56 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	S100A9	Protein S100; Belongs to the S-100 family. (135 aa)
	BOK	BCL2 family apoptosis regulator BOK. (320 aa)
	ENSFCAP00000057195	Uncharacterized protein. (34 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
	BCLAF1	Uncharacterized protein. (948 aa)
	NKX3-1	NK3 homeobox 1. (231 aa)
	ENSFCAP00000051748	Uncharacterized protein. (59 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	MSX1	Msh homeobox 1. (303 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	SFPQ	Splicing factor proline and glutamine rich. (701 aa)
	BBC3	Uncharacterized protein. (193 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (416 aa)
	FLCN	Uncharacterized protein. (579 aa)
	RAD9A	RAD9 checkpoint clamp component A. (641 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	NCK1	Cytoplasmic protein. (455 aa)
	SKIL	SKI like proto-oncogene. (686 aa)
	PRKRA	Protein activator of interferon induced protein kinase EIF2AK2. (313 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	ENSFCAP00000031202	Uncharacterized protein. (94 aa)
	ENSFCAP00000030418	KH type-2 domain-containing protein. (147 aa)
	ENSFCAP00000030321	Uncharacterized protein. (79 aa)
	ENSFCAP00000030239	Uncharacterized protein. (145 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	GSDME	Gasdermin E. (495 aa)
	ENSFCAP00000028212	Uncharacterized protein. (83 aa)
	SIRT1	Sirtuin 1. (745 aa)
	PLAGL2	PLAG1 like zinc finger 2. (496 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
	STYXL1	Serine/threonine/tyrosine interacting like 1. (311 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	IL20RA	Interleukin 20 receptor subunit alpha. (712 aa)
	PLEKHF1	Pleckstrin homology and FYVE domain containing 1. (280 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (514 aa)
	CLU	Clusterin; Belongs to the clusterin family. (469 aa)
	BECN1	Beclin 1. (448 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	NACC2	NACC family member 2. (581 aa)
	FBH1	F-box DNA helicase 1. (1065 aa)
	NOX1	NADPH oxidase 1. (564 aa)
	IL19	Interleukin 19. (177 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (509 aa)
	RNF183	Ring finger protein 183. (190 aa)
	BCAP31	B cell receptor associated protein 31. (370 aa)
	RACK1	WD_REPEATS_REGION domain-containing protein. (424 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	DDIT3	DNA damage inducible transcript 3. (167 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (124 aa)
	FBXW7	F-box and WD repeat domain containing 7. (749 aa)
	SERINC3	Serine incorporator 3. (473 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAX	ENSFCAP00000047559	ENSFCAP00000000237	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.840
BAD	BID	ENSFCAP00000047559	ENSFCAP00000055705	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.798
BAD	BOK	ENSFCAP00000047559	ENSFCAP00000057223	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	MCL1	ENSFCAP00000047559	ENSFCAP00000023698	BCL2 associated agonist of cell death.	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).	0.780
BAX	BAD	ENSFCAP00000000237	ENSFCAP00000047559	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death.	0.840
BAX	BBC3	ENSFCAP00000000237	ENSFCAP00000046125	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.742
BAX	BECN1	ENSFCAP00000000237	ENSFCAP00000012183	BCL2 associated X, apoptosis regulator.	Beclin 1.	0.541
BAX	BID	ENSFCAP00000000237	ENSFCAP00000055705	BCL2 associated X, apoptosis regulator.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.998
BAX	MCL1	ENSFCAP00000000237	ENSFCAP00000023698	BCL2 associated X, apoptosis regulator.	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).	0.469
BAX	PMAIP1	ENSFCAP00000000237	ENSFCAP00000049753	BCL2 associated X, apoptosis regulator.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.717
BAX	SIRT1	ENSFCAP00000000237	ENSFCAP00000027641	BCL2 associated X, apoptosis regulator.	Sirtuin 1.	0.910
BAX	TP53	ENSFCAP00000000237	ENSFCAP00000045749	BCL2 associated X, apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.411
BBC3	BAX	ENSFCAP00000046125	ENSFCAP00000000237	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.742
BBC3	BID	ENSFCAP00000046125	ENSFCAP00000055705	Uncharacterized protein.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.924
BBC3	BOK	ENSFCAP00000046125	ENSFCAP00000057223	Uncharacterized protein.	BCL2 family apoptosis regulator BOK.	0.586
BBC3	DDIT3	ENSFCAP00000046125	ENSFCAP00000001926	Uncharacterized protein.	DNA damage inducible transcript 3.	0.415
BBC3	MCL1	ENSFCAP00000046125	ENSFCAP00000023698	Uncharacterized protein.	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).	0.941
BBC3	PMAIP1	ENSFCAP00000046125	ENSFCAP00000049753	Uncharacterized protein.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.967
BBC3	TP53	ENSFCAP00000046125	ENSFCAP00000045749	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.686
BCAP31	FIS1	ENSFCAP00000003727	ENSFCAP00000040430	B cell receptor associated protein 31.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.418