52 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RC3H1	Ring finger and CCCH-type domains 1. (1133 aa)
	CCL19	C-C motif chemokine. (115 aa)
	SOCS1	Suppressor of cytokine signaling 1. (203 aa)
	LOC101100430	Galectin. (138 aa)
	LOC101081130	AIG1-type G domain-containing protein. (309 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (390 aa)
	NDFIP1	Nedd4 family interacting protein 1. (224 aa)
	NFKBIZ	NFKB inhibitor zeta. (956 aa)
	LOC101083890	Ig-like domain-containing protein. (285 aa)
	PRKCZ	Protein kinase C zeta. (649 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
	AGER	Advanced glycosylation end-product specific receptor. (492 aa)
	SASH3	SAM and SH3 domain containing 3. (379 aa)
	IL2RA	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
	BCL6	BCL6 transcription repressor. (745 aa)
	CD81	Tetraspanin. (236 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	CD160	CD160 molecule. (221 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	ENSFCAP00000060822	Ig-like domain-containing protein. (252 aa)
	ANXA1	Annexin. (407 aa)
	LGALS9	Galectin. (356 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	IL23A	Interleukin 23 subunit alpha. (196 aa)
	IL27	Interleukin 27. (236 aa)
	VSIR	V-set immunoregulatory receptor. (311 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
	MALT1	MALT1 paracaspase. (848 aa)
	ARG2	Arginase. (354 aa)
	CD28	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	ZBTB7B	Uncharacterized protein. (540 aa)
	SH3RF1	SH3 domain containing ring finger 1. (889 aa)
	NLRP3	NLR family pyrin domain containing 3. (1038 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	CBLB	Cbl proto-oncogene B. (1182 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
	CD83	CD83 molecule. (391 aa)
	HLX	H2.0 like homeobox. (569 aa)
	CARD11	Caspase recruitment domain family member 11. (1163 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	NCKAP1L	NCK associated protein 1 like. (1179 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	FOXP3	Forkhead box P3. (501 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CBFB	Uncharacterized protein. (187 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1132 aa)
	SHB	SH2 domain-containing protein. (508 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	HMGB1	ENSFCAP00000004183	ENSFCAP00000058007	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.727
ANXA1	CD81	ENSFCAP00000060870	ENSFCAP00000006444	Annexin.	Tetraspanin.	0.552
ARG2	IFNG	ENSFCAP00000013066	ENSFCAP00000008355	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.584
ARG2	IL4	ENSFCAP00000013066	ENSFCAP00000002290	Arginase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.625
BCL6	CARD11	ENSFCAP00000006325	ENSFCAP00000034539	BCL6 transcription repressor.	Caspase recruitment domain family member 11.	0.431
BCL6	FOXP3	ENSFCAP00000006325	ENSFCAP00000043740	BCL6 transcription repressor.	Forkhead box P3.	0.847
BCL6	GATA3	ENSFCAP00000006325	ENSFCAP00000044199	BCL6 transcription repressor.	GATA binding protein 3.	0.609
BCL6	IFNG	ENSFCAP00000006325	ENSFCAP00000008355	BCL6 transcription repressor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.610
BCL6	IL2	ENSFCAP00000006325	ENSFCAP00000012696	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.534
BCL6	IL4	ENSFCAP00000006325	ENSFCAP00000002290	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.829
BCL6	TBX21	ENSFCAP00000006325	ENSFCAP00000009847	BCL6 transcription repressor.	T-box transcription factor 21.	0.620
CARD11	BCL6	ENSFCAP00000034539	ENSFCAP00000006325	Caspase recruitment domain family member 11.	BCL6 transcription repressor.	0.431
CARD11	MALT1	ENSFCAP00000034539	ENSFCAP00000012971	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.985
CARD11	PRKCQ	ENSFCAP00000034539	ENSFCAP00000041019	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.993
CARD11	RIPK2	ENSFCAP00000034539	ENSFCAP00000016295	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.566
CBFB	FOXP3	ENSFCAP00000045631	ENSFCAP00000043740	Uncharacterized protein.	Forkhead box P3.	0.607
CBFB	GATA3	ENSFCAP00000045631	ENSFCAP00000044199	Uncharacterized protein.	GATA binding protein 3.	0.579
CBLB	RIPK2	ENSFCAP00000026554	ENSFCAP00000016295	Cbl proto-oncogene B.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.414
CCL19	IFNG	ENSFCAP00000061657	ENSFCAP00000008355	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.600
CCL19	IL2	ENSFCAP00000061657	ENSFCAP00000012696	C-C motif chemokine.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.455