STRINGSTRING
PINX1 PINX1 MIIP MIIP APP APP CTC1 CTC1 ORC1 ORC1 INTS3 INTS3 NEK10 NEK10 BABAM2 BABAM2 CCNQ CCNQ MFSD11 MFSD11 BLM BLM ATAD5 ATAD5 RRM1 RRM1 HSPA2 HSPA2 PAXIP1 PAXIP1 CDC25A CDC25A MTA3 MTA3 CDK5RAP3 CDK5RAP3 RCC2 RCC2 NOP53 NOP53 SIN3A SIN3A NABP2 NABP2 NAE1 NAE1 PLK1 PLK1 TICRR TICRR RAD21 RAD21 MACROH2A1 MACROH2A1 CDK1 CDK1 CHEK1 CHEK1 RAB11B RAB11B ABRAXAS1 ABRAXAS1 USP47 USP47 CDK4 CDK4 VPS4B VPS4B UIMC1 UIMC1 KIF14 KIF14 CDKN1A CDKN1A TAOK3 TAOK3 CDC25C CDC25C NABP1 NABP1 RAD51C RAD51C RRM2B RRM2B MRE11 MRE11 CDC7 CDC7 CDC6 CDC6 TRIM60 TRIM60 FHL1 FHL1 CHMP4C CHMP4C LOC101098376 LOC101098376 DYRK3 DYRK3 ATM ATM CLSPN CLSPN ING4 ING4 LOC101098728 LOC101098728 ENSFCAP00000030965 ENSFCAP00000030965 FOXO4 FOXO4 CDK2 CDK2 ZFYVE19 ZFYVE19 CCNB3 CCNB3 INIP INIP BRCC3 BRCC3 BABAM1 BABAM1 RAD51B RAD51B TRIM75P TRIM75P WNT10B WNT10B FOXN3 FOXN3 C10orf90 C10orf90 DTL DTL STOX1 STOX1 TP53 TP53 SYF2 SYF2 GPR132 GPR132 HUS1 HUS1 ATF5 ATF5 MECP2 MECP2 FZR1 FZR1 MRNIP MRNIP CCND1 CCND1 CENPF CENPF VPS4A VPS4A NBN NBN TRIM39 TRIM39 CHFR CHFR AURKB AURKB ENSFCAP00000052534 ENSFCAP00000052534 ENSFCAP00000054710 ENSFCAP00000054710 ENSFCAP00000055731 ENSFCAP00000055731 RAD17 RAD17 AVEN AVEN DONSON DONSON ENSFCAP00000057489 ENSFCAP00000057489 RINT1 RINT1 RAB11A RAB11A ENSFCAP00000059078 ENSFCAP00000059078 ENSFCAP00000060774 ENSFCAP00000060774 ENSFCAP00000061058 ENSFCAP00000061058 TOPBP1 TOPBP1 CDC25B CDC25B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
MIIPMigration and invasion inhibitory protein. (460 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
CTC1CST telomere replication complex component 1. (1218 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (851 aa)
INTS3Integrator complex subunit 3. (1012 aa)
NEK10NIMA related kinase 10. (1173 aa)
BABAM2BRISC and BRCA1 A complex member 2. (386 aa)
CCNQCyclin Q; Belongs to the cyclin family. (376 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
BLMBLM RecQ like helicase. (1428 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
PAXIP1PAX interacting protein 1. (1016 aa)
CDC25ACell division cycle 25A. (524 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (504 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
NOP53NOP53 ribosome biogenesis factor. (485 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (589 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1884 aa)
RAD21RAD21 cohesin complex component. (631 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
UIMC1Ubiquitin interaction motif containing 1. (722 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1575 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
TAOK3TAO kinase 3. (914 aa)
CDC25CCell division cycle 25C. (477 aa)
NABP1Nucleic acid binding protein 1. (219 aa)
RAD51CRAD51 paralog C. (362 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (438 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa)
CDC7Cell division cycle 7. (574 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
TRIM60Tripartite motif containing 60. (471 aa)
FHL1Four and a half LIM domains 1. (366 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
LOC101098376Uncharacterized protein. (473 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
CLSPNClaspin. (1327 aa)
ING4Inhibitor of growth protein. (249 aa)
LOC101098728Uncharacterized protein. (289 aa)
ENSFCAP00000030965Protein kinase domain-containing protein. (104 aa)
FOXO4Forkhead box O4. (515 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (400 aa)
CCNB3Uncharacterized protein; Belongs to the cyclin family. (285 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (316 aa)
BABAM1Uncharacterized protein. (334 aa)
RAD51BRAD51 paralog B. (350 aa)
TRIM75PTripartite motif containing 75, pseudogene. (469 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
FOXN3Forkhead box N3. (488 aa)
C10orf90Chromosome 10 open reading frame 90. (655 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
STOX1Storkhead box 1. (878 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
SYF2Uncharacterized protein. (246 aa)
GPR132G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATF5Activating transcription factor 5. (280 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
MRNIPMRN complex interacting protein. (348 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
CENPFCentromere protein F. (3094 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (448 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa)
TRIM39Tripartite motif containing 39. (517 aa)
CHFRCheckpoint with forkhead and ring finger domains. (833 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (408 aa)
ENSFCAP00000052534Reverse transcriptase domain-containing protein. (665 aa)
ENSFCAP00000054710Reverse transcriptase domain-containing protein. (817 aa)
ENSFCAP00000055731Reverse transcriptase domain-containing protein. (713 aa)
RAD17RAD17 checkpoint clamp loader component. (726 aa)
AVENApoptosis and caspase activation inhibitor. (356 aa)
DONSONDownstream neighbor of SON. (612 aa)
ENSFCAP00000057489Uncharacterized protein. (192 aa)
RINT1RAD50 interactor 1. (794 aa)
RAB11ARAB11A, member RAS oncogene family. (217 aa)
ENSFCAP00000059078Reverse transcriptase domain-containing protein. (240 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
ENSFCAP00000061058Reverse transcriptase domain-containing protein. (767 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1551 aa)
CDC25BCell division cycle 25B. (578 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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