(26 nodes) Positive regulation of signaling receptor activity network (Felis catus)

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	AREG	Amphiregulin. (323 aa)
	NCF1	Neutrophil cytosolic factor 1. (390 aa)
	RELN	Reelin. (3460 aa)
	HDAC6	Histone deacetylase 6. (1178 aa)
	TGFA	Transforming growth factor alpha. (192 aa)
	EPGN	Epithelial mitogen. (153 aa)
	HDAC2	Histone deacetylase 2. (602 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	BTC	Betacellulin. (194 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
	BUD31	BUD31 homolog. (144 aa)
	ADRA2C	Adrenoceptor alpha 2C. (476 aa)
	ADRA2B	Adrenoceptor alpha 2B. (444 aa)
	THAP11	THAP domain containing 11. (300 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (574 aa)
	EREG	Epiregulin. (169 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	HBEGF	Heparin binding EGF like growth factor. (305 aa)
	FBXW7	F-box and WD repeat domain containing 7. (749 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2B	ADRA2C	ENSFCAP00000020451	ENSFCAP00000021814	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2C.	0.455
ADRA2C	ADRA2B	ENSFCAP00000021814	ENSFCAP00000020451	Adrenoceptor alpha 2C.	Adrenoceptor alpha 2B.	0.455
ADRB2	EDN1	ENSFCAP00000007370	ENSFCAP00000013767	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.722
AREG	BTC	ENSFCAP00000000341	ENSFCAP00000033685	Amphiregulin.	Betacellulin.	0.899
AREG	EPGN	ENSFCAP00000000341	ENSFCAP00000040267	Amphiregulin.	Epithelial mitogen.	0.690
AREG	EREG	ENSFCAP00000000341	ENSFCAP00000018320	Amphiregulin.	Epiregulin.	0.940
AREG	HBEGF	ENSFCAP00000000341	ENSFCAP00000001182	Amphiregulin.	Heparin binding EGF like growth factor.	0.536
AREG	TGFA	ENSFCAP00000000341	ENSFCAP00000040793	Amphiregulin.	Transforming growth factor alpha.	0.778
BTC	AREG	ENSFCAP00000033685	ENSFCAP00000000341	Betacellulin.	Amphiregulin.	0.899
BTC	EPGN	ENSFCAP00000033685	ENSFCAP00000040267	Betacellulin.	Epithelial mitogen.	0.790
BTC	EREG	ENSFCAP00000033685	ENSFCAP00000018320	Betacellulin.	Epiregulin.	0.761
BTC	HBEGF	ENSFCAP00000033685	ENSFCAP00000001182	Betacellulin.	Heparin binding EGF like growth factor.	0.637
BTC	TGFA	ENSFCAP00000033685	ENSFCAP00000040793	Betacellulin.	Transforming growth factor alpha.	0.512
EDN1	ADRB2	ENSFCAP00000013767	ENSFCAP00000007370	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.722
EDN1	HIF1A	ENSFCAP00000013767	ENSFCAP00000003163	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Hypoxia inducible factor 1 subunit alpha.	0.538
EPGN	AREG	ENSFCAP00000040267	ENSFCAP00000000341	Epithelial mitogen.	Amphiregulin.	0.690
EPGN	BTC	ENSFCAP00000040267	ENSFCAP00000033685	Epithelial mitogen.	Betacellulin.	0.790
EPGN	EREG	ENSFCAP00000040267	ENSFCAP00000018320	Epithelial mitogen.	Epiregulin.	0.773
EPGN	HBEGF	ENSFCAP00000040267	ENSFCAP00000001182	Epithelial mitogen.	Heparin binding EGF like growth factor.	0.600
EPGN	TGFA	ENSFCAP00000040267	ENSFCAP00000040793	Epithelial mitogen.	Transforming growth factor alpha.	0.613