STRINGSTRING
WDR63 WDR63 LMOD1 LMOD1 SPTBN4 SPTBN4 TMOD1 TMOD1 PFDN1 PFDN1 CAMSAP1 CAMSAP1 VILL VILL VIL1 VIL1 KATNB1 KATNB1 TREM2 TREM2 PICK1 PICK1 SPTB SPTB CAPG CAPG CORO1B CORO1B TTBK2 TTBK2 SWAP70 SWAP70 PRKCD PRKCD PFN4 PFN4 MID1IP1 MID1IP1 CAMSAP2 CAMSAP2 PPFIA1 PPFIA1 SCIN SCIN TMOD4 TMOD4 DEF6 DEF6 HIP1R HIP1R CAPZA3 CAPZA3 SPTBN2 SPTBN2 MAPRE1 MAPRE1 WASF2 WASF2 MKKS MKKS LMOD3 LMOD3 CLUL1 CLUL1 LIMA1 LIMA1 CKAP2 CKAP2 PIK3R1 PIK3R1 TM6SF1 TM6SF1 PFDN2 PFDN2 CAPZA1 CAPZA1 PLEKHH2 PLEKHH2 TBCD TBCD CLU CLU AVIL AVIL RHPN2 RHPN2 CDH5-2 CDH5-2 ARHGAP28 ARHGAP28 ARFGEF1 ARFGEF1 WAS WAS CGNL1 CGNL1 PAK2 PAK2 CORO2A CORO2A CRYAB CRYAB VBP1 VBP1 MYADM MYADM TWF2 TWF2 EMILIN1 EMILIN1 SSH1 SSH1 KANK4 KANK4 SPTBN5 SPTBN5 CAPZA2 CAPZA2 CIB1 CIB1 ADD2 ADD2 ADD1 ADD1 ENSFCAP00000027627 ENSFCAP00000027627 ENSFCAP00000028692 ENSFCAP00000028692 ENSFCAP00000029374 ENSFCAP00000029374 SPTAN1 SPTAN1 TMEFF2 TMEFF2 CAV3 CAV3 SMAD4 SMAD4 SPTBN1 SPTBN1 ATXN7L1 ATXN7L1 MYOC MYOC TWF1 TWF1 RDX RDX BBS4 BBS4 ARHGEF2 ARHGEF2 STMN2 STMN2 ENSFCAP00000034093 ENSFCAP00000034093 PIK3CA PIK3CA CORO1A CORO1A HDGFL3 HDGFL3 PHLDB2 PHLDB2 APC APC EML2 EML2 GAS2L2 GAS2L2 FLII FLII SLIT2 SLIT2 SPTA1 SPTA1 FAM49B FAM49B APC2 APC2 LOC102901344 LOC102901344 GMFB GMFB ATXN7 ATXN7 CAPZB CAPZB DYRK1A DYRK1A PFN2 PFN2 EPS8 EPS8 PRKN PRKN F11R F11R ENSFCAP00000044477 ENSFCAP00000044477 ENSFCAP00000044600 ENSFCAP00000044600 HDAC6 HDAC6 ENSFCAP00000045292 ENSFCAP00000045292 SSH2 SSH2 CDH5 CDH5 ADD3 ADD3 ENSFCAP00000046486 ENSFCAP00000046486 PFDN5 PFDN5 ARHGEF18 ARHGEF18 DMTN DMTN NAV3 NAV3 ARAP1 ARAP1 CAMSAP3 CAMSAP3 CSN1S1 CSN1S1 ASB15 ASB15 ARHGAP6 ARHGAP6 LDLR LDLR TMSB10 TMSB10 TMOD2 TMOD2 CLIP3 CLIP3 BMERB1 BMERB1 GSN GSN CHADL CHADL SSH3 SSH3 GMFG GMFG RHPN1 RHPN1 ENSFCAP00000057249 ENSFCAP00000057249 ATXN7L2 ATXN7L2 ENSFCAP00000059017 ENSFCAP00000059017 TACC3 TACC3 MAP6D1 MAP6D1 SVIL SVIL KANK3 KANK3 INPP5K INPP5K KANK1 KANK1 MET MET CORO2B CORO2B SPEF1 SPEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR63WD repeat domain 63. (908 aa)
LMOD1Leiomodin 1. (579 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2568 aa)
TMOD1Tropomodulin 1. (346 aa)
PFDN1Prefoldin subunit 1. (122 aa)
CAMSAP1Calmodulin regulated spectrin associated protein 1. (1507 aa)
VILLVillin like. (855 aa)
VIL1Villin 1. (827 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (655 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2326 aa)
CAPGCapping actin protein, gelsolin like. (388 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
TTBK2Tau tubulin kinase 2. (1252 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
CAMSAP2Calmodulin regulated spectrin associated protein family member 2. (1490 aa)
PPFIA1PTPRF interacting protein alpha 1. (1069 aa)
SCINScinderin. (715 aa)
TMOD4Tropomodulin 4. (345 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2418 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (268 aa)
WASF2WASP family member 2. (498 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
LMOD3Leiomodin 3. (577 aa)
CLUL1Clusterin; Belongs to the clusterin family. (468 aa)
LIMA1LIM domain and actin binding 1. (780 aa)
CKAP2CKAP2_C domain-containing protein. (682 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TM6SF1Transmembrane 6 superfamily member 1. (370 aa)
PFDN2Prefoldin subunit 2. (154 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1492 aa)
TBCDTubulin folding cofactor D. (1189 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
AVILAdvillin. (816 aa)
RHPN2Rhophilin Rho GTPase binding protein 2. (686 aa)
CDH5-2Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
ARHGAP28Rho GTPase activating protein 28. (729 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
WASWASP actin nucleation promoting factor. (501 aa)
CGNL1Cingulin like 1. (1293 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (515 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
VBP1Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (197 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
EMILIN1Elastin microfibril interfacer 1. (1025 aa)
SSH1Slingshot protein phosphatase 1. (1051 aa)
KANK4KN motif and ankyrin repeat domains 4. (1013 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3515 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (394 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ADD2Adducin 2. (723 aa)
ADD1Adducin 1. (761 aa)
ENSFCAP00000027627CKAP2_C domain-containing protein. (640 aa)
ENSFCAP00000028692Uncharacterized protein. (98 aa)
ENSFCAP00000029374F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (162 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2725 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (394 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
ATXN7L1Ataxin 7 like 1. (959 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (498 aa)
TWF1Twinfilin actin binding protein 1. (357 aa)
RDXRadixin. (604 aa)
BBS4Bardet-Biedl syndrome 4. (525 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1181 aa)
STMN2Stathmin 2. (202 aa)
ENSFCAP00000034093Uncharacterized protein; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (88 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (655 aa)
HDGFL3HDGF like 3. (203 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1247 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
EML2EMAP like 2. (849 aa)
GAS2L2Growth arrest specific 2 like 2. (879 aa)
FLIIFLII actin remodeling protein. (1276 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
FAM49BFamily with sequence similarity 49 member B. (378 aa)
APC2APC regulator of WNT signaling pathway 2. (2289 aa)
LOC102901344Uncharacterized protein. (226 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (143 aa)
ATXN7Ataxin 7. (946 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
F11RJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...] (378 aa)
ENSFCAP00000044477Uncharacterized protein. (43 aa)
ENSFCAP00000044600Uncharacterized protein. (66 aa)
HDAC6Histone deacetylase 6. (1178 aa)
ENSFCAP00000045292CH_2 domain-containing protein. (564 aa)
SSH2Slingshot protein phosphatase 2. (1435 aa)
CDH5Uncharacterized protein. (402 aa)
ADD3Adducin 3. (706 aa)
ENSFCAP00000046486Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
PFDN5Uncharacterized protein. (154 aa)
ARHGEF18Uncharacterized protein. (1357 aa)
DMTNDematin actin binding protein. (405 aa)
NAV3Neuron navigator 3. (2385 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1455 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1218 aa)
CSN1S1Casein alpha s1. (183 aa)
ASB15Ankyrin repeat and SOCS box containing 15. (597 aa)
ARHGAP6Rho GTPase activating protein 6. (455 aa)
LDLRLow density lipoprotein receptor. (866 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
TMOD2Tropomodulin 3. (440 aa)
CLIP3CAP-Gly domain containing linker protein 3. (571 aa)
BMERB1BMERB domain containing 1. (204 aa)
GSNGelsolin. (815 aa)
CHADLChondroadherin like. (891 aa)
SSH3Slingshot protein phosphatase 3. (663 aa)
GMFGGlia maturation factor gamma. (195 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (760 aa)
ENSFCAP00000057249Uncharacterized protein. (57 aa)
ATXN7L2Ataxin 7 like 2. (779 aa)
ENSFCAP00000059017Uncharacterized protein. (73 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (806 aa)
MAP6D1MAP6 domain containing 1. (254 aa)
SVILSupervillin. (2361 aa)
KANK3KN motif and ankyrin repeat domains 3. (862 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (525 aa)
KANK1KN motif and ankyrin repeat domains 1. (1366 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (501 aa)
SPEF1Sperm flagellar 1. (343 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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