STRINGSTRING
PARP9 PARP9 DTX3L DTX3L CLDN18 CLDN18 TRIM29 TRIM29 NF2 NF2 PINX1 PINX1 TGFB1 TGFB1 CARD10 CARD10 HDAC3 HDAC3 ZC3H12A ZC3H12A POLR1A POLR1A IFNG IFNG CDK5RAP3 CDK5RAP3 PIN1 PIN1 NVL NVL ATP13A2 ATP13A2 MEPCE MEPCE PIK3R1 PIK3R1 UBR5 UBR5 SIN3A SIN3A LMNA LMNA ZPR1 ZPR1 GLI3 GLI3 STK11 STK11 CDK1 CDK1 HCLS1 HCLS1 FERMT1 FERMT1 FBXO4 FBXO4 F2 F2 BAG3 BAG3 PARK7 PARK7 TESK1 TESK1 LOC101082108 LOC101082108 LATS1 LATS1 MCRS1 MCRS1 APOD APOD FERMT2 FERMT2 CD2AP CD2AP LARP7 LARP7 LZTS2 LZTS2 PRKD1 PRKD1 NMD3 NMD3 DMAP1 DMAP1 TARDBP TARDBP JUP JUP LEP LEP TFRC TFRC LIF LIF WWTR1 WWTR1 ENSFCAP00000036821 ENSFCAP00000036821 ECT2 ECT2 DCLK1 DCLK1 FLNA FLNA ENSFCAP00000040164 ENSFCAP00000040164 SRC SRC TPR TPR FLCN FLCN TMEM98 TMEM98 CHP2 CHP2 PKIG PKIG PIK3R2 PIK3R2 NGFR NGFR ENSFCAP00000044386 ENSFCAP00000044386 KAT7 KAT7 MFHAS1 MFHAS1 CABP1 CABP1 RASSF5 RASSF5 YAP1 YAP1 BMP4 BMP4 ILRUN ILRUN IPO5 IPO5 PGM1 PGM1 RBM22 RBM22 GLIS2 GLIS2 ENSFCAP00000054337 ENSFCAP00000054337 TRIM8 TRIM8 NF1 NF1 SESN2 SESN2 LIMK2 LIMK2 SMO SMO ENSFCAP00000060155 ENSFCAP00000060155 LATS2 LATS2 ENSFCAP00000060774 ENSFCAP00000060774 PTPN22 PTPN22 TRIM28 TRIM28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARP9Poly(ADP-ribose) polymerase family member 9. (828 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (738 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TRIM29Tripartite motif containing 29. (620 aa)
NF2Neurofibromin 2. (596 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CARD10Caspase recruitment domain family member 10. (987 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1718 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (504 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
NVLNuclear VCP like. (868 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1161 aa)
MEPCEMethylphosphate capping enzyme. (689 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
ZPR1ZPR1 zinc finger. (459 aa)
GLI3GLI family zinc finger 3. (1578 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (494 aa)
FERMT1Fermitin family member 1. (628 aa)
FBXO4F-box protein 4. (387 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
LOC101082108Ig-like domain-containing protein. (386 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
MCRS1Microspherule protein 1. (541 aa)
APODApolipoprotein D. (189 aa)
FERMT2Fermitin family member 2. (706 aa)
CD2APCD2 associated protein. (639 aa)
LARP7La ribonucleoprotein domain family member 7. (582 aa)
LZTS2Leucine zipper tumor suppressor 2. (645 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (532 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (663 aa)
TARDBPTAR DNA binding protein. (414 aa)
JUPUncharacterized protein. (744 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ENSFCAP00000036821TDP43_N domain-containing protein. (82 aa)
ECT2Epithelial cell transforming 2. (914 aa)
DCLK1Doublecortin like kinase 1. (741 aa)
FLNAFilamin A. (2808 aa)
ENSFCAP00000040164TDP43_N domain-containing protein. (85 aa)
SRCTyrosine-protein kinase. (678 aa)
TPRTranslocated promoter region, nuclear basket protein. (2498 aa)
FLCNUncharacterized protein. (579 aa)
TMEM98Transmembrane protein 98. (226 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
PKIGcAMP-dependent protein kinase inhibitor gamma. (123 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
NGFRNerve growth factor receptor. (421 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1157 aa)
CABP1Calcium binding protein 1. (429 aa)
RASSF5Ras association domain family member 5. (425 aa)
YAP1Yes associated protein 1. (498 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (291 aa)
IPO5Importin 5. (1176 aa)
PGM1EF-hand calcium binding domain 7. (1049 aa)
RBM22RNA binding motif protein 22. (428 aa)
GLIS2GLIS family zinc finger 2. (622 aa)
ENSFCAP00000054337TDP43_N domain-containing protein. (90 aa)
TRIM8Tripartite motif containing 8. (551 aa)
NF1Neurofibromin 1. (2856 aa)
SESN2Sestrin 2. (516 aa)
LIMK2LIM domain kinase 2. (711 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
ENSFCAP00000060155TDP43_N domain-containing protein. (130 aa)
LATS2Non-specific serine/threonine protein kinase. (1095 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (801 aa)
TRIM28Tripartite motif containing 28. (821 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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