STRINGSTRING
ATM ATM BAX BAX SNW1 SNW1 DDIT3 DDIT3 MYBBP1A MYBBP1A ITPR1 ITPR1 STK25 STK25 PML PML ERN1 ERN1 DDX5 DDX5 TNFRSF1B TNFRSF1B BAG6 BAG6 EP300 EP300 E2F1 E2F1 ELL3 ELL3 TNFRSF1A TNFRSF1A ATAD5 ATAD5 NOX1 NOX1 MSH6 MSH6 HTRA2 HTRA2 MAP3K5 MAP3K5 AIFM1 AIFM1 ATF4 ATF4 PDK2 PDK2 QRICH1 QRICH1 EPHA2 EPHA2 PIK3R1 PIK3R1 DYRK2 DYRK2 IVNS1ABP IVNS1ABP TP73 TP73 E2F2 E2F2 NUPR1 NUPR1 WWOX WWOX BCL2A1 BCL2A1 CHAC1 CHAC1 MSH2 MSH2 STK11 STK11 IKBKE IKBKE CLU CLU RRP8 RRP8 ZNF622 ZNF622 USP47 USP47 JMY JMY CASP9 CASP9 MLLT11 MLLT11 DDIT4 DDIT4 STK26 STK26 AEN AEN DDX3X DDX3X BRCA2 BRCA2 CDKN1A CDKN1A TOPORS TOPORS BCL3 BCL3 ATF2 ATF2 ERO1A ERO1A PDCD10 PDCD10 CDIP1 CDIP1 MCL1 MCL1 HIC1 HIC1 PABPN1 PABPN1 PDK1 PDK1 ERCC6 ERCC6 TMEM109 TMEM109 COA8 COA8 FHIT FHIT HIPK2 HIPK2 PHLDA3 PHLDA3 SIRT1 SIRT1 ERN2 ERN2 TP63 TP63 DAB2IP DAB2IP PDX1 PDX1 PPP1R13B PPP1R13B IFI6 IFI6 BDKRB2 BDKRB2 CASP3 CASP3 CASP2 CASP2 DIABLO DIABLO GSKIP GSKIP TRIB3 TRIB3 PRKDC PRKDC HIPK1 HIPK1 SKIL SKIL LGALS12 LGALS12 ZNF385B ZNF385B RAD9A RAD9A RETREG1 RETREG1 FLCN FLCN BCL2L10 BCL2L10 CYP1B1 CYP1B1 ATP2A1 ATP2A1 BCL2L2 BCL2L2 TP53 TP53 BBC3 BBC3 CHEK2 CHEK2 BAD BAD CEBPB CEBPB ATP2A3 ATP2A3 RNF186 RNF186 PMAIP1 PMAIP1 BCL2L11 BCL2L11 NFATC4 NFATC4 PYCARD PYCARD TNF TNF MELK MELK NBN NBN CASP6 CASP6 POLB POLB TP53BP2 TP53BP2 ENSFCAP00000057195 ENSFCAP00000057195 BOK BOK ENSFCAP00000058884 ENSFCAP00000058884 BCL2L1 BCL2L1 BAK1 BAK1 NOL3 NOL3 SFN SFN TMEM117 TMEM117 BNIP3 BNIP3 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
SNW1SNW domain containing 1. (570 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
MYBBP1AMYB binding protein 1a. (1468 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
STK25Serine/threonine kinase 25. (426 aa)
PMLPromyelocytic leukemia. (876 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
BAG6BCL2 associated athanogene 6. (1184 aa)
EP300E1A binding protein p300. (2425 aa)
E2F1E2F transcription factor 1. (436 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
NOX1NADPH oxidase 1. (564 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1359 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
ATF4Activating transcription factor 4. (352 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
QRICH1Glutamine rich 1. (779 aa)
EPHA2EPH receptor A2. (936 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
IVNS1ABPInfluenza virus NS1A binding protein. (642 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (749 aa)
E2F2E2F transcription factor 2. (442 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
BCL2A1BCL2 related protein A1. (174 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (509 aa)
ZNF622Zinc finger protein 622. (495 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (988 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (90 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
STK26Serine/threonine kinase 26. (416 aa)
AENApoptosis enhancing nuclease. (409 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1042 aa)
BCL3BCL3 transcription coactivator. (454 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
PDCD10Programmed cell death 10. (212 aa)
CDIP1Cell death inducing p53 target 1. (370 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
HIC1HIC ZBTB transcriptional repressor 1. (732 aa)
PABPN1Poly(A) binding protein nuclear 1. (306 aa)
PDK1Protein-serine/threonine kinase. (449 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
TMEM109Transmembrane protein 109. (239 aa)
COA8Cytochrome c oxidase assembly factor 8. (205 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
HIPK2Homeodomain interacting protein kinase 2. (1222 aa)
PHLDA3Pleckstrin homology like domain family A member 3. (125 aa)
SIRT1Sirtuin 1. (745 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (927 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
PPP1R13BProtein phosphatase 1 regulatory subunit 13B. (1092 aa)
IFI6Interferon alpha inducible protein 6. (149 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
DIABLOUncharacterized protein. (237 aa)
GSKIPGSK3B interacting protein. (139 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4108 aa)
HIPK1Homeodomain interacting protein kinase 1. (1289 aa)
SKILSKI like proto-oncogene. (686 aa)
LGALS12Galectin. (336 aa)
ZNF385BZinc finger protein 385B. (489 aa)
RAD9ARAD9 checkpoint clamp component A. (641 aa)
RETREG1Reticulophagy regulator 1. (490 aa)
FLCNUncharacterized protein. (579 aa)
BCL2L10Uncharacterized protein. (192 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
BCL2L2BCL2 like 2. (193 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
BBC3Uncharacterized protein. (193 aa)
CHEK2Checkpoint kinase 2. (569 aa)
BADBCL2 associated agonist of cell death. (273 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa)
RNF186Ring finger protein 186. (220 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
NFATC4Nuclear factor of activated T cells 4. (930 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
MELKNon-specific serine/threonine protein kinase. (671 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa)
CASP6Caspase 6; Belongs to the phospholipase A2 family. (431 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (428 aa)
TP53BP2Tumor protein p53 binding protein 2. (1211 aa)
ENSFCAP00000057195Uncharacterized protein. (34 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
ENSFCAP00000058884Protein kinase domain-containing protein. (375 aa)
BCL2L1BCL2 like 1. (271 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
NOL3Nucleolar protein 3. (218 aa)
SFNStratifin; Belongs to the 14-3-3 family. (252 aa)
TMEM117Transmembrane protein 117. (531 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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