STRINGSTRING
ITGA8 ITGA8 UBE2M UBE2M TGFB1 TGFB1 NEDD8 NEDD8 LTBP2 LTBP2 ITGB8 ITGB8 STUB1 STUB1 UBA52 UBA52 TGFB3 TGFB3 FBN1 FBN1 CBL CBL RPS27A RPS27A SMURF2 SMURF2 ITGB6 ITGB6 LDLRAD4 LDLRAD4 ZFYVE9 ZFYVE9 ENSFCAP00000026617 ENSFCAP00000026617 SMAD4 SMAD4 FKBP1A FKBP1A ITGB1 ITGB1 TGFB2 TGFB2 LOC109502223 LOC109502223 ITGB3 ITGB3 ITGB5 ITGB5 SMAD3 SMAD3 MTMR4 MTMR4 LTBP4 LTBP4 KXD1 KXD1 LTBP1 LTBP1 PMEPA1 PMEPA1 BAMBI BAMBI SMAD7 SMAD7 TGFBR1 TGFBR1 PCSK4 PCSK4 LTBP3 LTBP3 ITGAV ITGAV STRAP STRAP SMAD2 SMAD2 TGFBR2 TGFBR2 FURIN FURIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1823 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FBN1Fibrillin 1. (2871 aa)
CBLCbl proto-oncogene. (902 aa)
RPS27ARibosomal protein S27a. (156 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
MTMR4Myotubularin related protein 4. (1209 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1656 aa)
KXD1KxDL motif containing 1. (201 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1717 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (331 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (825 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1302 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
STRAPWD_REPEATS_REGION domain-containing protein. (350 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (877 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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