STRINGSTRING
SFRP1 SFRP1 FASLG FASLG CASP10 CASP10 FGF10 FGF10 IL7 IL7 TGFB2 TGFB2 RAF1 RAF1 DEDD2 DEDD2 CASP2 CASP2 TLR3 TLR3 DAB2IP DAB2IP FAS FAS PABPN1 PABPN1 MCL1 MCL1 FOXO3 FOXO3 GSK3A GSK3A ACVR1B ACVR1B DEDD DEDD STK4 STK4 DDX3X DDX3X BAG3 BAG3 MLLT11 MLLT11 ITPRIPL2 ITPRIPL2 SORT1 SORT1 ERBB3 ERBB3 RIPK1 RIPK1 NDUFA13 NDUFA13 COL2A1 COL2A1 IL2 IL2 BCL2A1 BCL2A1 WWOX WWOX P2RX7 P2RX7 IL12A IL12A PIK3R1 PIK3R1 RB1CC1 RB1CC1 DELE1 DELE1 IFNG IFNG IL1A IL1A PARP2 PARP2 PDIA3 PDIA3 TGFB1 TGFB1 DAPK1 DAPK1 SIVA1 SIVA1 CTTN CTTN BCL2 BCL2 EYA1 EYA1 BAX BAX KRT18 KRT18 PDPK1 PDPK1 IL4 IL4 PML PML TNFRSF1B TNFRSF1B DAXX DAXX CD27 CD27 STK3 STK3 ENSFCAP00000059874 ENSFCAP00000059874 BAK1 BAK1 BCL2L1 BCL2L1 EYA2 EYA2 BOK BOK PTPRC PTPRC NF1 NF1 TNFSF12 TNFSF12 CASP8 CASP8 PIDD1 PIDD1 ITPRIP ITPRIP DDX47 DDX47 LOC105261012 LOC105261012 ITGAV ITGAV TNF TNF DAXX-2 DAXX-2 BCL2L11 BCL2L11 YAP1 YAP1 BAD BAD ENSFCAP00000046520 ENSFCAP00000046520 INHBA INHBA TRADD TRADD NGF NGF FADD FADD BCL2L2 BCL2L2 FGFR3 FGFR3 GSK3B GSK3B G0S2 G0S2 BCL2L10 BCL2L10 RNF41 RNF41 SKIL SKIL HIPK1 HIPK1 CASP8AP2 CASP8AP2 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP1Secreted frizzled related protein 1. (314 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (482 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
IL7Interleukin 7. (158 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
DEDD2Death effector domain containing 2. (327 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
FASUncharacterized protein. (314 aa)
PABPN1Poly(A) binding protein nuclear 1. (306 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
FOXO3Forkhead box O3. (672 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
DEDDDeath effector domain containing. (318 aa)
STK4Serine/threonine kinase 4. (487 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (90 aa)
ITPRIPL2ITPRIP like 2. (532 aa)
SORT1Sortilin. (877 aa)
ERBB3ERBB3. (1339 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
BCL2A1BCL2 related protein A1. (174 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
DELE1DAP3 binding cell death enhancer 1. (518 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
PARP2Poly [ADP-ribose] polymerase. (567 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DAPK1Death associated protein kinase 1. (1429 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
CTTNCortactin. (538 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
PMLPromyelocytic leukemia. (876 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
DAXXDeath domain associated protein. (748 aa)
CD27CD27 molecule. (296 aa)
STK3Serine/threonine kinase 3. (573 aa)
ENSFCAP00000059874IF rod domain-containing protein; Belongs to the intermediate filament family. (136 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
BCL2L1BCL2 like 1. (271 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (657 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
NF1Neurofibromin 1. (2856 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (319 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
PIDD1P53-induced death domain protein 1. (940 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (552 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (476 aa)
LOC105261012Uncharacterized protein. (427 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
DAXX-2Daxx domain-containing protein. (769 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
YAP1Yes associated protein 1. (498 aa)
BADBCL2 associated agonist of cell death. (273 aa)
ENSFCAP00000046520IF rod domain-containing protein; Belongs to the intermediate filament family. (148 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
BCL2L2BCL2 like 2. (193 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
G0S2G0/G1 switch 2. (102 aa)
BCL2L10Uncharacterized protein. (192 aa)
RNF41Ring finger protein 41. (317 aa)
SKILSKI like proto-oncogene. (686 aa)
HIPK1Homeodomain interacting protein kinase 1. (1289 aa)
CASP8AP2Caspase 8 associated protein 2. (1779 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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