(148 nodes) PDZ domain network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRIP1	Glutamate receptor interacting protein 1. (1128 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (935 aa)
	RADIL	Rap associating with DIL domain. (1203 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
	MAGI3	Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1482 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (313 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1047 aa)
	GOPC	PDZ domain-containing protein. (463 aa)
	ENSFCAP00000032180	PDZ domain-containing protein. (221 aa)
	ENSFCAP00000033593	PDZ domain-containing protein. (149 aa)
	PTPN13	Protein tyrosine phosphatase non-receptor type 13. (2491 aa)
	SDCBP2	Syndecan binding protein 2. (287 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	CARD11	Caspase recruitment domain family member 11. (1163 aa)
	LIMK1	LIM domain kinase 1. (763 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (754 aa)
	MAST1	Microtubule associated serine/threonine kinase 1. (1571 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1384 aa)
	PDLIM7	PDZ and LIM domain 7. (458 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (797 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
	SYNPO2L	Synaptopodin 2 like. (973 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	MAGIX	MAGI family member, X-linked. (421 aa)
	MPP2	Uncharacterized protein; Belongs to the MAGUK family. (569 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1180 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (613 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1950 aa)
	PDZRN3	PDZ domain containing ring finger 3. (1063 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (831 aa)
	PDZD7	PDZ domain containing 7. (542 aa)
	GRASP	General receptor for phosphoinositides 1 associated scaffold protein. (547 aa)
	CARD14	Caspase recruitment domain family member 14. (969 aa)
	SCRIB	Scribble planar cell polarity protein. (1637 aa)
	PDZD3	PDZ domain containing 3. (505 aa)
	PDLIM1	PDZ and LIM domain 1. (329 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1591 aa)
	HTRA4	HtrA serine peptidase 4. (476 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	HTRA1	HtrA serine peptidase 1. (484 aa)
	MPP4	Membrane palmitoylated protein 4; Belongs to the MAGUK family. (606 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1647 aa)
	RGS12	Regulator of G protein signaling 12. (1347 aa)
	CNKSR3	CNKSR family member 3. (588 aa)
	PDLIM2	PDZ and LIM domain 2. (418 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1694 aa)
	FRMPD2	FERM and PDZ domain containing 2. (1303 aa)
	SIPA1L1	Signal induced proliferation associated 1 like 1. (1803 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (312 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (910 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	SIPA1L2	Signal induced proliferation associated 1 like 2. (1717 aa)
	MAST3	Microtubule associated serine/threonine kinase 3. (1302 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	PDZD9	PDZ domain containing 9. (264 aa)
	DVL3	Dishevelled segment polarity protein 3. (718 aa)
	LNX1	Ligand of numb-protein X 1. (732 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (345 aa)
	MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1446 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (411 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (935 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
	LNX2	Ligand of numb-protein X 2. (689 aa)
	FRMPD1	FERM and PDZ domain containing 1. (1580 aa)
	CNKSR1	Connector enhancer of kinase suppressor of Ras 1. (722 aa)
	SHROOM3	Shroom family member 3. (1994 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (447 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1366 aa)
	PDZRN4	PDZ domain containing ring finger 4. (1037 aa)
	SNTB2	Syntrophin beta 2. (540 aa)
	PARD6G	Par-6 family cell polarity regulator gamma. (363 aa)
	STXBP4	Uncharacterized protein. (562 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1452 aa)
	DVL2	Dishevelled segment polarity protein 2. (735 aa)
	SHROOM2	Shroom family member 2. (1605 aa)
	ERBIN	Erbb2 interacting protein. (1461 aa)
	WHRN	Whirlin. (918 aa)
	USH1C	USH1 protein network component harmonin. (899 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1700 aa)
	PARD6B	Par-6 family cell polarity regulator beta. (370 aa)
	SNTG2	Syntrophin gamma 2. (531 aa)
	PDLIM4	PDZ and LIM domain 4. (330 aa)
	MAST2	Microtubule associated serine/threonine kinase 2. (1799 aa)
	SIPA1L3	Signal induced proliferation associated 1 like 3. (1776 aa)
	RHPN2	Rhophilin Rho GTPase binding protein 2. (686 aa)
	HTRA3	HtrA serine peptidase 3. (453 aa)
	SHROOM4	Shroom family member 4. (1561 aa)
	GRID2IP	Grid2 interacting protein. (1211 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	PDZD8	PDZ domain containing 8. (1154 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (610 aa)
	SIPA1	Signal-induced proliferation-associated 1. (1047 aa)
	LOC109502572	Uncharacterized protein. (1274 aa)
	PSMD9	Proteasome 26S subunit, non-ATPase 9. (284 aa)
	SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5213 aa)
	CYTIP	Cytohesin 1 interacting protein. (356 aa)
	PRX	Periaxin. (1482 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
	MPP6	Membrane palmitoylated protein 6; Belongs to the MAGUK family. (560 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1657 aa)
	SHANK3	Uncharacterized protein. (405 aa)
	AFDN	Afadin, adherens junction formation factor. (1873 aa)
	LIMK2	LIM domain kinase 2. (711 aa)
	FRMPD4	FERM and PDZ domain containing 4. (1358 aa)
	RHPN1	Rhophilin Rho GTPase binding protein 1. (760 aa)
	LMO7	LIM domain 7. (1787 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1375 aa)
	RAPGEF6	Uncharacterized protein. (1623 aa)
	RGS3	Regulator of G protein signaling 3. (904 aa)
	PATJ	PATJ crumbs cell polarity complex component. (1872 aa)
	NOS1	Nitric oxide synthase 1. (1462 aa)
	ENSFCAP00000054650	Uncharacterized protein. (310 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (889 aa)
	PARD3	Par-3 family cell polarity regulator. (1417 aa)
	SNX27	Sorting nexin 27. (541 aa)
	KIAA1614	KIAA1614. (1203 aa)
	MPP1	Uncharacterized protein; Belongs to the MAGUK family. (519 aa)
	LRRC7	Leucine rich repeat containing 7. (1575 aa)
	PDZK1	PDZ domain containing 1. (584 aa)
	PDLIM5	PDZ and LIM domain 5. (646 aa)
	SNTB1	Syntrophin beta 1. (532 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
	SNTG1	Syntrophin gamma 1. (562 aa)
	ARHGAP23	Rho GTPase activating protein 23. (1495 aa)
	PARD3B	Par-3 family cell polarity regulator beta. (1202 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1692 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (1012 aa)
	SYNJ2BP	Synaptojanin 2 binding protein. (145 aa)
	PDZD11	PDZ domain containing 11. (179 aa)
	SNTA1	Syntrophin alpha 1. (505 aa)
	FRMPD3	FERM and PDZ domain containing 3. (1779 aa)
	SDCBP	Syndecan binding protein. (298 aa)
	MYO18A	Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2066 aa)
	PDZD2	PDZ domain containing 2. (2833 aa)
	SYNPO2	Synaptopodin 2. (1263 aa)
	PTPN4	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1849 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1543 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (2081 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
	CNKSR2	Connector enhancer of kinase suppressor of Ras 2. (1036 aa)
	PDLIM3	PDZ and LIM domain 3. (364 aa)
	LDB3	LIM domain binding 3. (723 aa)
	INTU	Inturned planar cell polarity protein. (890 aa)
	TAX1BP3	Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	ERBIN	ENSFCAP00000058308	ENSFCAP00000045828	Afadin, adherens junction formation factor.	Erbb2 interacting protein.	0.466
AFDN	LMO7	ENSFCAP00000058308	ENSFCAP00000056896	Afadin, adherens junction formation factor.	LIM domain 7.	0.950
AFDN	PDZD11	ENSFCAP00000058308	ENSFCAP00000048565	Afadin, adherens junction formation factor.	PDZ domain containing 11.	0.489
AFDN	RAPGEF2	ENSFCAP00000058308	ENSFCAP00000044742	Afadin, adherens junction formation factor.	Rap guanine nucleotide exchange factor 2.	0.543
AFDN	SIPA1	ENSFCAP00000058308	ENSFCAP00000016329	Afadin, adherens junction formation factor.	Signal-induced proliferation-associated 1.	0.923
AFDN	TJP1	ENSFCAP00000058308	ENSFCAP00000027327	Afadin, adherens junction formation factor.	Tight junction protein 1; Belongs to the MAGUK family.	0.961
AFDN	TJP2	ENSFCAP00000058308	ENSFCAP00000040989	Afadin, adherens junction formation factor.	Uncharacterized protein; Belongs to the MAGUK family.	0.963
AFDN	TJP3	ENSFCAP00000058308	ENSFCAP00000006622	Afadin, adherens junction formation factor.	Tight junction protein 3; Belongs to the MAGUK family.	0.575
APBA1	CASK	ENSFCAP00000042819	ENSFCAP00000029742	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.992
APBA1	DLG1	ENSFCAP00000042819	ENSFCAP00000050965	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.405
APBA1	DLG2	ENSFCAP00000042819	ENSFCAP00000048751	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 2.	0.405
APBA1	DLG5	ENSFCAP00000042819	ENSFCAP00000037125	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.401
APBA1	ENSFCAP00000032180	ENSFCAP00000042819	ENSFCAP00000032180	Amyloid beta precursor protein binding family A member 1.	PDZ domain-containing protein.	0.735
APBA1	LIN7A	ENSFCAP00000042819	ENSFCAP00000030507	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.779
APBA1	LIN7B	ENSFCAP00000042819	ENSFCAP00000015859	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.709
APBA1	LIN7C	ENSFCAP00000042819	ENSFCAP00000038001	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.709
APBA1	MAGI3	ENSFCAP00000042819	ENSFCAP00000030857	Amyloid beta precursor protein binding family A member 1.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.497
APBA1	MPP1	ENSFCAP00000042819	ENSFCAP00000053463	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the MAGUK family.	0.735
APBA1	MPP2	ENSFCAP00000042819	ENSFCAP00000040477	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the MAGUK family.	0.624
APBA1	MPP3	ENSFCAP00000042819	ENSFCAP00000041726	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 3; Belongs to the MAGUK family.	0.481