STRINGSTRING
SRC SRC ERAS ERAS DIAPH1 DIAPH1 EGF EGF AKT2 AKT2 ENSFCAP00000052091 ENSFCAP00000052091 NRG2 NRG2 ENSFCAP00000048998 ENSFCAP00000048998 YES1 YES1 USP8 USP8 PTPN18 PTPN18 ERBIN ERBIN NRG1 NRG1 ERBB4 ERBB4 EGFR EGFR RNF41 RNF41 GAB1 GAB1 PIK3CA PIK3CA NRG3 NRG3 PRKCE PRKCE NRAS NRAS BTC BTC LOC109502223 LOC109502223 ENSFCAP00000031119 ENSFCAP00000031119 PTK6 PTK6 FNDC3B FNDC3B ENSFCAP00000026617 ENSFCAP00000026617 GRB2 GRB2 SOS1 SOS1 ERBB2 ERBB2 CSDE1 CSDE1 FYN FYN FNDC3A FNDC3A MATK MATK RPS27A RPS27A EREG EREG KRAS KRAS ERBB3 ERBB3 CUL5 CUL5 PRKCA PRKCA PIK3R1 PIK3R1 GRB7 GRB7 UBA52 UBA52 CDC37 CDC37 SRMS SRMS STUB1 STUB1 PTPN12 PTPN12 AKT1 AKT1 AKT3 AKT3 HRAS HRAS MEMO1 MEMO1 SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (678 aa)
ERASES cell expressed Ras. (233 aa)
DIAPH1Diaphanous related formin 1. (1290 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ENSFCAP00000052091Uncharacterized protein. (1125 aa)
NRG2Neuregulin 2. (862 aa)
ENSFCAP00000048998CDC37_N domain-containing protein. (55 aa)
YES1Tyrosine-protein kinase. (546 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
PTPN18Uncharacterized protein. (94 aa)
ERBINErbb2 interacting protein. (1461 aa)
NRG1Neuregulin 1. (713 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RNF41Ring finger protein 41. (317 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRG3Neuregulin 3. (720 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BTCBetacellulin. (194 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ENSFCAP00000031119Uncharacterized protein. (383 aa)
PTK6Tyrosine-protein kinase. (450 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ERBB2Receptor protein-tyrosine kinase. (1308 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FYNTyrosine-protein kinase. (589 aa)
FNDC3AFibronectin type III domain containing 3A. (1199 aa)
MATKTyrosine-protein kinase. (838 aa)
RPS27ARibosomal protein S27a. (156 aa)
EREGEpiregulin. (169 aa)
KRASUncharacterized protein. (380 aa)
ERBB3ERBB3. (1339 aa)
CUL5Cullin-5; Belongs to the cullin family. (780 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GRB7Growth factor receptor bound protein 7. (530 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
CDC37Uncharacterized protein. (377 aa)
SRMSTyrosine-protein kinase. (507 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
PTPN12Protein tyrosine phosphatase non-receptor type 12. (782 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MEMO1Mediator of cell motility 1. (297 aa)
SHC1SHC adaptor protein 1. (566 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.