(22 nodes) Negative regulation of endothelial cell apoptotic process network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA3	GATA binding protein 3. (444 aa)
	CDH5-2	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
	SCG2	Secretogranin II. (680 aa)
	PAK4	Non-specific serine/threonine protein kinase. (592 aa)
	KRIT1	KRIT1 ankyrin repeat containing. (736 aa)
	TNFAIP3	TNF alpha induced protein 3. (804 aa)
	CDH5	Uncharacterized protein. (402 aa)
	ANGPTL4	Angiopoietin like 4. (414 aa)
	NDNF	Neuron derived neurotrophic factor. (568 aa)
	IL13	Interleukin 13. (144 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
	TEK	TEK receptor tyrosine kinase. (1125 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	GAS6	Growth arrest specific 6. (674 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
	RAMP2	Receptor activity modifying protein 2. (206 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (804 aa)
	FGB	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (473 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL4	TEK	ENSFCAP00000014114	ENSFCAP00000002604	Angiopoietin like 4.	TEK receptor tyrosine kinase.	0.559
BRAF	FGB	ENSFCAP00000011915	ENSFCAP00000012290	B-Raf proto-oncogene, serine/threonine kinase.	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...]	0.408
BRAF	MAPK7	ENSFCAP00000011915	ENSFCAP00000008198	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.575
CDH5	CDH5-2	ENSFCAP00000046015	ENSFCAP00000014138	Uncharacterized protein.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.899
CDH5	KDR	ENSFCAP00000046015	ENSFCAP00000008977	Uncharacterized protein.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.915
CDH5	KRIT1	ENSFCAP00000046015	ENSFCAP00000017884	Uncharacterized protein.	KRIT1 ankyrin repeat containing.	0.602
CDH5	TEK	ENSFCAP00000046015	ENSFCAP00000002604	Uncharacterized protein.	TEK receptor tyrosine kinase.	0.604
CDH5-2	CDH5	ENSFCAP00000014138	ENSFCAP00000046015	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.899
CDH5-2	KDR	ENSFCAP00000014138	ENSFCAP00000008977	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.592
CDH5-2	KRIT1	ENSFCAP00000014138	ENSFCAP00000017884	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	KRIT1 ankyrin repeat containing.	0.602
CDH5-2	TEK	ENSFCAP00000014138	ENSFCAP00000002604	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	TEK receptor tyrosine kinase.	0.604
FGB	BRAF	ENSFCAP00000012290	ENSFCAP00000011915	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...]	B-Raf proto-oncogene, serine/threonine kinase.	0.408
GATA3	IL10	ENSFCAP00000044199	ENSFCAP00000012535	GATA binding protein 3.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.672
GATA3	IL13	ENSFCAP00000044199	ENSFCAP00000035894	GATA binding protein 3.	Interleukin 13.	0.753
GATA3	IL4	ENSFCAP00000044199	ENSFCAP00000002290	GATA binding protein 3.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.778
IL10	GATA3	ENSFCAP00000012535	ENSFCAP00000044199	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	GATA binding protein 3.	0.672
IL10	IL13	ENSFCAP00000012535	ENSFCAP00000035894	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 13.	0.914
IL10	IL4	ENSFCAP00000012535	ENSFCAP00000002290	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.988
IL10	NFE2L2	ENSFCAP00000012535	ENSFCAP00000011270	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Nuclear factor, erythroid 2 like 2.	0.418
IL13	GATA3	ENSFCAP00000035894	ENSFCAP00000044199	Interleukin 13.	GATA binding protein 3.	0.753