STRINGSTRING
ITPR1 ITPR1 ITPR2 ITPR2 AHCYL1 AHCYL1 PLN PLN SDR42E2 SDR42E2 KCNJ11 KCNJ11 DMPK DMPK ATP2B1 ATP2B1 STIM1 STIM1 ATP1B1 ATP1B1 FXYD6 FXYD6 ABCC9 ABCC9 ATP1A3 ATP1A3 ITPR3 ITPR3 ASPHD1 ASPHD1 ASPHD2 ASPHD2 CALM2 CALM2 M3WQU5_FELCA M3WQU5_FELCA PRKACA PRKACA SRI SRI TRPC1 TRPC1 FXYD2 FXYD2 ATP1B3 ATP1B3 M3WZ61_FELCA M3WZ61_FELCA STIM2 STIM2 NOS1 NOS1 RYR3 RYR3 SLC8A2 SLC8A2 ORAI1 ORAI1 ATP2A2 ATP2A2 ENSFCAP00000060347 ENSFCAP00000060347 ORAI2 ORAI2 CASQ2 CASQ2 FELCATV1R2 FELCATV1R2 BGN BGN ASPH ASPH CALML3 CALML3 ATP2B2 ATP2B2 LOC101097703 LOC101097703 ENSFCAP00000029012 ENSFCAP00000029012 CAMK2G CAMK2G ATP2B4 ATP2B4 CASQ1 CASQ1 ATP1A1 ATP1A1 SLC8A3 SLC8A3 FKBP1B FKBP1B SLC8A1 SLC8A1 ORAI3 ORAI3 ATP2A1 ATP2A1 FXYD5 FXYD5 ENSFCAP00000046742 ENSFCAP00000046742 FXYD4 FXYD4 ATP2A3 ATP2A3 FXYD3 FXYD3 CALM1 CALM1 FXYD7 FXYD7 RYR2 RYR2 FXYD1 FXYD1 CLIC2 CLIC2 CALM3 CALM3 RPS14 RPS14 TRDN TRDN ATP1B2 ATP1B2 RYR1 RYR1 ATP1A4 ATP1A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SDR42E2Short chain dehydrogenase/reductase family 42E, member 2. (413 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
DMPKDM1 protein kinase. (801 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
STIM1Stromal interaction molecule 1. (799 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (111 aa)
ABCC9ATP binding cassette subfamily C member 9. (1548 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ASPHD1Aspartate beta-hydroxylase domain containing 1. (367 aa)
ASPHD2Aspartate beta-hydroxylase domain containing 2. (343 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
M3WQU5_FELCAEF-hand domain-containing protein; Belongs to the calmodulin family. (77 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SRISorcin. (247 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
M3WZ61_FELCAVomeronasal type-1 receptor. (309 aa)
STIM2Stromal interaction molecule 2. (840 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
RYR3Ryanodine receptor 3. (4859 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
ENSFCAP00000060347Uncharacterized protein; Belongs to the calmodulin family. (146 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (254 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (409 aa)
FELCATV1R2Vomeronasal type-1 receptor. (300 aa)
BGNCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1485 aa)
ASPHAspartate beta-hydroxylase. (692 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ENSFCAP00000029012Uncharacterized protein; Belongs to the calmodulin family. (124 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (494 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1038 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
FKBP1BPeptidylprolyl isomerase. (238 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (973 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (276 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
FXYD5FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (223 aa)
ENSFCAP00000046742FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
FXYD4FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (89 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (192 aa)
FXYD7FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (289 aa)
RYR2Ryanodine receptor 2. (4967 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
CLIC2Chloride intracellular channel 2. (284 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (276 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
TRDNTriadin. (721 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
RYR1Ryanodine receptor 1. (5041 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1074 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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