STRINGSTRING
SNW1 SNW1 ITGA8 ITGA8 TFDP2 TFDP2 UBE2M UBE2M CCNQ CCNQ MKX MKX TGIF2LX TGIF2LX TGFB1 TGFB1 NEDD8 NEDD8 PARP1 PARP1 LTBP2 LTBP2 ITGB8 ITGB8 STUB1 STUB1 E2F4 E2F4 PARD6A PARD6A UBA52 UBA52 TGFB3 TGFB3 SMURF1 SMURF1 FBN1 FBN1 SP1 SP1 JUNB JUNB RBL1 RBL1 CBL CBL RPS27A RPS27A IRX4 IRX4 SMURF2 SMURF2 SKI SKI ITGB6 ITGB6 TGIF2 TGIF2 LDLRAD4 LDLRAD4 TGIF1 TGIF1 NCOR2 NCOR2 ZFYVE9 ZFYVE9 MAPK1 MAPK1 ENSFCAP00000026617 ENSFCAP00000026617 USP9X USP9X CDK9 CDK9 IRX6 IRX6 RNF111 RNF111 SMAD4 SMAD4 FKBP1A FKBP1A MEIS3 MEIS3 IRX3 IRX3 ITGB1 ITGB1 CCNC CCNC TGFB2 TGFB2 LOC109502223 LOC109502223 HDAC1 HDAC1 NCOR1 NCOR1 ITGB3 ITGB3 ITGB5 ITGB5 SMAD3 SMAD3 MAPK3 MAPK3 MTMR4 MTMR4 WWTR1 WWTR1 LTBP4 LTBP4 SKIL SKIL KXD1 KXD1 CDK19 CDK19 CCNK CCNK LTBP1 LTBP1 PMEPA1 PMEPA1 TRIM33 TRIM33 BAMBI BAMBI SMAD7 SMAD7 F11R F11R IRX5 IRX5 IRX2 IRX2 ATP1B4 ATP1B4 ARHGEF18 ARHGEF18 TGFBR1 TGFBR1 CDK8 CDK8 CCNT1 CCNT1 IRX1 IRX1 TFDP1 TFDP1 PCSK4 PCSK4 PARD3B PARD3B MEN1 MEN1 LTBP3 LTBP3 PPM1A PPM1A ITGAV ITGAV STRAP STRAP UBE2D1 UBE2D1 PARD3 PARD3 NEDD4L NEDD4L PRKCZ PRKCZ CCNT2 CCNT2 CGN CGN SMAD2 SMAD2 TGFBR2 TGFBR2 FURIN FURIN CA13 CA13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNW1SNW domain containing 1. (570 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
TFDP2Transcription factor. (386 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
CCNQCyclin Q; Belongs to the cyclin family. (376 aa)
MKXMohawk homeobox. (454 aa)
TGIF2LXHomeobox domain-containing protein. (231 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1823 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
E2F4E2F transcription factor 4. (406 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
FBN1Fibrillin 1. (2871 aa)
SP1Sp1 transcription factor. (786 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
CBLCbl proto-oncogene. (902 aa)
RPS27ARibosomal protein S27a. (156 aa)
IRX4Iroquois homeobox 4. (520 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
SKISKI proto-oncogene. (730 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
NCOR2Nuclear receptor corepressor 2. (2458 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (492 aa)
IRX6Iroquois homeobox 6. (451 aa)
RNF111Ring finger protein 111. (1002 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
MEIS3Homeobox domain-containing protein. (377 aa)
IRX3Iroquois homeobox 3. (502 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MTMR4Myotubularin related protein 4. (1209 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1656 aa)
SKILSKI like proto-oncogene. (686 aa)
KXD1KxDL motif containing 1. (201 aa)
CDK19Cyclin dependent kinase 19. (502 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1717 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (331 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
F11RJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...] (378 aa)
IRX5Iroquois homeobox 5. (483 aa)
IRX2Iroquois homeobox 2. (456 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
ARHGEF18Uncharacterized protein. (1357 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
CCNT1CYCLIN domain-containing protein; Belongs to the cyclin family. (184 aa)
IRX1Iroquois homeobox 1. (485 aa)
TFDP1Transcription factor. (423 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (825 aa)
PARD3BPar-3 family cell polarity regulator beta. (1202 aa)
MEN1Menin 1. (749 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1302 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (486 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
STRAPWD_REPEATS_REGION domain-containing protein. (350 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
PARD3Par-3 family cell polarity regulator. (1417 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1246 aa)
PRKCZProtein kinase C zeta. (649 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (742 aa)
CGNCingulin. (1208 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (877 aa)
CA13Carbonic anhydrase 13. (534 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (16%) [HD]