STRINGSTRING
APP APP CDC23 CDC23 UBE2C UBE2C KMT2E KMT2E RRM2 RRM2 CENPJ CENPJ RRM1 RRM1 HSPA2 HSPA2 CPSF3 CPSF3 CDC25A CDC25A MTA3 MTA3 MAD2L1BP MAD2L1BP RCC2 RCC2 MEPCE MEPCE SIN3A SIN3A STIL STIL ANAPC5 ANAPC5 ADAMTS1 ADAMTS1 ANKRD17 ANKRD17 CUL4A CUL4A CDC16 CDC16 CDK1 CDK1 RAB11B RAB11B KLHL18 KLHL18 PLRG1 PLRG1 CDK4 CDK4 VPS4B VPS4B DDX3X DDX3X ANAPC7 ANAPC7 CDC25C CDC25C RAD51C RAD51C PHB2 PHB2 RRM2B RRM2B SASS6 SASS6 CDC7 CDC7 CDCA5 CDCA5 AFMID AFMID RB1 RB1 MDM2 MDM2 CUL4B CUL4B ENSFCAP00000026963 ENSFCAP00000026963 ENSFCAP00000030965 ENSFCAP00000030965 FGF10 FGF10 BIRC5 BIRC5 CCND3 CCND3 RAD51B RAD51B EGFR EGFR RPTOR RPTOR WNT10B WNT10B CCND2 CCND2 CUL3 CUL3 DTL DTL STOX1 STOX1 MBLAC1 MBLAC1 TFDP1 TFDP1 MECP2 MECP2 CCND1 CCND1 CDC27 CDC27 ENSFCAP00000053720 ENSFCAP00000053720 MTBP MTBP LSM11 LSM11 CDT1 CDT1 NEUROG1 NEUROG1 LSM10 LSM10 NSMCE2 NSMCE2 RAB11A RAB11A AIF1 AIF1 ENSFCAP00000060774 ENSFCAP00000060774 ANXA1 ANXA1 EIF4EBP3 EIF4EBP3 CDC25B CDC25B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
CDC23Cell division cycle 23. (547 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (393 aa)
CENPJCentromere protein J. (1354 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (684 aa)
CDC25ACell division cycle 25A. (524 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
MAD2L1BPMAD2L1 binding protein. (274 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
MEPCEMethylphosphate capping enzyme. (689 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
STILSTIL centriolar assembly protein. (1302 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
ANKRD17Ankyrin repeat domain 17. (2608 aa)
CUL4ACullin 4A; Belongs to the cullin family. (761 aa)
CDC16Cell division cycle 16. (620 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
KLHL18Kelch like family member 18. (574 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
CDC25CCell division cycle 25C. (477 aa)
RAD51CRAD51 paralog C. (362 aa)
PHB2Prohibitin. (299 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (438 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
CDC7Cell division cycle 7. (574 aa)
CDCA5Cell division cycle associated 5. (252 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
RB1RB transcriptional corepressor 1. (930 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
CUL4BCullin 4B; Belongs to the cullin family. (911 aa)
ENSFCAP00000026963Uncharacterized protein. (73 aa)
ENSFCAP00000030965Protein kinase domain-containing protein. (104 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
RAD51BRAD51 paralog B. (350 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
STOX1Storkhead box 1. (878 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (337 aa)
TFDP1Transcription factor. (423 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
CDC27Cell division cycle 27. (839 aa)
ENSFCAP00000053720UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (114 aa)
MTBPMDM2 binding protein. (911 aa)
LSM11LSM11, U7 small nuclear RNA associated. (399 aa)
CDT1Chromatin licensing and DNA replication factor 1. (641 aa)
NEUROG1Neurogenin 1. (243 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (306 aa)
RAB11ARAB11A, member RAS oncogene family. (217 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
ANXA1Annexin. (407 aa)
EIF4EBP3ANK_REP_REGION domain-containing protein. (2635 aa)
CDC25BCell division cycle 25B. (578 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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