STRINGSTRING
ITSN1 ITSN1 NCK2 NCK2 TIAM1 TIAM1 ARPC2 ARPC2 ARPC3 ARPC3 PAK1 PAK1 AP2A1 AP2A1 CDC42 CDC42 ACTG1 ACTG1 EPHA1 EPHA1 EPHA4 EPHA4 CFL2 CFL2 SRMS SRMS EPHB3 EPHB3 EPHA2 EPHA2 ACTL8 ACTL8 VAV2 VAV2 CFL1 CFL1 ACTR3 ACTR3 MMP9 MMP9 EPHB6 EPHB6 ARPC1A ARPC1A EFNB2 EFNB2 ARPC5 ARPC5 EPHA7 EPHA7 PAK2 PAK2 PSENEN PSENEN M3WS97_FELCA M3WS97_FELCA ARPC4 ARPC4 CLTCL1 CLTCL1 FNDC3A FNDC3A EPHA8 EPHA8 FYN FYN ARPC5L ARPC5L CLTC CLTC LYN LYN SDCBP SDCBP CDC42-2 CDC42-2 ARHGEF7 ARHGEF7 WASL WASL AP2A2 AP2A2 FNDC3B FNDC3B EFNB1 EFNB1 ACTB ACTB EFNA1 EFNA1 ROCK2 ROCK2 CLTA CLTA LIMK2 LIMK2 SDC2 SDC2 GRIN1 GRIN1 KALRN KALRN ELSPBP1 ELSPBP1 DNM1 DNM1 FMN2 FMN2 AP2M1 AP2M1 ACTR3B ACTR3B ENSFCAP00000052091 ENSFCAP00000052091 APH1B APH1B EFNA3 EFNA3 FMN1 FMN1 YES1 YES1 EPHA6 EPHA6 PSEN1 PSEN1 PAK3 PAK3 ENSFCAP00000047404 ENSFCAP00000047404 EFNA2 EFNA2 NCSTN NCSTN VAV3 VAV3 EFNB3 EFNB3 GRIN2B GRIN2B APH1A APH1A PSEN2 PSEN2 CLTB CLTB ENSFCAP00000043946 ENSFCAP00000043946 NGEF NGEF EFNA4 EFNA4 AP2B1 AP2B1 EPHB1 EPHB1 EFNA5 EFNA5 ENSFCAP00000041826 ENSFCAP00000041826 SRC SRC RASA1 RASA1 MMP2 MMP2 ENSFCAP00000039787 ENSFCAP00000039787 EPHB4 EPHB4 ROCK1 ROCK1 EPHA5 EPHA5 ENSFCAP00000035896 ENSFCAP00000035896 ACTR2 ACTR2 SDCBP2 SDCBP2 PTK2 PTK2 ENSFCAP00000032522 ENSFCAP00000032522 EPHB2 EPHB2 EPHA10 EPHA10 DSTN DSTN URB2 URB2 ARHGEF28 ARHGEF28 GIT1 GIT1 PTK6 PTK6 EPHA3 EPHA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITSN1Intersectin 1. (1721 aa)
NCK2Cytoplasmic protein. (380 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
CDC42Uncharacterized protein. (191 aa)
ACTG1Actin gamma 1. (375 aa)
EPHA1EPH receptor A1. (976 aa)
EPHA4EPH receptor A4. (986 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
SRMSTyrosine-protein kinase. (507 aa)
EPHB3EPH receptor B3. (1000 aa)
EPHA2EPH receptor A2. (936 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
EPHB6EPH receptor B6. (1012 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (397 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
EPHA7EPH receptor A7. (1000 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
M3WS97_FELCAArp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
FNDC3AFibronectin type III domain containing 3A. (1199 aa)
EPHA8EPH receptor A8. (1003 aa)
FYNTyrosine-protein kinase. (589 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
LYNTyrosine-protein kinase. (526 aa)
SDCBPSyndecan binding protein. (298 aa)
CDC42-2Uncharacterized protein. (191 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (921 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (976 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
EFNB1Ephrin B1. (427 aa)
ACTBActin beta. (389 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (357 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
LIMK2LIM domain kinase 2. (711 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (210 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
KALRNKalirin RhoGEF kinase. (2987 aa)
ELSPBP1Epididymal sperm binding protein 1. (222 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
FMN2Formin 2. (1793 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (522 aa)
ENSFCAP00000052091Uncharacterized protein. (1125 aa)
APH1BUncharacterized protein. (516 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa)
FMN1Formin 1. (1417 aa)
YES1Tyrosine-protein kinase. (546 aa)
EPHA6EPH receptor A6. (1169 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (455 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
ENSFCAP00000047404Uncharacterized protein. (56 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (263 aa)
NCSTNNicastrin. (709 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
EFNB3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (330 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (562 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
ENSFCAP00000043946Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (118 aa)
NGEFNeuronal guanine nucleotide exchange factor. (707 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (314 aa)
AP2B1AP complex subunit beta. (951 aa)
EPHB1EPH receptor B1. (984 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ENSFCAP00000041826Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
SRCTyrosine-protein kinase. (678 aa)
RASA1RAS p21 protein activator 1. (1039 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ENSFCAP00000039787Uncharacterized protein. (58 aa)
EPHB4EPH receptor B4. (987 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
EPHA5EPH receptor A5. (1043 aa)
ENSFCAP00000035896Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (140 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
SDCBP2Syndecan binding protein 2. (287 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
ENSFCAP00000032522Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (132 aa)
EPHB2EPH receptor B2. (899 aa)
EPHA10EPH receptor A10. (1008 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (171 aa)
URB2URB2 ribosome biogenesis homolog. (1521 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1706 aa)
GIT1GIT ArfGAP 1. (770 aa)
PTK6Tyrosine-protein kinase. (450 aa)
EPHA3EPH receptor A3. (984 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.