STRINGSTRING
SMURF1 SMURF1 TGFB1 TGFB1 PARD6A PARD6A UBA52 UBA52 RPS27A RPS27A ENSFCAP00000026617 ENSFCAP00000026617 LOC109502223 LOC109502223 F11R F11R ARHGEF18 ARHGEF18 TGFBR1 TGFBR1 PARD3B PARD3B PARD3 PARD3 PRKCZ PRKCZ CGN CGN TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPS27ARibosomal protein S27a. (156 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
F11RJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...] (378 aa)
ARHGEF18Uncharacterized protein. (1357 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PARD3BPar-3 family cell polarity regulator beta. (1202 aa)
PARD3Par-3 family cell polarity regulator. (1417 aa)
PRKCZProtein kinase C zeta. (649 aa)
CGNCingulin. (1208 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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