STRINGSTRING
TRAF2 TRAF2 PSMD6 PSMD6 PSMC2 PSMC2 PSMD8 PSMD8 PSMC4 PSMC4 NFKB2 NFKB2 PSMD5 PSMD5 APP APP PSMB4 PSMB4 NLRP9 NLRP9 STAT3 STAT3 PSMD13 PSMD13 GZMB GZMB NLRC5 NLRC5 PTPN21 PTPN21 NFKBIB NFKBIB PSMC5 PSMC5 UBE2N UBE2N LRRC31 LRRC31 AGER AGER PSME1 PSME1 IL1B IL1B NFKBIA NFKBIA NFKB1 NFKB1 SIGIRR SIGIRR PSMD2 PSMD2 IL1A IL1A PELI2 PELI2 IL33 IL33 UBA52 UBA52 ALPK1 ALPK1 IRAK1 IRAK1 IRAK2 IRAK2 TAB2 TAB2 PSMA1 PSMA1 LRRC45 LRRC45 TAB1 TAB1 IL1R2 IL1R2 IL1R1 IL1R1 PSMB10 PSMB10 LOC101099215 LOC101099215 S100A12 S100A12 TONSL TONSL LRRC14 LRRC14 PSMB7 PSMB7 SQSTM1 SQSTM1 PTPN23 PTPN23 MAP2K6 MAP2K6 IL1RAP IL1RAP IL18RAP IL18RAP PSMD9 PSMD9 PSMB11 PSMB11 IL1RL1 IL1RL1 MAP3K7 MAP3K7 PSMD7 PSMD7 PTPN14 PTPN14 PSMA6 PSMA6 NLRP6 NLRP6 RPS27A RPS27A IRAK4 IRAK4 IL1RL2 IL1RL2 IKBKG IKBKG LOC101083848 LOC101083848 PSMD12 PSMD12 PSMD10 PSMD10 TAB3 TAB3 RBX1 RBX1 PSMD11 PSMD11 PSMA2 PSMA2 CUL1 CUL1 LRRC71 LRRC71 N4BP1 N4BP1 PSMA8 PSMA8 LOC101083171 LOC101083171 IL36RN IL36RN KHNYN KHNYN ENSFCAP00000026617 ENSFCAP00000026617 PSMB6 PSMB6 ENSFCAP00000026978 ENSFCAP00000026978 PELI1 PELI1 IL18 IL18 TNIP2 TNIP2 MAP3K3 MAP3K3 LOC101099075 LOC101099075 IL18BP IL18BP LOC109502223 LOC109502223 PSMA5 PSMA5 ENSFCAP00000034079 ENSFCAP00000034079 SMAD3 SMAD3 ENSFCAP00000034335 ENSFCAP00000034335 PSMF1 PSMF1 IL13 IL13 PSMC1 PSMC1 S100B S100B MYD88 MYD88 ENSFCAP00000036869 ENSFCAP00000036869 NLRX1 NLRX1 KXD1 KXD1 IL18R1 IL18R1 IL1RAPL1 IL1RAPL1 LOC111556170 LOC111556170 BTRC BTRC IL1F10 IL1F10 LOC111556171 LOC111556171 ENSFCAP00000041674 ENSFCAP00000041674 LOC101099498 LOC101099498 PSMC3 PSMC3 PSMD14 PSMD14 IKBKB IKBKB TOLLIP TOLLIP PELI3 PELI3 NKIRAS2 NKIRAS2 MFSD1 MFSD1 MAP3K20 MAP3K20 PSMA4 PSMA4 TRAF6 TRAF6 PSME4 PSME4 RELA RELA LOC101082405 LOC101082405 PSMD4 PSMD4 PSMB5 PSMB5 VWC2 VWC2 LOC105260043 LOC105260043 IL1RN IL1RN PTPN5 PTPN5 SAA1 SAA1 CTSG CTSG PSMD1 PSMD1 TIFA TIFA PSME2 PSME2 PSME3 PSME3 PSMB1 PSMB1 ENSFCAP00000053469 ENSFCAP00000053469 CCDC71L CCDC71L TBK1 TBK1 PSMA3 PSMA3 CASP8 CASP8 ENSFCAP00000055272 ENSFCAP00000055272 IL36G IL36G PTPN20 PTPN20 TMEM189 TMEM189 USP14 USP14 PSMA7 PSMA7 NKIRAS1 NKIRAS1 LRRC34 LRRC34 HMGB1 HMGB1 LRRC74A LRRC74A GSDMD GSDMD PSMB2 PSMB2 PSMC6 PSMC6 USP18 USP18 PSMB3 PSMB3 SKP1 SKP1 CHUK CHUK IRAK3 IRAK3 PSMD3 PSMD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (478 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (355 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
NFKB2Nuclear factor kappa B subunit 2. (921 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
NLRP9NLR family pyrin domain containing 9. (990 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (255 aa)
NLRC5NLR family CARD domain containing 5. (1844 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1167 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LRRC31Leucine rich repeat containing 31. (566 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
PSME1Proteasome activator subunit 1. (249 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
SIGIRRSingle Ig and TIR domain containing. (410 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (464 aa)
IL33Interleukin 33. (268 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
ALPK1Alpha kinase 1. (1239 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (618 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
IL1R2Interleukin 1 receptor type 2. (418 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
PSMB10Proteasome subunit beta. (273 aa)
LOC101099215Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (292 aa)
S100A12EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa)
TONSLTonsoku like, DNA repair protein. (1370 aa)
LRRC14Leucine rich repeat containing 14. (503 aa)
PSMB7Proteasome subunit beta. (277 aa)
SQSTM1Sequestosome 1. (443 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1658 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IL1RAPInterleukin 1 receptor accessory protein. (639 aa)
IL18RAPInterleukin 18 receptor accessory protein. (586 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (284 aa)
PSMB11Proteasome subunit beta. (276 aa)
IL1RL1Interleukin 1 receptor like 1. (556 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
NLRP6NLR family pyrin domain containing 6. (878 aa)
RPS27ARibosomal protein S27a. (156 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
IL1RL2Interleukin 1 receptor like 2. (554 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
LOC101083848Proteasome subunit beta. (209 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
RBX1Ring-box 1. (108 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
LRRC71Leucine rich repeat containing 71. (556 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
LOC101083171Proteasome subunit beta. (276 aa)
IL36RNInterleukin-1. (196 aa)
KHNYNKH and NYN domain containing. (677 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSFCAP00000026978Uncharacterized protein. (111 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TNIP2TNFAIP3 interacting protein 2. (436 aa)
MAP3K3Uncharacterized protein. (626 aa)
LOC101099075Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
IL18BPInterleukin 18 binding protein. (183 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
ENSFCAP00000034079UBIQUITIN_CONJUGAT_2 domain-containing protein. (108 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
ENSFCAP00000034335UBIQUITIN_CONJUGAT_2 domain-containing protein. (104 aa)
PSMF1Proteasome inhibitor subunit 1. (341 aa)
IL13Interleukin 13. (144 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
ENSFCAP00000036869Proteasome subunit alpha type. (197 aa)
NLRX1NLR family member X1. (975 aa)
KXD1KxDL motif containing 1. (201 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
LOC111556170Proteasome subunit beta type-8. (276 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
IL1F10Interleukin-1. (152 aa)
LOC111556171Uncharacterized protein. (234 aa)
ENSFCAP00000041674AAA domain-containing protein; Belongs to the AAA ATPase family. (189 aa)
LOC101099498Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
TOLLIPToll interacting protein. (306 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
NKIRAS2Uncharacterized protein. (41 aa)
MFSD1Major facilitator superfamily domain containing 1. (468 aa)
MAP3K20Uncharacterized protein. (800 aa)
PSMA4Proteasome subunit alpha type. (277 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PSME4Proteasome activator subunit 4. (1865 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
LOC101082405AAA domain-containing protein. (330 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (423 aa)
PSMB5Proteasome subunit beta. (263 aa)
VWC2Von Willebrand factor C domain containing 2. (333 aa)
LOC105260043Uncharacterized protein. (391 aa)
IL1RNInterleukin-1. (182 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (593 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (163 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (292 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
TIFAFHA domain-containing protein. (381 aa)
PSME2Proteasome activator subunit 2. (253 aa)
PSME3Uncharacterized protein. (265 aa)
PSMB1Proteasome subunit beta. (261 aa)
ENSFCAP00000053469PA28_beta domain-containing protein. (192 aa)
CCDC71LCoiled-coil domain containing 71 like. (238 aa)
TBK1TANK binding kinase 1. (729 aa)
PSMA3Proteasome subunit alpha type. (258 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
ENSFCAP00000055272Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
IL36GInterleukin-1. (219 aa)
PTPN20Protein tyrosine phosphatase non-receptor type 20. (446 aa)
TMEM189Transmembrane protein 189. (296 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
PSMA7Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (358 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (289 aa)
LRRC34Leucine rich repeat containing 34. (513 aa)
HMGB1Uncharacterized protein. (233 aa)
LRRC74ALeucine rich repeat containing 74A. (505 aa)
GSDMDGasdermin D. (531 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa)
USP18Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (403 aa)
PSMB3Proteasome subunit beta. (268 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (551 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (595 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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