node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESR1 | ESR2 | ENSFCAP00000020448 | ENSFCAP00000042538 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen receptor 2. | 0.997 |
ESR1 | ESRRA | ENSFCAP00000020448 | ENSFCAP00000020994 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen related receptor alpha. | 0.414 |
ESR1 | NR3C1 | ENSFCAP00000020448 | ENSFCAP00000019629 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Uncharacterized protein. | 0.421 |
ESR1 | NR5A1 | ENSFCAP00000020448 | ENSFCAP00000049244 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor subfamily 5 group A member 1. | 0.520 |
ESR1 | NR5A2 | ENSFCAP00000020448 | ENSFCAP00000040336 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor subfamily 5 group A member 2. | 0.472 |
ESR1 | PGR | ENSFCAP00000020448 | ENSFCAP00000049487 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Progesterone receptor. | 0.981 |
ESR1 | PPARG | ENSFCAP00000020448 | ENSFCAP00000050722 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.469 |
ESR2 | ESR1 | ENSFCAP00000042538 | ENSFCAP00000020448 | Estrogen receptor 2. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.997 |
ESR2 | ESRRB | ENSFCAP00000042538 | ENSFCAP00000061586 | Estrogen receptor 2. | Estrogen related receptor beta. | 0.512 |
ESR2 | ESRRG | ENSFCAP00000042538 | ENSFCAP00000058017 | Estrogen receptor 2. | Estrogen related receptor gamma. | 0.438 |
ESR2 | NR5A1 | ENSFCAP00000042538 | ENSFCAP00000049244 | Estrogen receptor 2. | Nuclear receptor subfamily 5 group A member 1. | 0.496 |
ESR2 | NR5A2 | ENSFCAP00000042538 | ENSFCAP00000040336 | Estrogen receptor 2. | Nuclear receptor subfamily 5 group A member 2. | 0.440 |
ESR2 | PGR | ENSFCAP00000042538 | ENSFCAP00000049487 | Estrogen receptor 2. | Progesterone receptor. | 0.867 |
ESRRA | ESR1 | ENSFCAP00000020994 | ENSFCAP00000020448 | Estrogen related receptor alpha. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.414 |
ESRRA | ESRRB | ENSFCAP00000020994 | ENSFCAP00000061586 | Estrogen related receptor alpha. | Estrogen related receptor beta. | 0.615 |
ESRRA | ESRRG | ENSFCAP00000020994 | ENSFCAP00000058017 | Estrogen related receptor alpha. | Estrogen related receptor gamma. | 0.589 |
ESRRA | PPARG | ENSFCAP00000020994 | ENSFCAP00000050722 | Estrogen related receptor alpha. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.461 |
ESRRB | ESR2 | ENSFCAP00000061586 | ENSFCAP00000042538 | Estrogen related receptor beta. | Estrogen receptor 2. | 0.512 |
ESRRB | ESRRA | ENSFCAP00000061586 | ENSFCAP00000020994 | Estrogen related receptor beta. | Estrogen related receptor alpha. | 0.615 |
ESRRB | ESRRG | ENSFCAP00000061586 | ENSFCAP00000058017 | Estrogen related receptor beta. | Estrogen related receptor gamma. | 0.444 |