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RPS6KA1 RPS6KA1 MAPK3 MAPK3 ENSFCAP00000034335 ENSFCAP00000034335 ENSFCAP00000034079 ENSFCAP00000034079 LOC109502223 LOC109502223 CREB5 CREB5 LOC101099075 LOC101099075 RPS6KA3 RPS6KA3 TNIP2 TNIP2 ENSFCAP00000026617 ENSFCAP00000026617 KHNYN KHNYN MAPK1 MAPK1 N4BP1 N4BP1 DUSP6 DUSP6 LRRC71 LRRC71 MAPK14 MAPK14 DUSP4 DUSP4 ATF2 ATF2 TAB3 TAB3 JUN JUN IKBKG IKBKG PPP2CB PPP2CB RPS27A RPS27A NLRP6 NLRP6 MAP3K7 MAP3K7 RIPK2 RIPK2 LOC101092674 LOC101092674 MAP2K6 MAP2K6 LRRC14 LRRC14 TONSL TONSL SAA1 SAA1 S100A12 S100A12 RELCH RELCH FNBP4 FNBP4 MAPKAPK2 MAPKAPK2 ATF7 ATF7 CCDC71L CCDC71L CASP8 CASP8 TMEM189 TMEM189 USP14 USP14 PPP2R1B PPP2R1B NFKBIB NFKBIB NLRC5 NLRC5 MAPK10 MAPK10 NLRP9 NLRP9 RPS6KA5 RPS6KA5 APP APP NFKB2 NFKB2 RPS6KA4 RPS6KA4 TRAF2 TRAF2 ATF1 ATF1 LOC105260043 LOC105260043 VRK3 VRK3 VWC2 VWC2 DUSP3 DUSP3 RELA RELA TRAF6 TRAF6 MAPK9 MAPK9 MAP2K7 MAP2K7 MAP3K20 MAP3K20 IRF7 IRF7 FOS FOS NKIRAS2 NKIRAS2 IKBKB IKBKB RPS6KA2 RPS6KA2 LOC101099498 LOC101099498 FOSL2 FOSL2 MAPK8 MAPK8 PPP2CA PPP2CA NOD1 NOD1 CHUK CHUK MAPK15 MAPK15 MAP2K3 MAP2K3 USP18 USP18 LRRC74A LRRC74A ELK1 ELK1 HMGB1 HMGB1 LRRC34 LRRC34 PPP2R1A PPP2R1A NKIRAS1 NKIRAS1 TIFA TIFA KXD1 KXD1 NLRX1 NLRX1 S100B S100B PPP2R5D PPP2R5D MAP2K4 MAP2K4 TAB1 TAB1 MAPK11 MAPK11 LRRC45 LRRC45 TAB2 TAB2 IRAK2 IRAK2 IRAK1 IRAK1 ALPK1 ALPK1 PPP4R4 PPP4R4 UBA52 UBA52 DUSP7 DUSP7 MAPK7 MAPK7 NOD2 NOD2 CREB1 CREB1 NFKB1 NFKB1 MAPKAPK3 MAPKAPK3 NFKBIA NFKBIA IRF3 IRF3 AGER AGER LRRC31 LRRC31 UBE2N UBE2N PPP4R1 PPP4R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSFCAP00000034335UBIQUITIN_CONJUGAT_2 domain-containing protein. (104 aa)
ENSFCAP00000034079UBIQUITIN_CONJUGAT_2 domain-containing protein. (108 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
LOC101099075Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
TNIP2TNFAIP3 interacting protein 2. (436 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
KHNYNKH and NYN domain containing. (677 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LRRC71Leucine rich repeat containing 71. (556 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
RPS27ARibosomal protein S27a. (156 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
LOC101092674WRNPLPNID domain-containing protein. (951 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LRRC14Leucine rich repeat containing 14. (503 aa)
TONSLTonsoku like, DNA repair protein. (1370 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (163 aa)
S100A12EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1222 aa)
FNBP4Formin binding protein 4. (1020 aa)
MAPKAPK2MAPK activated protein kinase 2. (409 aa)
ATF7Uncharacterized protein. (511 aa)
CCDC71LCoiled-coil domain containing 71 like. (238 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
TMEM189Transmembrane protein 189. (296 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
NLRC5NLR family CARD domain containing 5. (1844 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NLRP9NLR family pyrin domain containing 9. (990 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
NFKB2Nuclear factor kappa B subunit 2. (921 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
ATF1Activating transcription factor 1. (279 aa)
LOC105260043Uncharacterized protein. (391 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
VWC2Von Willebrand factor C domain containing 2. (333 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAP3K20Uncharacterized protein. (800 aa)
IRF7Interferon regulatory factor 7. (512 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
NKIRAS2Uncharacterized protein. (41 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
RPS6KA2Ribosomal protein S6 kinase. (741 aa)
LOC101099498Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
MAPK15Mitogen-activated protein kinase. (550 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa)
USP18Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (403 aa)
LRRC74ALeucine rich repeat containing 74A. (505 aa)
ELK1ETS transcription factor ELK1. (487 aa)
HMGB1Uncharacterized protein. (233 aa)
LRRC34Leucine rich repeat containing 34. (513 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (289 aa)
TIFAFHA domain-containing protein. (381 aa)
KXD1KxDL motif containing 1. (201 aa)
NLRX1NLR family member X1. (975 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (618 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
ALPK1Alpha kinase 1. (1239 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (874 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IRF3Interferon regulatory factor 3. (420 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
LRRC31Leucine rich repeat containing 31. (566 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (949 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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