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BMP6 BMP6 GDF6 GDF6 PDGFA PDGFA FGF12 FGF12 IL6 IL6 FGF9 FGF9 BMP15 BMP15 FGF7 FGF7 FGF16 FGF16 GDF11 GDF11 FGF13 FGF13 MSTN MSTN PDGFB PDGFB TGFB3 TGFB3 IL2 IL2 GDF9 GDF9 CXCL12 CXCL12 ENSFCAP00000061110 ENSFCAP00000061110 BMP4 BMP4 GDF7 GDF7 FGF1 FGF1 FGF17 FGF17 FGF22 FGF22 PDGFC PDGFC LOC105261327 LOC105261327 IL5 IL5 EGF EGF PSPN PSPN KITLG KITLG FGF20 FGF20 GMFB GMFB BMP8A BMP8A IL12A IL12A CSF1 CSF1 GDF3 GDF3 GDF15 GDF15 VEGFC VEGFC BMP3 BMP3 FGF21 FGF21 FGF8 FGF8 NTF3 NTF3 INHA INHA VEGFB VEGFB TGFB1 TGFB1 BMP5 BMP5 CSF2 CSF2 INHBB INHBB FGF19 FGF19 CSF3 CSF3 FGF14 FGF14 GDF5 GDF5 HGF HGF GDNF GDNF FGF4 FGF4 FGF10 FGF10 TGFB2 TGFB2 BMP2 BMP2 INHBC INHBC GDF10 GDF10 BMP10 BMP10 INHBE INHBE IL4 IL4 NODAL NODAL NTF4 NTF4 FGF6 FGF6 VEGFA VEGFA BMP8B BMP8B BDNF BDNF FGF23 FGF23 FGF18 FGF18 ARTN ARTN NRTN NRTN FGF3 FGF3 PGF PGF LOC101092676 LOC101092676 INHBA INHBA NGF NGF FGF11 FGF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (502 aa)
GDF6TGF_BETA_2 domain-containing protein. (462 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GDF11Growth differentiation factor 11. (404 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
MSTNMyostatin. (375 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
GDF9Growth differentiation factor 9. (452 aa)
CXCL12Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
ENSFCAP00000061110TGF_BETA_2 domain-containing protein. (362 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GDF7Growth differentiation factor 7. (455 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC105261327Left-right determination factor. (367 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
PSPNPersephin. (146 aa)
KITLGSoluble KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). (274 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (143 aa)
BMP8ATGF_BETA_2 domain-containing protein. (402 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
GDF3Growth differentiation factor 3. (365 aa)
GDF15Growth differentiation factor 15. (307 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
INHBBInhibin subunit beta B. (407 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. (204 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (303 aa)
GDF5Growth differentiation factor 5. (499 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
INHBCInhibin subunit beta C. (353 aa)
GDF10Growth differentiation factor 10. (503 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
INHBEInhibin subunit beta E. (349 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
NODALNodal growth differentiation factor. (348 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
ARTNArtemin. (220 aa)
NRTNNeurturin. (197 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (290 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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