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SLC8A3 SLC8A3 KCNK5 KCNK5 KCNIP3 KCNIP3 FAHD2A FAHD2A ENSFCAP00000060347 ENSFCAP00000060347 FXYD2 FXYD2 KCNJ4 KCNJ4 NPR2 NPR2 ATP1A4 ATP1A4 RYR1 RYR1 SCN4A SCN4A CACNA2D2 CACNA2D2 ATP1B2 ATP1B2 TRDN TRDN RPS14 RPS14 KCNA5 KCNA5 NPPA NPPA CALM3 CALM3 CLIC2 CLIC2 FXYD1 FXYD1 RYR2 RYR2 KCND1 KCND1 KCNK4 KCNK4 FXYD7 FXYD7 SCN3A SCN3A KCNK13 KCNK13 KCNIP4 KCNIP4 MME MME CALM1 CALM1 KCNJ2 KCNJ2 FXYD3 FXYD3 ATP2A3 ATP2A3 KCNK12 KCNK12 FXYD4 FXYD4 KCNK3 KCNK3 CACNG6 CACNG6 KCNH2 KCNH2 KCNIP1 KCNIP1 ENSFCAP00000046742 ENSFCAP00000046742 KCNK6 KCNK6 KCNK9 KCNK9 SCN4B SCN4B KCNQ1 KCNQ1 FXYD5 FXYD5 ATP2A1 ATP2A1 ORAI3 ORAI3 CACNB2 CACNB2 SCN7A SCN7A KCNK15 KCNK15 SLC8A1 SLC8A1 KCNJ12 KCNJ12 FKBP1B FKBP1B SCN3B SCN3B KCNJ14 KCNJ14 KCNE5 KCNE5 FGF14 FGF14 CACNA2D1 CACNA2D1 MAST1 MAST1 SCN5A SCN5A KCNE4 KCNE4 ATP1A1 ATP1A1 CASQ1 CASQ1 SCN1A SCN1A ATP2B4 ATP2B4 KCNK18 KCNK18 CACNG4 CACNG4 SCN2A SCN2A CAMK2G CAMK2G ENSFCAP00000029012 ENSFCAP00000029012 LOC101097703 LOC101097703 ATP2B2 ATP2B2 CALML3 CALML3 SCN10A SCN10A CACNB1 CACNB1 ASPH ASPH BGN BGN FELCATV1R2 FELCATV1R2 FGF11 FGF11 CASQ2 CASQ2 ORAI2 ORAI2 ATP2A2 ATP2A2 ORAI1 ORAI1 KCNK17 KCNK17 SLC8A2 SLC8A2 FGF12 FGF12 RYR3 RYR3 CACNG5 CACNG5 NOS1 NOS1 M3X2R5_FELCA M3X2R5_FELCA STIM2 STIM2 CACNG8 CACNG8 MAST4 MAST4 M3WZ61_FELCA M3WZ61_FELCA ATP1B3 ATP1B3 TRPC1 TRPC1 SRI SRI PRKACA PRKACA KCNK2 KCNK2 PHEX PHEX FGF13 FGF13 RANGRF RANGRF M3WQU5_FELCA M3WQU5_FELCA CALM2 CALM2 ASPHD2 ASPHD2 MAST2 MAST2 ASPHD1 ASPHD1 ITPR3 ITPR3 KCNIP2 KCNIP2 ATP1A3 ATP1A3 NPPC NPPC ABCC9 ABCC9 FXYD6 FXYD6 MMEL1 MMEL1 ATP1B1 ATP1B1 KCNE3 KCNE3 KCND2 KCND2 STIM1 STIM1 ATP2B1 ATP2B1 MAST3 MAST3 DMPK DMPK KCNJ11 KCNJ11 KCNE1 KCNE1 KCNE2 KCNE2 KCNK1 KCNK1 KCNK16 KCNK16 SDR42E2 SDR42E2 CORIN CORIN KCNK7 KCNK7 PLN PLN AHCYL1 AHCYL1 SCN8A SCN8A ITPR2 ITPR2 NPR1 NPR1 KCND3 KCND3 ITPR1 ITPR1 CACNG7 CACNG7 KCNK10 KCNK10 SCN9A SCN9A NKX2-5 NKX2-5 SCN11A SCN11A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
KCNK5Potassium two pore domain channel subfamily K member 5. (538 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (308 aa)
FAHD2AFumarylacetoacetate hydrolase domain containing 2A. (318 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (457 aa)
NPR2Guanylate cyclase. (1057 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1074 aa)
RYR1Ryanodine receptor 1. (5041 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1880 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
TRDNTriadin. (721 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (567 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
CLIC2Chloride intracellular channel 2. (284 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
RYR2Ryanodine receptor 2. (4967 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (652 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (531 aa)
FXYD7FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (289 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
KCNK13Potassium two pore domain channel subfamily K member 13; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (444 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (250 aa)
MMEMembrane metalloendopeptidase. (749 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (454 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa)
KCNK12Potassium two pore domain channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (430 aa)
FXYD4FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (89 aa)
KCNK3Potassium channel subfamily K member. (401 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (262 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1167 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (232 aa)
ENSFCAP00000046742FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
KCNK6Potassium channel subfamily K member. (353 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (505 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (692 aa)
FXYD5FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (223 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (276 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (632 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1679 aa)
KCNK15Potassium two pore domain channel subfamily K member 15; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (330 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (973 aa)
KCNJ12Uncharacterized protein. (535 aa)
FKBP1BPeptidylprolyl isomerase. (238 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (295 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (432 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (137 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (303 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1571 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (175 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1038 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa)
KCNK18Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (387 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1957 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (702 aa)
ASPHAspartate beta-hydroxylase. (692 aa)
BGNCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1485 aa)
FELCATV1R2Vomeronasal type-1 receptor. (300 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (290 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (254 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
KCNK17Potassium channel subfamily K member. (344 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
RYR3Ryanodine receptor 3. (4859 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (324 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
M3X2R5_FELCAGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (170 aa)
STIM2Stromal interaction molecule 2. (840 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (422 aa)
MAST4Uncharacterized protein. (1369 aa)
M3WZ61_FELCAVomeronasal type-1 receptor. (309 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
SRISorcin. (247 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
RANGRFUncharacterized protein. (186 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
ASPHD2Aspartate beta-hydroxylase domain containing 2. (343 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1799 aa)
ASPHD1Aspartate beta-hydroxylase domain containing 1. (367 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
NPPCNatriuretic peptide C. (193 aa)
ABCC9ATP binding cassette subfamily C member 9. (1548 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (111 aa)
MMEL1Membrane metalloendopeptidase like 1. (818 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
STIM1Stromal interaction molecule 1. (799 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1302 aa)
DMPKDM1 protein kinase. (801 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (132 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (182 aa)
KCNK1Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (572 aa)
KCNK16Potassium two pore domain channel subfamily K member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (294 aa)
SDR42E2Short chain dehydrogenase/reductase family 42E, member 2. (413 aa)
CORINCorin, serine peptidase. (1045 aa)
KCNK7Potassium two pore domain channel subfamily K member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (307 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
NPR1Guanylate cyclase. (1063 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
KCNK10Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (538 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
NKX2-5NK2 homeobox 5. (333 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1784 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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