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| | AREG | Amphiregulin. (323 aa) |
| | PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1. (843 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (435 aa) |
| | ICOS | Inducible T cell costimulator. (247 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | KITLG | Soluble KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). (274 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | CD86 | B-lymphocyte activation antigen B7-2 (CD86). (332 aa) |
| | PPP2R5A | Protein phosphatase 2 regulatory subunit B'alpha. (642 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (779 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (772 aa) |
| | RAC2 | Rac family small GTPase 2. (234 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | ENSFCAP00000054708 | Uncharacterized protein. (102 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa) |
| | RAC3 | Rac family small GTPase 3. (205 aa) |
| | ENSFCAP00000052091 | Uncharacterized protein. (1125 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | NRG2 | Neuregulin 2. (862 aa) |
| | STRN | Striatin. (780 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa) |
| | INSC | INSC spindle orientation adaptor protein. (579 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | IRS2 | Insulin receptor substrate 2. (1335 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa) |
| | NRG1 | Neuregulin 1. (713 aa) |
| | FGF5 | Fibroblast growth factor 5. (279 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (818 aa) |
| | TRAT1 | T cell receptor associated transmembrane adaptor 1. (195 aa) |
| | ENSFCAP00000044386 | Uncharacterized protein. (156 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (548 aa) |
| | ESR2 | Estrogen receptor 2. (574 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1308 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | TGFA | Transforming growth factor alpha. (192 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1. (1690 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (543 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | GAB1 | GRB2 associated binding protein 1. (751 aa) |
| | CD276 | CD276 molecule. (669 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NRG3 | Neuregulin 3. (720 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (357 aa) |
| | CEP170 | Centrosomal protein 170. (1588 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa) |
| | BTC | Betacellulin. (194 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (852 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (421 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1381 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | PTK6 | Tyrosine-protein kinase. (450 aa) |
| | FNDC3B | Fibronectin type III domain containing 3B. (1207 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | KLB | Klotho beta. (1026 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | FAM102B | Family with sequence similarity 102 member B. (360 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1308 aa) |
| | FLT3LG | Fms related tyrosine kinase 3 ligand. (291 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | LOC101100432 | Uncharacterized protein. (514 aa) |
| | IER3 | Immediate early response 3. (156 aa) |
| | LOC101082222 | Uncharacterized protein. (570 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | LRRC40 | Leucine rich repeat containing 40. (605 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | FYN | Tyrosine-protein kinase. (589 aa) |
| | FNDC3A | Fibronectin type III domain containing 3A. (1199 aa) |
| | SPEM1 | Spermatid maturation 1. (300 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | EREG | Epiregulin. (169 aa) |
| | IRS1 | Insulin receptor substrate 1. (1234 aa) |
| | M3WUK9_FELCA | Uncharacterized protein. (166 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (556 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | LOC101092674 | WRNPLPNID domain-containing protein. (951 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (639 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (830 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | ERBB3 | ERBB3. (1339 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa) |
| | KL | Klotho. (1014 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1222 aa) |
| | FNBP4 | Formin binding protein 4. (1020 aa) |
| | STRN3 | Striatin 3. (795 aa) |
| | WDR64 | WD repeat domain 64. (1089 aa) |
| | SPEM2 | SPEM family member 2. (497 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (606 aa) |
| | PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2. (1349 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (874 aa) |
| | CD80 | B-lymphocyte activation antigen B7-1 (CD80). (292 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | IL33 | Interleukin 33. (268 aa) |
| | SRMS | Tyrosine-protein kinase. (507 aa) |
| | GAB2 | GRB2 associated binding protein 2. (678 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (550 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (846 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (949 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (606 aa) |
| | RHOG | Ras homolog family member G. (191 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa) |
| | THEM4 | Thioesterase superfamily member 4. (238 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa) |
| | CD19 | CD19 molecule. (641 aa) |
| | FAM102A | Family with sequence similarity 102 member A. (384 aa) |
| | PIP5KL1 | Phosphatidylinositol-4-phosphate 5-kinase like 1. (396 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (305 aa) |
| | STRN4 | Striatin 4. (817 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
