Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | ATM | ENSFCAP00000004739 | ENSFCAP00000025928 | Tyrosine-protein kinase. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.898 |
| ABL1 | CDK5 | ENSFCAP00000004739 | ENSFCAP00000021141 | Tyrosine-protein kinase. | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | 0.413 |
| ABL1 | FBXW7 | ENSFCAP00000004739 | ENSFCAP00000000575 | Tyrosine-protein kinase. | F-box and WD repeat domain containing 7. | 0.448 |
| ABL1 | TP53 | ENSFCAP00000004739 | ENSFCAP00000045749 | Tyrosine-protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.543 |
| ATF4 | DDIT3 | ENSFCAP00000008612 | ENSFCAP00000001926 | Activating transcription factor 4. | DNA damage inducible transcript 3. | 0.991 |
| ATF4 | DDIT4 | ENSFCAP00000008612 | ENSFCAP00000018731 | Activating transcription factor 4. | DNA damage inducible transcript 4. | 0.407 |
| ATF4 | EIF2S1 | ENSFCAP00000008612 | ENSFCAP00000019535 | Activating transcription factor 4. | Eukaryotic translation initiation factor 2 subunit alpha. | 0.966 |
| ATF4 | GSK3B | ENSFCAP00000008612 | ENSFCAP00000043679 | Activating transcription factor 4. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.910 |
| ATM | ABL1 | ENSFCAP00000025928 | ENSFCAP00000004739 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Tyrosine-protein kinase. | 0.898 |
| ATM | CASP9 | ENSFCAP00000025928 | ENSFCAP00000018153 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Caspase 9; Belongs to the peptidase C14A family. | 0.441 |
| ATM | FBXW7 | ENSFCAP00000025928 | ENSFCAP00000000575 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | F-box and WD repeat domain containing 7. | 0.426 |
| ATM | GSK3B | ENSFCAP00000025928 | ENSFCAP00000043679 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.416 |
| ATM | MCL1 | ENSFCAP00000025928 | ENSFCAP00000023698 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). | 0.412 |
| ATM | NF1 | ENSFCAP00000025928 | ENSFCAP00000055600 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Neurofibromin 1. | 0.495 |
| ATM | TP53 | ENSFCAP00000025928 | ENSFCAP00000045749 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.991 |
| BACE1 | CDK5 | ENSFCAP00000000163 | ENSFCAP00000021141 | Beta-secretase 1; Belongs to the peptidase A1 family. | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | 0.653 |
| BACE1 | GSK3B | ENSFCAP00000000163 | ENSFCAP00000043679 | Beta-secretase 1; Belongs to the peptidase A1 family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.519 |
| BACE1 | PRNP | ENSFCAP00000000163 | ENSFCAP00000030786 | Beta-secretase 1; Belongs to the peptidase A1 family. | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | 0.548 |
| BAD | BAX | ENSFCAP00000047559 | ENSFCAP00000000237 | BCL2 associated agonist of cell death. | BCL2 associated X, apoptosis regulator. | 0.840 |
| BAD | BCL2L11 | ENSFCAP00000047559 | ENSFCAP00000049779 | BCL2 associated agonist of cell death. | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. | 0.888 |
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