STRINGSTRING
EYA1 EYA1 TRAF2 TRAF2 TMBIM1 TMBIM1 IL4 IL4 PML PML RBCK1 RBCK1 CSF2 CSF2 PEA15 PEA15 HTT HTT CTTN CTTN IL1B IL1B BIRC6 BIRC6 IL19 IL19 PDIA3 PDIA3 GFRAL GFRAL HTRA2 HTRA2 AR AR LTBR LTBR MAPK7 MAPK7 PHIP PHIP RB1CC1 RB1CC1 ZC3HC1 ZC3HC1 GATA1 GATA1 DEPTOR DEPTOR THBS1 THBS1 LMNA LMNA WWOX WWOX FGB FGB COL2A1 COL2A1 RIPK1 RIPK1 TMC8 TMC8 PTEN PTEN ITPRIPL2 ITPRIPL2 PAK2 PAK2 SCG2 SCG2 SH3RF1 SH3RF1 ZSWIM2 ZSWIM2 SGK3 SGK3 DDX3X DDX3X STK4 STK4 PARK7 PARK7 RPS6KB1 RPS6KB1 AGT AGT MCL1 MCL1 TMBIM7P TMBIM7P UNC5B UNC5B ATF3 ATF3 STRADB STRADB MADD MADD CAV1 CAV1 TIMP3 TIMP3 BCL2L12 BCL2L12 CYLD CYLD PAK5 PAK5 IFI6 IFI6 DEDD2 DEDD2 RAF1 RAF1 IL7 IL7 FGF10 FGF10 GDNF GDNF ARHGEF2 ARHGEF2 ENSFCAP00000033605 ENSFCAP00000033605 HGF HGF EYA3 EYA3 SFRP1 SFRP1 ITGA6 ITGA6 SKIL SKIL ZMYND11 ZMYND11 RNF34 RNF34 BMPR1B BMPR1B SFRP2 SFRP2 BCL2L14 BCL2L14 LGALS3 LGALS3 SRC SRC FAIM FAIM G0S2 G0S2 GCLM GCLM CFLAR CFLAR SIAH2 SIAH2 GSK3B GSK3B GPER1 GPER1 FADD FADD PELI3 PELI3 INHBA INHBA TNFRSF12A TNFRSF12A FEM1B FEM1B TGFBR1 TGFBR1 RELA RELA YAP1 YAP1 PMAIP1 PMAIP1 EYA4 EYA4 BCL10 BCL10 PYCARD PYCARD TNF TNF BMP4 BMP4 TNFSF10 TNFSF10 ITGAV ITGAV PSME3 PSME3 TRAF1 TRAF1 ENSFCAP00000053469 ENSFCAP00000053469 ITPRIP ITPRIP NF1 NF1 BID BID PTPRC PTPRC PPP2R1B PPP2R1B EYA2 EYA2 TNFAIP3 TNFAIP3 GAS1 GAS1 ENSFCAP00000057832 ENSFCAP00000057832 RFFL RFFL NOL3 NOL3 STK3 STK3 HMOX1 HMOX1 FAIM2 FAIM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
PMLPromyelocytic leukemia. (876 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (551 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
PEA15DED domain-containing protein. (130 aa)
HTTHuntingtin. (3140 aa)
CTTNCortactin. (538 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
BIRC6Baculoviral IAP repeat containing 6. (4862 aa)
IL19Interleukin 19. (177 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
GFRALGDNF family receptor alpha like. (365 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ARAndrogen receptor. (903 aa)
LTBRLymphotoxin beta receptor. (433 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
PHIPPleckstrin homology domain interacting protein. (1821 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
GATA1GATA binding protein 1. (413 aa)
DEPTORDEP domain containing MTOR interacting protein. (411 aa)
THBS1Thrombospondin 1. (1170 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (473 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TMC8Transmembrane channel-like protein. (723 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ITPRIPL2ITPRIP like 2. (532 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
SCG2Secretogranin II. (680 aa)
SH3RF1SH3 domain containing ring finger 1. (889 aa)
ZSWIM2Zinc finger SWIM-type containing 2. (634 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
STK4Serine/threonine kinase 4. (487 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
TMBIM7PUncharacterized protein; Belongs to the BI1 family. (292 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
ATF3Activating transcription factor 3. (259 aa)
STRADBSTE20 related adaptor beta. (415 aa)
MADDMAP kinase activating death domain. (1647 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
BCL2L12BCL2 like 12. (255 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (982 aa)
PAK5Non-specific serine/threonine protein kinase. (725 aa)
IFI6Interferon alpha inducible protein 6. (149 aa)
DEDD2Death effector domain containing 2. (327 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IL7Interleukin 7. (158 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1181 aa)
ENSFCAP00000033605Uncharacterized protein. (147 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
SKILSKI like proto-oncogene. (686 aa)
ZMYND11Zinc finger MYND-type containing 11. (617 aa)
RNF34Ring finger protein 34. (382 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
BCL2L14BCL2 like 14. (348 aa)
LGALS3Galectin. (278 aa)
SRCTyrosine-protein kinase. (678 aa)
FAIMFas apoptotic inhibitory molecule. (201 aa)
G0S2G0/G1 switch 2. (102 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
TNFRSF12ATNF receptor superfamily member 12A. (129 aa)
FEM1BFem-1 homolog B. (627 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
YAP1Yes associated protein 1. (498 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
PSME3Uncharacterized protein. (265 aa)
TRAF1TNF receptor-associated factor. (433 aa)
ENSFCAP00000053469PA28_beta domain-containing protein. (192 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (552 aa)
NF1Neurofibromin 1. (2856 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (657 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
GAS1Growth arrest specific 1. (369 aa)
ENSFCAP00000057832Uncharacterized protein. (124 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (528 aa)
NOL3Nucleolar protein 3. (218 aa)
STK3Serine/threonine kinase 3. (573 aa)
HMOX1Heme oxygenase 1. (404 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (335 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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