STRINGSTRING
MAPK12 MAPK12 ARVCF ARVCF ITGB3 ITGB3 PTK2 PTK2 NRAS NRAS AXL AXL CEP170 CEP170 PXN PXN TRIB3 TRIB3 ROCK1 ROCK1 PIK3CA PIK3CA SHE SHE NCK1 NCK1 MAPKAP1 MAPKAP1 PRKACB PRKACB RASA1 RASA1 SRC SRC STX7 STX7 CTNND1 CTNND1 NCKAP1L NCKAP1L PIK3R2 PIK3R2 BAIAP2 BAIAP2 PRR5 PRR5 SHD SHD CRK CRK TENM4 TENM4 PGF PGF CDH5 CDH5 VAV3 VAV3 SHB SHB PAK3 PAK3 BCAR1 BCAR1 NRP2 NRP2 ELMO3 ELMO3 RICTOR RICTOR VEGFA VEGFA CALM1 CALM1 ITGAV ITGAV ENSFCAP00000052091 ENSFCAP00000052091 CYFIP2 CYFIP2 ENSFCAP00000054708 ENSFCAP00000054708 PRKCZ PRKCZ PLCG1 PLCG1 CALM3 CALM3 LPXN LPXN ROCK2 ROCK2 AKT2 AKT2 NCF1 NCF1 ENSFCAP00000060347 ENSFCAP00000060347 MAPK13 MAPK13 PAK1 PAK1 ELMO1 ELMO1 CDC42 CDC42 AKT1 AKT1 VAV1 VAV1 SPHK1 SPHK1 PRKCD PRKCD AKT3 AKT3 CTNNB1 CTNNB1 THEM4 THEM4 HRAS HRAS NCK2 NCK2 PDPK1 PDPK1 FLT4 FLT4 MTOR MTOR VEGFB VEGFB NRP1 NRP1 SH2D2A SH2D2A CYBA CYBA ACTG1 ACTG1 NEDD9 NEDD9 MAPKAPK3 MAPKAPK3 SHF SHF WASF2 WASF2 VEGFC VEGFC TENM1 TENM1 SRMS SRMS TGFB1I1 TGFB1I1 HSH2D HSH2D WASF3 WASF3 KDR KDR ACTL8 ACTL8 PIK3R1 PIK3R1 PRKCB PRKCB BRK1 BRK1 VAV2 VAV2 MAPK11 MAPK11 PRKCA PRKCA ABI2 ABI2 CYFIP1 CYFIP1 NOS3 NOS3 MAPKAPK2 MAPKAPK2 CDH5-2 CDH5-2 SHC2 SHC2 NCF4 NCF4 KRAS KRAS WASF1 WASF1 ACTB ACTB ERAS ERAS CALM2 CALM2 M3WQU5_FELCA M3WQU5_FELCA PAK2 PAK2 PRKACA PRKACA HSPB1 HSPB1 PTK2B PTK2B ABI1 ABI1 NCF2 NCF2 FNDC3A FNDC3A FYN FYN CSDE1 CSDE1 EFS EFS TENM3 TENM3 STX12 STX12 LOC101100956 LOC101100956 MAPK14 MAPK14 CDC42-2 CDC42-2 TENM2 TENM2 MLST8 MLST8 PIK3CB PIK3CB FLT1 FLT1 CALML3 CALML3 NCKAP1 NCKAP1 CASS4 CASS4 FNDC3B FNDC3B LOC101097703 LOC101097703 ENSFCAP00000029012 ENSFCAP00000029012 CAV1 CAV1 PTK6 PTK6 JUP JUP ELMO2 ELMO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (367 aa)
ARVCFARVCF delta catenin family member. (965 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
CEP170Centrosomal protein 170. (1588 aa)
PXNPaxillin. (1089 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHESrc homology 2 domain containing E. (460 aa)
NCK1Cytoplasmic protein. (455 aa)
MAPKAP1MAPK associated protein 1. (575 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
RASA1RAS p21 protein activator 1. (1039 aa)
SRCTyrosine-protein kinase. (678 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
CTNND1Catenin delta 1. (962 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
BAIAP2BAI1 associated protein 2. (548 aa)
PRR5Proline rich 5. (389 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
TENM4Teneurin transmembrane protein 4. (2823 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CDH5Uncharacterized protein. (402 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
SHBSH2 domain-containing protein. (508 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (889 aa)
NRP2Neuropilin 2. (992 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSFCAP00000052091Uncharacterized protein. (1125 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1335 aa)
ENSFCAP00000054708Uncharacterized protein. (102 aa)
PRKCZProtein kinase C zeta. (649 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
MAPK13Mitogen-activated protein kinase. (402 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ELMO1Engulfment and cell motility 1. (742 aa)
CDC42Uncharacterized protein. (191 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
SPHK1Sphingosine kinase 1. (473 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CTNNB1Catenin beta 1. (783 aa)
THEM4Thioesterase superfamily member 4. (238 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NCK2Cytoplasmic protein. (380 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SH2D2ASH2 domain containing 2A. (383 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ACTG1Actin gamma 1. (375 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
SHFSrc homology 2 domain containing F. (489 aa)
WASF2WASP family member 2. (498 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
SRMSTyrosine-protein kinase. (507 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
HSH2DHematopoietic SH2 domain containing. (383 aa)
WASF3WASP family member 3. (502 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ABI2Abl interactor 2. (542 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
MAPKAPK2MAPK activated protein kinase 2. (409 aa)
CDH5-2Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
SHC2SHC adaptor protein 2. (583 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
KRASUncharacterized protein. (380 aa)
WASF1WASP family member 1. (570 aa)
ACTBActin beta. (389 aa)
ERASES cell expressed Ras. (233 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
ABI1Abl interactor 1. (508 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
FNDC3AFibronectin type III domain containing 3A. (1199 aa)
FYNTyrosine-protein kinase. (589 aa)
CSDE1Cold shock domain containing E1. (844 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
TENM3Teneurin transmembrane protein 3. (2699 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
LOC101100956Uncharacterized protein. (129 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CDC42-2Uncharacterized protein. (191 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NCKAP1NCK associated protein 1. (1134 aa)
CASS4Cas scaffold protein family member 4. (818 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PTK6Tyrosine-protein kinase. (450 aa)
JUPUncharacterized protein. (744 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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