STRINGSTRING
EYA1 EYA1 CSF2 CSF2 IL1B IL1B GFRAL GFRAL HTRA2 HTRA2 MAPK7 MAPK7 ZC3HC1 ZC3HC1 GATA1 GATA1 WWOX WWOX COL2A1 COL2A1 RIPK1 RIPK1 SGK3 SGK3 GAS1 GAS1 EYA2 EYA2 PPP2R1B PPP2R1B NF1 NF1 TNF TNF EYA4 EYA4 INHBA INHBA EYA3 EYA3 ENSFCAP00000033605 ENSFCAP00000033605 GDNF GDNF FGF10 FGF10 IL7 IL7 IFI6 IFI6 STRADB STRADB UNC5B UNC5B MCL1 MCL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
GFRALGDNF family receptor alpha like. (365 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
GATA1GATA binding protein 1. (413 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GAS1Growth arrest specific 1. (369 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (657 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
NF1Neurofibromin 1. (2856 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
ENSFCAP00000033605Uncharacterized protein. (147 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
IL7Interleukin 7. (158 aa)
IFI6Interferon alpha inducible protein 6. (149 aa)
STRADBSTE20 related adaptor beta. (415 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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