIN1 NOTCH2 NOTCH2 KDR KDR GDF15 GDF15 GDF3 GDF3 CRIM1 CRIM1 MPP5 MPP5 VASN VASN SLC2A10 SLC2A10 THBS1 THBS1 CILP CILP HSPA5 HSPA5 TGFBR3 TGFBR3 SMAD6 SMAD6 SPRED1 SPRED1 TBX20 TBX20 SORL1 SORL1 GIPC1 GIPC1 SPRY1 SPRY1 STK11 STK11 TFAP2E TFAP2E BMPR2 BMPR2 TGFB3 TGFB3 CILP2 CILP2 SMURF1 SMURF1 CDH5-2 CDH5-2 HTRA3 HTRA3 FBN1 FBN1 ILK ILK TFAP2B TFAP2B LEMD3 LEMD3 FERMT1 FERMT1 GDF11 GDF11 LOC101084379 LOC101084379 ASPN ASPN CCN1 CCN1 UBL3 UBL3 ING2 ING2 SMURF2 SMURF2 EMILIN1 EMILIN1 NOTCH1 NOTCH1 SKI SKI WFIKKN2 WFIKKN2 TWSG1 TWSG1 ACVR1B ACVR1B LATS1 LATS1 FGF9 FGF9 SDCBP SDCBP LY6G5B LY6G5B CITED2 CITED2 LDLRAD4 LDLRAD4 TNFAIP6 TNFAIP6 CD109 CD109 BMPR1A BMPR1A GDF6 GDF6 BMP6 BMP6 BMP10 BMP10 GDF10 GDF10 HIPK2 HIPK2 SULF1 SULF1 INHBC INHBC SPART SPART SIRT1 SIRT1 VWC2L VWC2L AXIN1 AXIN1 ONECUT2 ONECUT2 CHST11 CHST11 CAV1 CAV1 ZEB1 ZEB1 CAV3 CAV3 RNF111 RNF111 BMP2 BMP2 GIPC2 GIPC2 SFRP5 SFRP5 SMAD4 SMAD4 CITED1 CITED1 FGF10 FGF10 RNF165 RNF165 LOC101097198 LOC101097198 NKX2-1 NKX2-1 ENSFCAP00000033708 ENSFCAP00000033708 NPNT NPNT FST FST SMAD3 SMAD3 EID2 EID2 SFRP1 SFRP1 GDF5 GDF5 NEO1 NEO1 CTDSPL2 CTDSPL2 NBL1 NBL1 LINGO3 LINGO3 SKIL SKIL PELO PELO ACVRL1 ACVRL1 ACVR2A ACVR2A VEPH1 VEPH1 SOSTDC1 SOSTDC1 ZNF703 ZNF703 SFRP2 SFRP2 TMPRSS6 TMPRSS6 FSTL1 FSTL1 INHBB INHBB ZBTB7A ZBTB7A LRG1 LRG1 BMP8A BMP8A GPC3 GPC3 HES5 HES5 SH2B1 SH2B1 SCUBE3 SCUBE3 TGFBR3L TGFBR3L CHRDL1 CHRDL1 LTBP1 LTBP1 PMEPA1 PMEPA1 TRIM33 TRIM33 BAMBI BAMBI FLCN FLCN SMAD7 SMAD7 WFIKKN1 WFIKKN1 ADAMTSL2 ADAMTSL2 SKOR1 SKOR1 FAM89B FAM89B RBPMS RBPMS SKOR2 SKOR2 DAND5 DAND5 SOST SOST INHBA INHBA TP53 TP53 LOC101092676 LOC101092676 GREM2 GREM2 CDH5 CDH5 NOG NOG UCMA UCMA TGFBR1 TGFBR1 DAB2 DAB2 MSX1 MSX1 RASL11B RASL11B VWC2 VWC2 MYOCD MYOCD BMP8B BMP8B HJV HJV KIAA1324L KIAA1324L PPM1A PPM1A CER1 CER1 DLX1 DLX1 NUP93 NUP93 BMP4 BMP4 HES1 HES1 GDF7 GDF7 STRAP STRAP HOXA13 HOXA13 LOC111559734 LOC111559734 FSTL3 FSTL3 TOB1 TOB1 DACT2 DACT2 ZC3H3 ZC3H3 ENSFCAP00000054808 ENSFCAP00000054808 ENSFCAP00000055099 ENSFCAP00000055099 ENSFCAP00000055271 ENSFCAP00000055271 PRDM16 PRDM16 SOX11 SOX11 ZNF423 ZNF423 ACVR2B ACVR2B CHRDL2 CHRDL2 ENSFCAP00000057420 ENSFCAP00000057420 LOC105261327 LOC105261327 CA3H20orf27 CA3H20orf27 NREP NREP ENSFCAP00000058884 ENSFCAP00000058884 NUMA1 NUMA1 LATS2 LATS2 ENSFCAP00000061110 ENSFCAP00000061110 KCP KCP GLG1 GLG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101093938Uncharacterized protein. (512 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BMPERBMP binding endothelial regulator. (685 aa)
BCL9LBCL9 like. (1393 aa)
NODALNodal growth differentiation factor. (348 aa)
FBXL15F-box and leucine rich repeat protein 15. (378 aa)
ENGEndoglin. (654 aa)
NANOGNanog homeobox. (311 aa)
SNW1SNW domain containing 1. (570 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
INHBEInhibin subunit beta E. (349 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
IL17RDInterleukin 17 receptor D. (736 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
SNX25Sorting nexin 25. (997 aa)
EP300E1A binding protein p300. (2425 aa)
CRB2Crumbs cell polarity complex component 2. (1283 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LEMD2LEM domain containing 2. (566 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
UBE2OUBIQUITIN_CONJUGAT_2 domain-containing protein. (1292 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
LRP2LDL receptor related protein 2. (4646 aa)
CREBBPCREB binding protein. (2444 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (954 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
IL17FInterleukin 17F. (157 aa)
ZNF451Zinc finger protein 451. (1063 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
NOTCH2Notch receptor 2. (2493 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
GDF15Growth differentiation factor 15. (307 aa)
GDF3Growth differentiation factor 3. (365 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
VASNVasorin. (692 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (602 aa)
THBS1Thrombospondin 1. (1170 aa)
CILPCartilage intermediate layer protein. (1183 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
TGFBR3Transforming growth factor beta receptor 3. (828 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
SPRED1Sprouty related EVH1 domain containing 1. (443 aa)
TBX20T-box transcription factor 20. (480 aa)
SORL1Sortilin related receptor 1. (2211 aa)
GIPC1GIPC PDZ domain containing family member 1. (447 aa)
SPRY1Sprouty RTK signaling antagonist 1. (362 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
TFAP2ETranscription factor AP-2 epsilon. (441 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CILP2Cartilage intermediate layer protein 2. (1157 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CDH5-2Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
HTRA3HtrA serine peptidase 3. (453 aa)
FBN1Fibrillin 1. (2871 aa)
ILKIntegrin linked kinase. (451 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
LEMD3LEM domain containing 3. (915 aa)
FERMT1Fermitin family member 1. (628 aa)
GDF11Growth differentiation factor 11. (404 aa)
LOC101084379Homeobox domain-containing protein. (290 aa)
ASPNAsporin. (372 aa)
CCN1Cellular communication network factor 1. (382 aa)
UBL3Ubiquitin-like protein. (117 aa)
ING2Inhibitor of growth protein. (280 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
EMILIN1Elastin microfibril interfacer 1. (1025 aa)
NOTCH1Notch receptor 1. (2543 aa)
SKISKI proto-oncogene. (730 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (573 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SDCBPSyndecan binding protein. (298 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (216 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
CD109CD109 molecule. (1446 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF6TGF_BETA_2 domain-containing protein. (462 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
GDF10Growth differentiation factor 10. (503 aa)
HIPK2Homeodomain interacting protein kinase 2. (1222 aa)
SULF1Sulfatase 1. (1116 aa)
INHBCInhibin subunit beta C. (353 aa)
SPARTSpartin. (672 aa)
SIRT1Sirtuin 1. (745 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (232 aa)
AXIN1Axin 1. (867 aa)
ONECUT2One cut domain family member. (504 aa)
CHST11Carbohydrate sulfotransferase. (395 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
RNF111Ring finger protein 111. (1002 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GIPC2GIPC PDZ domain containing family member 2. (313 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
RNF165Ring finger protein 165. (683 aa)
LOC101097198Uncharacterized protein. (1280 aa)
NKX2-1NK2 homeobox 1. (399 aa)
ENSFCAP00000033708RRM domain-containing protein. (202 aa)
NPNTNephronectin. (612 aa)
FSTFollistatin. (423 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
EID2EP300 interacting inhibitor of differentiation 2. (195 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
GDF5Growth differentiation factor 5. (499 aa)
NEO1Neogenin 1. (1480 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
NBL1NBL1, DAN family BMP antagonist. (176 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (665 aa)
SKILSKI like proto-oncogene. (686 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (833 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ZNF703Zinc finger protein 703. (592 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
TMPRSS6Transmembrane serine protease 6. (882 aa)
FSTL1Follistatin like 1. (328 aa)
INHBBInhibin subunit beta B. (407 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (346 aa)
BMP8ATGF_BETA_2 domain-containing protein. (402 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa)
TGFBR3LZP domain-containing protein. (485 aa)
CHRDL1Chordin like 1. (602 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1717 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (331 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FLCNUncharacterized protein. (579 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (549 aa)
ADAMTSL2ADAMTS like 2. (955 aa)
SKOR1SKI family transcriptional corepressor 1. (963 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
RBPMSRNA binding protein, mRNA processing factor. (411 aa)
SKOR2SKI family transcriptional corepressor 2. (1010 aa)
DAND5DAN domain BMP antagonist family member 5. (190 aa)
SOSTSclerostin. (212 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (187 aa)
CDH5Uncharacterized protein. (402 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (197 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
DAB2DAB adaptor protein 2. (769 aa)
MSX1Msh homeobox 1. (303 aa)
RASL11BRAS like family 11 member B. (248 aa)
VWC2Von Willebrand factor C domain containing 2. (333 aa)
MYOCDMyocardin. (962 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
KIAA1324LKIAA1324 like. (1029 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (486 aa)
CER1Cerberus 1, DAN family BMP antagonist. (270 aa)
DLX1Distal-less homeobox 1. (255 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (827 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GDF7Growth differentiation factor 7. (455 aa)
STRAPWD_REPEATS_REGION domain-containing protein. (350 aa)
HOXA13Homeobox A13. (389 aa)
LOC111559734Bone morphogenetic protein 7. (426 aa)
FSTL3Follistatin like 3. (364 aa)
TOB1Transducer of ERBB2, 1. (345 aa)
DACT2Dishevelled binding antagonist of beta catenin 2. (709 aa)
ZC3H3Zinc finger CCCH-type containing 3. (1016 aa)
ENSFCAP00000054808Uncharacterized protein. (786 aa)
ENSFCAP00000055099Uncharacterized protein. (115 aa)
ENSFCAP00000055271PID domain-containing protein. (114 aa)
PRDM16PR/SET domain 16. (1305 aa)
SOX11Transcription factor SOX. (412 aa)
ZNF423Zinc finger protein 423. (1318 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
CHRDL2Chordin like 2. (440 aa)
ENSFCAP00000057420Uncharacterized protein. (443 aa)
LOC105261327Left-right determination factor. (367 aa)
CA3H20orf27Chromosome A3 C20orf27 homolog. (197 aa)
NREPNeuronal regeneration related protein. (107 aa)
ENSFCAP00000058884Protein kinase domain-containing protein. (375 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2135 aa)
LATS2Non-specific serine/threonine protein kinase. (1095 aa)
ENSFCAP00000061110TGF_BETA_2 domain-containing protein. (362 aa)
KCPKielin cysteine rich BMP regulator. (1210 aa)
GLG1Golgi glycoprotein 1. (1250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (38%) [HD]