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| | BOK | BCL2 family apoptosis regulator BOK. (320 aa) |
| | ELANE | Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa) |
| | ENSFCAP00000057050 | Gasdermin domain-containing protein. (205 aa) |
| | DSG2 | Desmoglein 2. (1330 aa) |
| | DFFA | DNA fragmentation factor subunit alpha. (370 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CASP12 | Uncharacterized protein; Belongs to the peptidase C14A family. (527 aa) |
| | CASP4 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (495 aa) |
| | H1-1 | Histone cluster 1 H1 family member a. (214 aa) |
| | H1-6 | Histone cluster 1 H1 family member t. (211 aa) |
| | H1-5 | Histone cluster 1 H1 family member b. (226 aa) |
| | LOC101096522 | Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa) |
| | TTC6 | TPR_REGION domain-containing protein. (1880 aa) |
| | HMGB2 | High mobility group box 2. (210 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (252 aa) |
| | DBNL | Drebrin like. (522 aa) |
| | PDCD6IP | Programmed cell death 6 interacting protein. (893 aa) |
| | MAP2 | Microtubule-associated protein. (1895 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (251 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (301 aa) |
| | HMGB4 | High mobility group box 4. (193 aa) |
| | SEPTIN1 | Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (505 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | HP1BP3 | Heterochromatin protein 1 binding protein 3. (553 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa) |
| | ACIN1 | Apoptotic chromatin condensation inducer 1. (1339 aa) |
| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa) |
| | STK25 | Serine/threonine kinase 25. (426 aa) |
| | LMNB1 | Lamin B1; Belongs to the intermediate filament family. (586 aa) |
| | CAPG | Capping actin protein, gelsolin like. (388 aa) |
| | CTNNB1 | Catenin beta 1. (783 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | H1-2 | Histone cluster 1 H1 family member c. (331 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | BCAP31 | B cell receptor associated protein 31. (370 aa) |
| | H1-3 | Histone cluster 1 H1 family member d. (222 aa) |
| | TJP3 | Tight junction protein 3; Belongs to the MAGUK family. (910 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | NPVF | Neuropeptide VF precursor. (197 aa) |
| | SEPTIN4 | Septin 4. (535 aa) |
| | TEX14 | Testis expressed 14, intercellular bridge forming factor. (1483 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (287 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | DSP | Desmoplakin. (2884 aa) |
| | BMX | Tyrosine-protein kinase. (630 aa) |
| | IGDCC3 | Immunoglobulin superfamily DCC subclass member 3. (806 aa) |
| | IGDCC4 | Immunoglobulin superfamily DCC subclass member 4. (1249 aa) |
| | DFFB | DNA fragmentation factor subunit beta. (647 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (664 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (454 aa) |
| | DCC | DCC netrin 1 receptor. (1446 aa) |
| | IRF1 | Interferon regulatory factor. (322 aa) |
| | ENSFCAP00000056245 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (178 aa) |
| | AVEN | Apoptosis and caspase activation inhibitor. (356 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) |
| | CHMP7 | Charged multivesicular body protein 7. (456 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | EPPK1 | Epiplakin 1. (3436 aa) |
| | H1-4 | Histone cluster 1 H1 family member e. (218 aa) |
| | BNIP5 | BCL2 interacting protein 5. (625 aa) |
| | GSN | Gelsolin. (815 aa) |
| | CASP6 | Caspase 6; Belongs to the phospholipase A2 family. (431 aa) |
| | H1-8 | H1 histone family member O oocyte specific. (343 aa) |
| | LOC105261012 | Uncharacterized protein. (427 aa) |
| | LMNTD1 | Lamin tail domain containing 1. (497 aa) |
| | LMNB2 | Lamin B2; Belongs to the intermediate filament family. (718 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (263 aa) |
| | LMNTD2 | Lamin tail domain containing 2. (674 aa) |
| | BMF | Bcl2 modifying factor. (287 aa) |
| | TNFSF10 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (564 aa) |
| | STK24 | Serine/threonine kinase 24. (470 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | LOC101084636 | DUF4203 domain-containing protein. (350 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | CDH1 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa) |
| | OPA1 | OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa) |
| | DSG1 | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1074 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | LOC101094500 | Uncharacterized protein. (274 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (624 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | GSDMA | Gasdermin A. (445 aa) |
| | FNTA | Farnesyltransferase, CAAX box, alpha. (452 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | CHMP4B | Charged multivesicular body protein 4B. (224 aa) |
| | KPNB1 | Karyopherin subunit beta 1. (876 aa) |
| | STK26 | Serine/threonine kinase 26. (416 aa) |
| | MDP1 | Uncharacterized protein. (164 aa) |
| | M3X2M0_FELCA | Uncharacterized protein. (175 aa) |
| | DSG3 | Desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (985 aa) |
| | H1-0 | H1 histone family member 0. (231 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1. (401 aa) |
| | ADD1 | Adducin 1. (761 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (237 aa) |
| | UNC5B | Unc-5 netrin receptor B. (945 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | ENSFCAP00000026617 | Ubiquitin-like domain-containing protein. (78 aa) |
| | ENSFCAP00000026949 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (135 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (69 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa) |
| | CHMP2B | Charged multivesicular body protein 2B. (227 aa) |
| | SH3GLB2 | SH3 domain containing GRB2 like, endophilin B2. (480 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | BCL2L2 | BCL2 like 2. (193 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (247 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa) |
| | DUS4L | Uncharacterized protein. (482 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa) |
| | BCL2L10 | Uncharacterized protein. (192 aa) |
| | MAPT | Microtubule-associated protein. (778 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2289 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (523 aa) |
| | PLEC | Plectin. (4686 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa) |
| | TJP2 | Uncharacterized protein; Belongs to the MAGUK family. (1180 aa) |
| | DYNLL2 | Dynein light chain. (89 aa) |
| | SATB1 | DNA-binding protein SATB. (792 aa) |
| | APC | APC regulator of WNT signaling pathway. (2874 aa) |
| | ENSFCAP00000037707 | Uncharacterized protein. (182 aa) |
| | KXD1 | KxDL motif containing 1. (201 aa) |
| | DYNLL1 | Dynein light chain. (89 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa) |
| | CNRIP1 | Uncharacterized protein. (324 aa) |
| | LOC101098213 | Cytochrome c. (105 aa) |
| | DAPK2 | Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CHMP4A | Charged multivesicular body protein 4A. (220 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa) |
| | ENSFCAP00000033453 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa) |
| | DIABLO | Uncharacterized protein. (237 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | LOC109502223 | Ubiquitin-like domain-containing protein. (176 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | DAPK3 | Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa) |
| | NAIP | NACHT domain-containing protein. (1436 aa) |
| | GAS2 | Growth arrest specific 2. (314 aa) |
| | IRF2 | Interferon regulatory factor 2. (371 aa) |
| | OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa) |
| | CARD8 | Caspase recruitment domain family member 8. (393 aa) |
| | SPTAN1 | Spectrin alpha, non-erythrocytic 1. (2725 aa) |
| | OMA1 | OMA1 zinc metallopeptidase. (527 aa) |
| | SEPTIN5 | Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (463 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (289 aa) |
| | GSDME | Gasdermin E. (495 aa) |
| | ENSFCAP00000028410 | Uncharacterized protein. (195 aa) |
| | HMGB3 | Uncharacterized protein. (271 aa) |
| | ENSFCAP00000027525 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CLSPN | Claspin. (1327 aa) |
| | ENSFCAP00000027328 | Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (103 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (2008 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (509 aa) |
| | NMT1 | Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (539 aa) |
| | DAPK1 | Death associated protein kinase 1. (1429 aa) |
| | SCIN | Scinderin. (715 aa) |
| | PKP1 | Plakophilin 1. (727 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | GSDMD | Gasdermin D. (531 aa) |
| | HMGB1 | Uncharacterized protein. (233 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (409 aa) |
