19 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	FBXW7	F-box and WD repeat domain containing 7. (749 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	PARL	Rhomboid domain-containing protein. (379 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4389 aa)
	HTT	Huntingtin. (3140 aa)
	CTTN	Cortactin. (538 aa)
	FBXO7	F-box protein 7. (444 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	M3WWT0_FELCA	Rhomboid domain-containing protein. (188 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
	VPS13C	Vacuolar protein sorting 13 homolog C. (3752 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	RNF41	Ring finger protein 41. (317 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (428 aa)
	TSPO	Uncharacterized protein. (257 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	PINK1	ENSFCAP00000012643	ENSFCAP00000000737	Autophagy and beclin 1 regulator 1.	PTEN induced kinase 1.	0.522
AMBRA1	PRKN	ENSFCAP00000012643	ENSFCAP00000043123	Autophagy and beclin 1 regulator 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.955
FBXO7	PINK1	ENSFCAP00000009092	ENSFCAP00000000737	F-box protein 7.	PTEN induced kinase 1.	0.783
FBXO7	PRKN	ENSFCAP00000009092	ENSFCAP00000043123	F-box protein 7.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.604
FBXO7	VPS13C	ENSFCAP00000009092	ENSFCAP00000024324	F-box protein 7.	Vacuolar protein sorting 13 homolog C.	0.623
FBXW7	PRKN	ENSFCAP00000000575	ENSFCAP00000043123	F-box and WD repeat domain containing 7.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.620
FBXW7	TP53	ENSFCAP00000000575	ENSFCAP00000045749	F-box and WD repeat domain containing 7.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.719
GSK3A	TP53	ENSFCAP00000022346	ENSFCAP00000045749	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.428
HIF1A	TP53	ENSFCAP00000003163	ENSFCAP00000045749	Hypoxia inducible factor 1 subunit alpha.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.849
HTT	PINK1	ENSFCAP00000004259	ENSFCAP00000000737	Huntingtin.	PTEN induced kinase 1.	0.426
HTT	PRKN	ENSFCAP00000004259	ENSFCAP00000043123	Huntingtin.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.597
HTT	TP53	ENSFCAP00000004259	ENSFCAP00000045749	Huntingtin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.513
M3WWT0_FELCA	PINK1	ENSFCAP00000018819	ENSFCAP00000000737	Rhomboid domain-containing protein.	PTEN induced kinase 1.	0.651
M3WWT0_FELCA	PRKN	ENSFCAP00000018819	ENSFCAP00000043123	Rhomboid domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.646
PARL	PINK1	ENSFCAP00000002872	ENSFCAP00000000737	Rhomboid domain-containing protein.	PTEN induced kinase 1.	0.651
PARL	PRKN	ENSFCAP00000002872	ENSFCAP00000043123	Rhomboid domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.646
PINK1	AMBRA1	ENSFCAP00000000737	ENSFCAP00000012643	PTEN induced kinase 1.	Autophagy and beclin 1 regulator 1.	0.522
PINK1	FBXO7	ENSFCAP00000000737	ENSFCAP00000009092	PTEN induced kinase 1.	F-box protein 7.	0.783
PINK1	HTT	ENSFCAP00000000737	ENSFCAP00000004259	PTEN induced kinase 1.	Huntingtin.	0.426
PINK1	M3WWT0_FELCA	ENSFCAP00000000737	ENSFCAP00000018819	PTEN induced kinase 1.	Rhomboid domain-containing protein.	0.651