(25 nodes) Complement Clr-like EGF domain network (Felis catus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MATN4	Matrilin 4. (843 aa)
	NID2	Nidogen 2. (1401 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
	SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2. (1024 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (504 aa)
	FBLN5	Fibulin 5. (491 aa)
	CD93	CD93 molecule. (750 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1302 aa)
	LRP2	LDL receptor related protein 2. (4646 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1823 aa)
	FBLN2	Fibulin 2. (1223 aa)
	FBN2	Fibrillin 2. (2912 aa)
	NID1	Nidogen 1. (1244 aa)
	FBN3	Fibrillin 3. (2831 aa)
	FBN1	Fibrillin 1. (2871 aa)
	LRP1B	LDL receptor related protein 1B. (4599 aa)
	HMCN1	Hemicentin 1. (5635 aa)
	LRP1	LDL receptor related protein 1. (4561 aa)
	HMCN2	Hemicentin 2. (4978 aa)
	VWCE	Von Willebrand factor C and EGF domains. (931 aa)
	SCUBE1	Signal peptide, CUB domain and EGF like domain containing 1. (1017 aa)
	LRP4	LDL receptor related protein 4. (1905 aa)
	SCUBE3	Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (443 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFEMP2	FBN1	ENSFCAP00000044801	ENSFCAP00000014241	EGF containing fibulin extracellular matrix protein 2.	Fibrillin 1.	0.414
EGF	LRP2	ENSFCAP00000059920	ENSFCAP00000005687	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	LDL receptor related protein 2.	0.410
FBLN1	FBLN2	ENSFCAP00000050071	ENSFCAP00000006954	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Fibulin 2.	0.594
FBLN1	FBN1	ENSFCAP00000050071	ENSFCAP00000014241	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Fibrillin 1.	0.477
FBLN1	NID2	ENSFCAP00000050071	ENSFCAP00000048610	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Nidogen 2.	0.426
FBLN2	FBLN1	ENSFCAP00000006954	ENSFCAP00000050071	Fibulin 2.	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	0.594
FBLN2	FBN1	ENSFCAP00000006954	ENSFCAP00000014241	Fibulin 2.	Fibrillin 1.	0.593
FBLN2	NID1	ENSFCAP00000006954	ENSFCAP00000010245	Fibulin 2.	Nidogen 1.	0.466
FBLN2	NID2	ENSFCAP00000006954	ENSFCAP00000048610	Fibulin 2.	Nidogen 2.	0.596
FBLN5	FBN1	ENSFCAP00000056606	ENSFCAP00000014241	Fibulin 5.	Fibrillin 1.	0.461
FBLN5	LTBP2	ENSFCAP00000056606	ENSFCAP00000005918	Fibulin 5.	Latent transforming growth factor beta binding protein 2.	0.419
FBN1	EFEMP2	ENSFCAP00000014241	ENSFCAP00000044801	Fibrillin 1.	EGF containing fibulin extracellular matrix protein 2.	0.414
FBN1	FBLN1	ENSFCAP00000014241	ENSFCAP00000050071	Fibrillin 1.	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	0.477
FBN1	FBLN2	ENSFCAP00000014241	ENSFCAP00000006954	Fibrillin 1.	Fibulin 2.	0.593
FBN1	FBLN5	ENSFCAP00000014241	ENSFCAP00000056606	Fibrillin 1.	Fibulin 5.	0.461
FBN1	FBN2	ENSFCAP00000014241	ENSFCAP00000008983	Fibrillin 1.	Fibrillin 2.	0.616
FBN1	FBN3	ENSFCAP00000014241	ENSFCAP00000013867	Fibrillin 1.	Fibrillin 3.	0.620
FBN1	LTBP2	ENSFCAP00000014241	ENSFCAP00000005918	Fibrillin 1.	Latent transforming growth factor beta binding protein 2.	0.470
FBN1	NID1	ENSFCAP00000014241	ENSFCAP00000010245	Fibrillin 1.	Nidogen 1.	0.475
FBN2	FBN1	ENSFCAP00000008983	ENSFCAP00000014241	Fibrillin 2.	Fibrillin 1.	0.616