STRINGSTRING
PDE6C PDE6C PDE6G PDE6G DEPDC1 DEPDC1 OPN1LW OPN1LW SAG SAG TTR TTR GPC2 GPC2 CAMKMT CAMKMT GRK7 GRK7 RDH8 RDH8 CNGA1 CNGA1 PDE6B PDE6B APOM APOM GNAT1 GNAT1 GRK1 GRK1 GPC4 GPC4 LRP10 LRP10 PPEF2 PPEF2 BCO2 BCO2 LRP2 LRP2 NMT1 NMT1 RRH RRH SDC1 SDC1 PLB1 PLB1 METAP1 METAP1 BCO1 BCO1 RETSAT RETSAT CNGB1 CNGB1 RGR RGR CYP4V2 CYP4V2 RBP2 RBP2 OPN1SW OPN1SW HSD17B6 HSD17B6 DHRS3 DHRS3 RHO RHO MYO7B MYO7B GUCA1A GUCA1A RDH5 RDH5 RDH16 RDH16 PTCHD4 PTCHD4 RGS9 RGS9 ABCA4 ABCA4 APOC2 APOC2 GUCY2D GUCY2D APOA1 APOA1 PTCHD1 PTCHD1 CALM2 CALM2 M3WQU5_FELCA M3WQU5_FELCA FNTA FNTA APOC3 APOC3 LOC101099582 LOC101099582 LRP1B LRP1B PLEKHD1 PLEKHD1 GNGT1 GNGT1 RDH10 RDH10 NMT2 NMT2 RCVRN RCVRN GPC6 GPC6 SDC4 SDC4 LRP1 LRP1 LRAT LRAT APOB APOB FNTB FNTB GUCY2F GUCY2F MYO7A MYO7A PPEF1 PPEF1 CALML3 CALML3 GPC1 GPC1 CNGB3 CNGB3 LOC101097703 LOC101097703 ENSFCAP00000029012 ENSFCAP00000029012 GPC5 GPC5 SDR9C7 SDR9C7 RBP1 RBP1 CHURC1 CHURC1 DHRS9 DHRS9 OPN3 OPN3 SDC3 SDC3 AWAT2 AWAT2 METAP2 METAP2 RBP3 RBP3 STRA6 STRA6 VEZT VEZT GPC3 GPC3 LRP8 LRP8 PDE6A PDE6A LRP12 LRP12 GUCA1B GUCA1B OPN5 OPN5 RBP4 RBP4 CLPS CLPS RGS9BP RGS9BP CALM1 CALM1 GPIHBP1 GPIHBP1 NAPEPLD NAPEPLD SMPDL3A SMPDL3A LPL LPL AGRN AGRN GUCA1C GUCA1C CALM3 CALM3 RPE65 RPE65 AKR1C3 AKR1C3 SDC2 SDC2 PNLIPRP1 PNLIPRP1 LRP3 LRP3 APOA4 APOA4 LOC101088073 LOC101088073 RLBP1 RLBP1 RDH12 RDH12 PDE6H PDE6H ENSFCAP00000059452 ENSFCAP00000059452 GNB5 GNB5 ENSFCAP00000060347 ENSFCAP00000060347 ENSFCAP00000060547 ENSFCAP00000060547 PYROXD2 PYROXD2 RDH11 RDH11 HSPG2 HSPG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE6CPhosphodiesterase. (846 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones (By similarity). (87 aa)
DEPDC1DEP domain containing 1. (811 aa)
OPN1LWLong-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (364 aa)
SAGS-antigen visual arrestin. (407 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (146 aa)
GPC2Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (610 aa)
CAMKMTCalmodulin-lysine N-methyltransferase. (323 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (695 aa)
PDE6BPhosphodiesterase. (880 aa)
APOMApolipoprotein M. (188 aa)
GNAT1G protein subunit alpha transducin 1. (350 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (564 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
LRP10LDL receptor related protein 10. (712 aa)
PPEF2Serine/threonine-protein phosphatase with EF-hands. (752 aa)
BCO2Beta-carotene oxygenase 2. (575 aa)
LRP2LDL receptor related protein 2. (4646 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (539 aa)
RRHRetinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (337 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
PLB1Phospholipase B1. (1458 aa)
METAP1Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (386 aa)
BCO1Beta-carotene oxygenase 1. (546 aa)
RETSATRetinol saturase. (610 aa)
CNGB1Cyclic nucleotide-binding domain-containing protein. (1204 aa)
RGRRetinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
RBP2Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (142 aa)
OPN1SWOpsin 1, short wave sensitive. (349 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
MYO7BMyosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2137 aa)
GUCA1AGuanylate cyclase activator 1A. (275 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa)
PTCHD4Patched domain containing 4. (843 aa)
RGS9Regulator of G protein signaling 9. (668 aa)
ABCA4ATP binding cassette subfamily A member 4. (2267 aa)
APOC2Uncharacterized protein. (161 aa)
GUCY2DGuanylate cyclase. (1100 aa)
APOA1Apolipoprotein A1. (295 aa)
PTCHD1Patched domain containing 1. (888 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (452 aa)
APOC3Apolipoprotein C3. (116 aa)
LOC101099582Guanylate cyclase. (1118 aa)
LRP1BLDL receptor related protein 1B. (4599 aa)
PLEKHD1Pleckstrin homology and coiled-coil domain containing D1. (506 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
NMT2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (530 aa)
RCVRNRecoverin. (338 aa)
GPC6Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
SDC4Syndecan 4. (201 aa)
LRP1LDL receptor related protein 1. (4561 aa)
LRATLecithin retinol acyltransferase. (484 aa)
APOBApolipoprotein B. (4441 aa)
FNTBProtein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (437 aa)
GUCY2FGuanylate cyclase. (1108 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
PPEF1Serine/threonine-protein phosphatase with EF-hands. (660 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (807 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (570 aa)
SDR9C7Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
CHURC1Churchill domain containing 1. (112 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (665 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (341 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (478 aa)
RBP3Retinol binding protein 3. (1258 aa)
STRA6Stimulated by retinoic acid 6. (700 aa)
VEZTVezatin, adherens junctions transmembrane protein. (785 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
LRP8LDL receptor related protein 8. (1015 aa)
PDE6APhosphodiesterase. (861 aa)
LRP12LDL receptor related protein 12. (1008 aa)
GUCA1BGuanylate cyclase activator 1B. (201 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (376 aa)
RBP4Retinol binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. (372 aa)
CLPSColipase. (112 aa)
RGS9BPRegulator of G protein signaling 9 binding protein. (235 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (178 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (394 aa)
SMPDL3ASphingomyelin phosphodiesterase acid like 3A. (506 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity). (482 aa)
AGRNAgrin. (2135 aa)
GUCA1CGuanylate cyclase activator 1C. (210 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
RPE65Retinoid isomerohydrolase RPE65. (628 aa)
AKR1C3Aldo_ket_red domain-containing protein. (419 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (210 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (495 aa)
LRP3LDL receptor related protein 3. (1131 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (452 aa)
LOC101088073Uncharacterized protein. (2104 aa)
RLBP1Retinaldehyde binding protein 1. (322 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
PDE6HUncharacterized protein. (122 aa)
ENSFCAP00000059452Uncharacterized protein. (179 aa)
GNB5G protein subunit beta 5. (403 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
ENSFCAP00000060547SSD domain-containing protein. (425 aa)
PYROXD2Pyridine nucleotide-disulphide oxidoreductase domain 2. (585 aa)
RDH11Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (426 aa)
HSPG2Heparan sulfate proteoglycan 2. (4385 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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