STRINGSTRING
AMBRA1 AMBRA1 MTIF2 MTIF2 ATG9B ATG9B BECN1 BECN1 FBXL4 FBXL4 ATG2A ATG2A RETREG3 RETREG3 ATG9A ATG9A MTIF3 MTIF3 SNX30 SNX30 NEDD9 NEDD9 ATG2B ATG2B TEX264 TEX264 WDR45B WDR45B STING1 STING1 VCP VCP GBA GBA PINK1 PINK1 RETREG2 RETREG2 ULK1 ULK1 RB1CC1 RB1CC1 PLIN3 PLIN3 UFC1 UFC1 FBXO7 FBXO7 GABARAPL2 GABARAPL2 USP30 USP30 UFL1 UFL1 PHB2 PHB2 SPAST SPAST FUNDC2 FUNDC2 DDRGK1 DDRGK1 EIF2D-2 EIF2D-2 ZFAND1 ZFAND1 AURKA AURKA KIF5B KIF5B ENSFCAP00000033718 ENSFCAP00000033718 PRKAA2 PRKAA2 MCTS1 MCTS1 RRP7A RRP7A KIF9 KIF9 LOC101095070 LOC101095070 PRAF2 PRAF2 PELO PELO VRK1 VRK1 ATG7 ATG7 GFM2 GFM2 ARFIP2 ARFIP2 EIF2D EIF2D FIS1 FIS1 ATG12 ATG12 KAT5 KAT5 MAP1LC3C MAP1LC3C ENSFCAP00000041779 ENSFCAP00000041779 SPATA33 SPATA33 PRKN PRKN ENSFCAP00000044926 ENSFCAP00000044926 HDAC6 HDAC6 TP53 TP53 ATG3 ATG3 ATG5 ATG5 GABARAPL1 GABARAPL1 TIGAR TIGAR MAP1LC3B MAP1LC3B ATG14 ATG14 SNX7 SNX7 WIPI2 WIPI2 ATG4D ATG4D PLIN2 PLIN2 SPATA18 SPATA18 WIPI1 WIPI1 ATG4B ATG4B ENSFCAP00000060319 ENSFCAP00000060319 ENSFCAP00000060774 ENSFCAP00000060774 CDK1 CDK1 LOC101097564 LOC101097564 MAP1LC3A MAP1LC3A ENSFCAP00000031232 ENSFCAP00000031232 OGT OGT FUNDC1 FUNDC1 UBA5 UBA5 DYRK3 DYRK3 PRKAA1 PRKAA1 CISD2 CISD2 GABARAP GABARAP PNPLA2 PNPLA2 STX5 STX5 SQSTM1 SQSTM1 ATG13 ATG13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
MTIF2Mitochondrial translational initiation factor 2. (727 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
BECN1Beclin 1. (448 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
ATG2AAutophagy related 2A. (1928 aa)
RETREG3Reticulophagy regulator family member 3. (466 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (998 aa)
MTIF3Mitochondrial translational initiation factor 3. (298 aa)
SNX30Sorting nexin family member 30. (449 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
ATG2BAutophagy related 2B. (2114 aa)
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
WDR45BWD repeat domain 45B. (344 aa)
STING1Stimulator of interferon genes. (377 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (761 aa)
GBAGlucosylceramidase. (536 aa)
PINK1PTEN induced kinase 1. (581 aa)
RETREG2Reticulophagy regulator family member 2. (546 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
PLIN3Perilipin; Belongs to the perilipin family. (438 aa)
UFC1Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
FBXO7F-box protein 7. (444 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (519 aa)
UFL1UFM1 specific ligase 1. (792 aa)
PHB2Prohibitin. (299 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
FUNDC2FUN14 domain containing 2. (190 aa)
DDRGK1DDRGK domain containing 1. (340 aa)
EIF2D-2Pre-PUA domain-containing protein. (163 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (404 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
ENSFCAP00000033718ZnF_CDGSH domain-containing protein. (99 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MCTS1Malignant T-cell-amplified sequence. (182 aa)
RRP7ARibosomal RNA processing 7 homolog A. (355 aa)
KIF9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (804 aa)
LOC101095070Uncharacterized protein. (141 aa)
PRAF2WD repeat domain 45. (361 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (418 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa)
GFM2Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (780 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (374 aa)
EIF2DEukaryotic translation initiation factor 2D. (559 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
MAP1LC3CUncharacterized protein. (141 aa)
ENSFCAP00000041779Uncharacterized protein. (112 aa)
SPATA33Uncharacterized protein. (96 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
ENSFCAP00000044926Uncharacterized protein. (107 aa)
HDAC6Histone deacetylase 6. (1178 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
ATG3Autophagy-related protein 3. (333 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
GABARAPL1GABA type A receptor associated protein like 1. (151 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
MAP1LC3BUncharacterized protein. (309 aa)
ATG14Autophagy related 14. (510 aa)
SNX7Sorting nexin 7. (513 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (468 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (475 aa)
PLIN2Perilipin; Belongs to the perilipin family. (447 aa)
SPATA18Spermatogenesis associated 18. (540 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (470 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (578 aa)
ENSFCAP00000060319Uncharacterized protein. (108 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
LOC101097564Malignant T-cell-amplified sequence. (181 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
ENSFCAP00000031232Uncharacterized protein. (108 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
FUNDC1Uncharacterized protein. (155 aa)
UBA5Ubiquitin like modifier activating enzyme 5. (404 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
CISD2CDGSH iron sulfur domain 2. (135 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
PNPLA2Patatin like phospholipase domain containing 2. (486 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (355 aa)
SQSTM1Sequestosome 1. (443 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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