25 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PINK1	PTEN induced kinase 1. (581 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (733 aa)
	HK2	Hexokinase 2. (917 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	TFAP2A	Transcription factor AP-2 alpha. (437 aa)
	BECN1	Beclin 1. (448 aa)
	SLC30A10	Solute carrier family 30 member 10. (483 aa)
	MMP3	Matrix metallopeptidase 3. (478 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (460 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1282 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (739 aa)
	COA8	Cytochrome c oxidase assembly factor 8. (205 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
	ENSFCAP00000044386	Uncharacterized protein. (156 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (428 aa)
	AATF	Apoptosis antagonizing transcription factor. (568 aa)
	PAGE4	PAGE family member 4. (105 aa)
	SIRT2	Sirtuin 2. (497 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (300 aa)
	PON3	Paraoxonase 3. (438 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	BECN1	ENSFCAP00000046882	ENSFCAP00000012183	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin 1.	0.954
ATG5	ENSFCAP00000044386	ENSFCAP00000046882	ENSFCAP00000044386	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.437
ATG5	HIF1A	ENSFCAP00000046882	ENSFCAP00000003163	Autophagy protein 5; Involved in autophagic vesicle formation.	Hypoxia inducible factor 1 subunit alpha.	0.459
ATG5	PINK1	ENSFCAP00000046882	ENSFCAP00000000737	Autophagy protein 5; Involved in autophagic vesicle formation.	PTEN induced kinase 1.	0.563
ATG5	PRKN	ENSFCAP00000046882	ENSFCAP00000043123	Autophagy protein 5; Involved in autophagic vesicle formation.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.549
ATG5	TP53	ENSFCAP00000046882	ENSFCAP00000045749	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.515
ATG5	VDAC1	ENSFCAP00000046882	ENSFCAP00000037323	Autophagy protein 5; Involved in autophagic vesicle formation.	Voltage dependent anion channel 1.	0.644
BECN1	ATG5	ENSFCAP00000012183	ENSFCAP00000046882	Beclin 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.954
BECN1	ENSFCAP00000044386	ENSFCAP00000012183	ENSFCAP00000044386	Beclin 1.	Uncharacterized protein.	0.455
BECN1	HIF1A	ENSFCAP00000012183	ENSFCAP00000003163	Beclin 1.	Hypoxia inducible factor 1 subunit alpha.	0.497
BECN1	PINK1	ENSFCAP00000012183	ENSFCAP00000000737	Beclin 1.	PTEN induced kinase 1.	0.991
BECN1	PRKN	ENSFCAP00000012183	ENSFCAP00000043123	Beclin 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.859
BECN1	TP53	ENSFCAP00000012183	ENSFCAP00000045749	Beclin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.702
ENSFCAP00000044386	ATG5	ENSFCAP00000044386	ENSFCAP00000046882	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.437
ENSFCAP00000044386	BECN1	ENSFCAP00000044386	ENSFCAP00000012183	Uncharacterized protein.	Beclin 1.	0.455
ENSFCAP00000044386	HIF1A	ENSFCAP00000044386	ENSFCAP00000003163	Uncharacterized protein.	Hypoxia inducible factor 1 subunit alpha.	0.527
ENSFCAP00000044386	HK2	ENSFCAP00000044386	ENSFCAP00000005556	Uncharacterized protein.	Hexokinase 2.	0.612
ENSFCAP00000044386	PLIN5	ENSFCAP00000044386	ENSFCAP00000015975	Uncharacterized protein.	Perilipin; Belongs to the perilipin family.	0.558
ENSFCAP00000044386	TP53	ENSFCAP00000044386	ENSFCAP00000045749	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.648
HIF1A	ATG5	ENSFCAP00000003163	ENSFCAP00000046882	Hypoxia inducible factor 1 subunit alpha.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.459