STRINGSTRING
AKT1S1 AKT1S1 CHUK CHUK MKRN3 MKRN3 AKT2 AKT2 CEP170 CEP170 TSC2 TSC2 CDKN1A CDKN1A MKRN1 MKRN1 CASP9 CASP9 RNF141 RNF141 MKRN2 MKRN2 AKT1 AKT1 AKT3 AKT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1S1AKT1 substrate 1. (276 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
MKRN3Makorin ring finger protein 3. (433 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
CEP170Centrosomal protein 170. (1588 aa)
TSC2TSC complex subunit 2. (1806 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MKRN1Makorin ring finger protein 1. (482 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
RNF141Ring finger protein 141. (230 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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