STRINGSTRING
STAT3 STAT3 HIF1A HIF1A SMAD1 SMAD1 NR1H2 NR1H2 SMAD6 SMAD6 IL10 IL10 SREBF2 SREBF2 PRL PRL PDGFB PDGFB GNL3 GNL3 MRTFB MRTFB SRF SRF JUN JUN FOXO3 FOXO3 KLF5 KLF5 BMPR1A BMPR1A M3XGE2_FELCA M3XGE2_FELCA FOSL1 FOSL1 EGR1 EGR1 BMP2 BMP2 SMAD4 SMAD4 TGFB2 TGFB2 SMAD3 SMAD3 WT1 WT1 GATA3 GATA3 NGFR NGFR MYC MYC TP53 TP53 RELA RELA MYOCD MYOCD TNF TNF BMP4 BMP4 ATOH8 ATOH8 ETS1 ETS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (770 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1236 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
GNL3G protein nucleolar 3. (549 aa)
MRTFBMyocardin related transcription factor B. (1118 aa)
SRFSerum response factor. (512 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
FOXO3Forkhead box O3. (672 aa)
KLF5Kruppel like factor 5. (457 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
M3XGE2_FELCAUncharacterized protein. (87 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (273 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
WT1WT1 transcription factor. (523 aa)
GATA3GATA binding protein 3. (444 aa)
NGFRNerve growth factor receptor. (421 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
MYOCDMyocardin. (962 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ATOH8Atonal bHLH transcription factor 8. (355 aa)
ETS1ETS proto-oncogene 1, transcription factor. (503 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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