STRINGSTRING
BAX BAX SERINC3 SERINC3 TRAF2 TRAF2 FBXW7 FBXW7 S100A8 S100A8 DDIT3 DDIT3 NCK2 NCK2 RACK1 RACK1 PML PML S100A9 S100A9 RBCK1 RBCK1 PEA15 PEA15 BCAP31 BCAP31 IFNB1 IFNB1 RNF183 RNF183 RIPK3 RIPK3 IL19 IL19 PDIA3 PDIA3 NOX1 NOX1 HTRA2 HTRA2 LTBR LTBR FBH1 FBH1 NACC2 NACC2 THBS1 THBS1 RPS3 RPS3 NUPR1 NUPR1 WWOX WWOX BECN1 BECN1 CLU CLU RIPK1 RIPK1 PIAS4 PIAS4 PTEN PTEN PAK2 PAK2 PLEKHF1 PLEKHF1 ZSWIM2 ZSWIM2 IL20RA IL20RA STK4 STK4 PARK7 PARK7 STYXL1 STYXL1 ADORA2A ADORA2A AGT AGT MCL1 MCL1 TRIM60 TRIM60 LOC101098376 LOC101098376 PLAGL2 PLAGL2 ATF3 ATF3 FAS FAS SIRT1 SIRT1 TP63 TP63 ENSFCAP00000028212 ENSFCAP00000028212 DAB2IP DAB2IP GSDME GSDME CAV1 CAV1 TIMP3 TIMP3 ENSFCAP00000030239 ENSFCAP00000030239 ENSFCAP00000030321 ENSFCAP00000030321 ENSFCAP00000030418 ENSFCAP00000030418 CYLD CYLD ENSFCAP00000031202 ENSFCAP00000031202 CASP2 CASP2 DEDD2 DEDD2 FBXW9 FBXW9 SLC9A3R1 SLC9A3R1 SFRP1 SFRP1 PRKRA PRKRA SKIL SKIL NCK1 NCK1 BMPR1B BMPR1B INHBB INHBB FIS1 FIS1 RAD9A RAD9A TRIM75P TRIM75P FLCN FLCN G0S2 G0S2 PTPN2 PTPN2 GPER1 GPER1 NGFR NGFR FADD FADD MYC MYC INHBA INHBA TNFRSF12A TNFRSF12A TP53 TP53 BBC3 BBC3 SFPQ SFPQ BAD BAD MAPK9 MAPK9 TGFBR1 TGFBR1 MSX1 MSX1 PMAIP1 PMAIP1 NFATC4 NFATC4 BCL10 BCL10 EEF1E1 EEF1E1 PYCARD PYCARD TNF TNF TNFSF10 TNFSF10 TRIM39 TRIM39 INCA1 INCA1 ENSFCAP00000051748 ENSFCAP00000051748 NKX3-1 NKX3-1 BCLAF1 BCLAF1 NF1 NF1 BID BID PTPRC PTPRC PPP2R1B PPP2R1B ENSFCAP00000057195 ENSFCAP00000057195 BOK BOK ENSFCAP00000057489 ENSFCAP00000057489 ENSFCAP00000057832 ENSFCAP00000057832 CTSH CTSH ING5 ING5 TRAF7 TRAF7 STK3 STK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
SERINC3Serine incorporator 3. (473 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
FBXW7F-box and WD repeat domain containing 7. (749 aa)
S100A8Protein S100; Belongs to the S-100 family. (124 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
NCK2Cytoplasmic protein. (380 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (424 aa)
PMLPromyelocytic leukemia. (876 aa)
S100A9Protein S100; Belongs to the S-100 family. (135 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (551 aa)
PEA15DED domain-containing protein. (130 aa)
BCAP31B cell receptor associated protein 31. (370 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
RNF183Ring finger protein 183. (190 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (509 aa)
IL19Interleukin 19. (177 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
NOX1NADPH oxidase 1. (564 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
LTBRLymphotoxin beta receptor. (433 aa)
FBH1F-box DNA helicase 1. (1065 aa)
NACC2NACC family member 2. (581 aa)
THBS1Thrombospondin 1. (1170 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
BECN1Beclin 1. (448 aa)
CLUClusterin; Belongs to the clusterin family. (469 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (280 aa)
ZSWIM2Zinc finger SWIM-type containing 2. (634 aa)
IL20RAInterleukin 20 receptor subunit alpha. (712 aa)
STK4Serine/threonine kinase 4. (487 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
STYXL1Serine/threonine/tyrosine interacting like 1. (311 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
TRIM60Tripartite motif containing 60. (471 aa)
LOC101098376Uncharacterized protein. (473 aa)
PLAGL2PLAG1 like zinc finger 2. (496 aa)
ATF3Activating transcription factor 3. (259 aa)
FASUncharacterized protein. (314 aa)
SIRT1Sirtuin 1. (745 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSFCAP00000028212Uncharacterized protein. (83 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
GSDMEGasdermin E. (495 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
ENSFCAP00000030239Uncharacterized protein. (145 aa)
ENSFCAP00000030321Uncharacterized protein. (79 aa)
ENSFCAP00000030418KH type-2 domain-containing protein. (147 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (982 aa)
ENSFCAP00000031202Uncharacterized protein. (94 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (451 aa)
DEDD2Death effector domain containing 2. (327 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (313 aa)
SKILSKI like proto-oncogene. (686 aa)
NCK1Cytoplasmic protein. (455 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
INHBBInhibin subunit beta B. (407 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
RAD9ARAD9 checkpoint clamp component A. (641 aa)
TRIM75PTripartite motif containing 75, pseudogene. (469 aa)
FLCNUncharacterized protein. (579 aa)
G0S2G0/G1 switch 2. (102 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
NGFRNerve growth factor receptor. (421 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
TNFRSF12ATNF receptor superfamily member 12A. (129 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
BBC3Uncharacterized protein. (193 aa)
SFPQSplicing factor proline and glutamine rich. (701 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
MSX1Msh homeobox 1. (303 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
NFATC4Nuclear factor of activated T cells 4. (930 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
EEF1E1Uncharacterized protein. (250 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
TRIM39Tripartite motif containing 39. (517 aa)
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (256 aa)
ENSFCAP00000051748Uncharacterized protein. (59 aa)
NKX3-1NK3 homeobox 1. (231 aa)
BCLAF1Uncharacterized protein. (948 aa)
NF1Neurofibromin 1. (2856 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
ENSFCAP00000057195Uncharacterized protein. (34 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
ENSFCAP00000057489Uncharacterized protein. (192 aa)
ENSFCAP00000057832Uncharacterized protein. (124 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (572 aa)
ING5Inhibitor of growth family member 5. (293 aa)
TRAF7TNF receptor associated factor 7. (825 aa)
STK3Serine/threonine kinase 3. (573 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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