144 items (Felis catus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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co-expression

protein homology

Your Input:
	LOC101098213	Cytochrome c. (105 aa)
	CNRIP1	Uncharacterized protein. (324 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
	DYNLL1	Dynein light chain. (89 aa)
	ENSFCAP00000037707	Uncharacterized protein. (182 aa)
	APC	APC regulator of WNT signaling pathway. (2874 aa)
	SATB1	DNA-binding protein SATB. (792 aa)
	DYNLL2	Dynein light chain. (89 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1180 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	PLEC	Plectin. (4686 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (523 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2289 aa)
	DAPK3	Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
	DIABLO	Uncharacterized protein. (237 aa)
	ENSFCAP00000033453	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	MAPT	Microtubule-associated protein. (778 aa)
	BCL2L10	Uncharacterized protein. (192 aa)
	DUS4L	Uncharacterized protein. (482 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa)
	BCL2L2	BCL2 like 2. (193 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
	TRADD	TNFRSF1A associated via death domain. (311 aa)
	SH3GLB2	SH3 domain containing GRB2 like, endophilin B2. (480 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (69 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	DSG1	Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1074 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	CDH1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
	BCL2	BCL2 apoptosis regulator. (237 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (252 aa)
	DBNL	Drebrin like. (522 aa)
	MAP2	Microtubule-associated protein. (1895 aa)
	BAK1	BCL2 antagonist/killer 1. (251 aa)
	YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (301 aa)
	HMGB4	High mobility group box 4. (193 aa)
	SEPTIN1	Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (505 aa)
	BCL2L1	BCL2 like 1. (271 aa)
	GSDMD	Gasdermin D. (531 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (409 aa)
	BOK	BCL2 family apoptosis regulator BOK. (320 aa)
	ENSFCAP00000057050	Gasdermin domain-containing protein. (205 aa)
	DSG2	Desmoglein 2. (1330 aa)
	DFFA	DNA fragmentation factor subunit alpha. (370 aa)
	ENSFCAP00000056245	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (178 aa)
	AVEN	Apoptosis and caspase activation inhibitor. (356 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	HP1BP3	Heterochromatin protein 1 binding protein 3. (553 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
	ACIN1	Apoptotic chromatin condensation inducer 1. (1339 aa)
	APIP	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa)
	STK25	Serine/threonine kinase 25. (426 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	CAPG	Capping actin protein, gelsolin like. (388 aa)
	CTNNB1	Catenin beta 1. (783 aa)
	H1-2	Histone cluster 1 H1 family member c. (331 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	BCAP31	B cell receptor associated protein 31. (370 aa)
	HMGB2	High mobility group box 2. (210 aa)
	LOC101096522	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
	PKP1	Plakophilin 1. (727 aa)
	SCIN	Scinderin. (715 aa)
	DAPK1	Death associated protein kinase 1. (1429 aa)
	NMT1	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (539 aa)
	H1-1	Histone cluster 1 H1 family member a. (214 aa)
	H1-6	Histone cluster 1 H1 family member t. (211 aa)
	H1-5	Histone cluster 1 H1 family member b. (226 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	H1-3	Histone cluster 1 H1 family member d. (222 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (910 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	NPVF	Neuropeptide VF precursor. (197 aa)
	SEPTIN4	Septin 4. (535 aa)
	TEX14	Testis expressed 14, intercellular bridge forming factor. (1483 aa)
	DSP	Desmoplakin. (2884 aa)
	BMX	Tyrosine-protein kinase. (630 aa)
	IGDCC3	Immunoglobulin superfamily DCC subclass member 3. (806 aa)
	IGDCC4	Immunoglobulin superfamily DCC subclass member 4. (1249 aa)
	DFFB	DNA fragmentation factor subunit beta. (647 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	XIAP	X-linked inhibitor of apoptosis. (454 aa)
	DCC	DCC netrin 1 receptor. (1446 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	GSDMA	Gasdermin A. (445 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (452 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (451 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	STK26	Serine/threonine kinase 26. (416 aa)
	M3X2M0_FELCA	Uncharacterized protein. (175 aa)
	DSG3	Desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (985 aa)
	H1-0	H1 histone family member 0. (231 aa)
	LOC101100947	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (401 aa)
	ADD1	Adducin 1. (761 aa)
	UNC5B	Unc-5 netrin receptor B. (945 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
	FAS	Uncharacterized protein. (314 aa)
	ENSFCAP00000026949	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (135 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
	ENSFCAP00000027328	Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (103 aa)
	CLSPN	Claspin. (1327 aa)
	ENSFCAP00000027525	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HMGB3	Uncharacterized protein. (271 aa)
	ENSFCAP00000028410	Uncharacterized protein. (195 aa)
	GSDME	Gasdermin E. (495 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (289 aa)
	SEPTIN5	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (463 aa)
	OMA1	OMA1 zinc metallopeptidase. (527 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2725 aa)
	CARD8	Caspase recruitment domain family member 8. (393 aa)
	GAS2	Growth arrest specific 2. (314 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (479 aa)
	EPPK1	Epiplakin 1. (3436 aa)
	H1-4	Histone cluster 1 H1 family member e. (218 aa)
	BNIP5	BCL2 interacting protein 5. (625 aa)
	GSN	Gelsolin. (815 aa)
	CASP6	Caspase 6; Belongs to the phospholipase A2 family. (431 aa)
	H1-8	H1 histone family member O oocyte specific. (343 aa)
	LOC105261012	Uncharacterized protein. (427 aa)
	LMNTD1	Lamin tail domain containing 1. (497 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (718 aa)
	LMNTD2	Lamin tail domain containing 2. (674 aa)
	BMF	Bcl2 modifying factor. (287 aa)
	TNFSF10	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
	KPNA1	Importin subunit alpha; Functions in nuclear protein import. (564 aa)
	STK24	Serine/threonine kinase 24. (470 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	LOC101084636	DUF4203 domain-containing protein. (350 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	DAPK2	Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACIN1	CASP3	ENSFCAP00000002152	ENSFCAP00000031946	Apoptotic chromatin condensation inducer 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.792
ACIN1	CASP7	ENSFCAP00000002152	ENSFCAP00000057656	Apoptotic chromatin condensation inducer 1.	Caspase 7; Belongs to the peptidase C14A family.	0.434
ACIN1	DFFB	ENSFCAP00000002152	ENSFCAP00000010799	Apoptotic chromatin condensation inducer 1.	DNA fragmentation factor subunit beta.	0.438
ADD1	APAF1	ENSFCAP00000024528	ENSFCAP00000047198	Adducin 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.559
ADD1	CASP3	ENSFCAP00000024528	ENSFCAP00000031946	Adducin 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.756
APAF1	ADD1	ENSFCAP00000047198	ENSFCAP00000024528	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Adducin 1.	0.559
APAF1	APIP	ENSFCAP00000047198	ENSFCAP00000002355	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	0.807
APAF1	AVEN	ENSFCAP00000047198	ENSFCAP00000056161	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis and caspase activation inhibitor.	0.898
APAF1	BAK1	ENSFCAP00000047198	ENSFCAP00000059499	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.737
APAF1	BAX	ENSFCAP00000047198	ENSFCAP00000000237	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.626
APAF1	BCL2	ENSFCAP00000047198	ENSFCAP00000062072	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.918
APAF1	BCL2L1	ENSFCAP00000047198	ENSFCAP00000059067	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.712
APAF1	BCL2L10	ENSFCAP00000047198	ENSFCAP00000042499	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.582
APAF1	BCL2L11	ENSFCAP00000047198	ENSFCAP00000049779	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.419
APAF1	BCL2L2	ENSFCAP00000047198	ENSFCAP00000045084	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 2.	0.627
APAF1	BID	ENSFCAP00000047198	ENSFCAP00000055705	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.540
APAF1	BNIP5	ENSFCAP00000047198	ENSFCAP00000054015	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 interacting protein 5.	0.582
APAF1	BOK	ENSFCAP00000047198	ENSFCAP00000057223	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.582
APAF1	CARD8	ENSFCAP00000047198	ENSFCAP00000029752	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain family member 8.	0.737
APAF1	CASP3	ENSFCAP00000047198	ENSFCAP00000031946	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.995