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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (931 aa) |
| | MBD3 | Methyl-CpG binding domain protein 3. (301 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | EHMT1 | Euchromatic histone lysine methyltransferase 1. (1312 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1241 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (558 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (801 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | PML | Promyelocytic leukemia. (876 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (749 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (678 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TTC5 | Tetratricopeptide repeat domain 5. (505 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (606 aa) |
| | DAXX | Death domain associated protein. (748 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (344 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | L3MBTL1 | SAM domain-containing protein. (914 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa) |
| | BLM | BLM RecQ like helicase. (1428 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (618 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1947 aa) |
| | CHD4 | Uncharacterized protein. (1912 aa) |
| | TBP | TATA-box binding protein. (327 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | AIRE | Autoimmune regulator. (549 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (630 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | ZNF385A | Zinc finger protein 385A. (386 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (773 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (749 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (869 aa) |
| | BANP | BTG3 associated nuclear protein. (528 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa) |
| | EXO1 | Exonuclease 1. (946 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | RFC4 | Replication factor C subunit 4. (389 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | RMI1 | RecQ mediated genome instability 1. (635 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1311 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (239 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (864 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (298 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (211 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (988 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (489 aa) |
| | WRN | WRN RecQ like helicase. (1406 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (404 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa) |
| | LY6G5B | Lymphocyte antigen 6 family member G5B. (216 aa) |
| | PHF20 | PHD finger protein 20. (1013 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (260 aa) |
| | ING1 | Inhibitor of growth protein. (279 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | L3MBTL4 | L3MBTL histone methyl-lysine binding protein 4. (614 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (278 aa) |
| | ENSFCAP00000026617 | Ubiquitin-like domain-containing protein. (78 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (326 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1222 aa) |
| | LOC101092829 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (165 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (987 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1092 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | TAF13 | TATA-box binding protein associated factor 13. (124 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (421 aa) |
| | FOXP4 | Forkhead box P4. (686 aa) |
| | TBPL2 | TATA-box binding protein like 2. (361 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa) |
| | LOC109502223 | Ubiquitin-like domain-containing protein. (176 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (473 aa) |
| | HDAC2 | Histone deacetylase 2. (602 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2057 aa) |
| | TXNDC11 | Thioredoxin domain containing 11. (961 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | BRPF1 | Bromodomain and PHD finger containing 1. (1220 aa) |
| | CEP170 | Centrosomal protein 170. (1588 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (748 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1289 aa) |
| | KXD1 | KxDL motif containing 1. (201 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | ZNF385B | Zinc finger protein 385B. (489 aa) |
| | PRDM1 | PR/SET domain 1. (821 aa) |
| | RNF34 | Ring finger protein 34. (382 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (637 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | TAF7 | TATA-box binding protein associated factor 7. (349 aa) |
| | MAPKAP1 | MAPK associated protein 1. (575 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (200 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (641 aa) |
| | BRD1 | Bromodomain containing 1. (1233 aa) |
| | RMI2 | RecQ mediated genome instability 2. (153 aa) |
| | C17orf113 | Chromosome 17 open reading frame 113. (675 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | CDK5R2 | Cyclin-dependent kinase 5 activator. (370 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa) |
| | PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2060 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2012 aa) |
| | PRR5 | Proline rich 5. (389 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa) |
| | SETD9 | SET domain containing 9. (299 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | CHEK2 | Checkpoint kinase 2. (569 aa) |
| | TP53RK | TP53 regulating kinase. (253 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1906 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | L3MBTL3 | L3MBTL histone methyl-lysine binding protein 3. (780 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | LOC101093046 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (208 aa) |
| | NUAK1 | NUAK family kinase 1. (667 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1732 aa) |
| | DAXX-2 | Daxx domain-containing protein. (769 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (408 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1251 aa) |
| | PPP1R13L | Protein phosphatase 1 regulatory subunit 13 like. (867 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (652 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (598 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (591 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1221 aa) |
| | AK6 | Adenylate kinase 6. (268 aa) |
| | BRD9 | Bromodomain containing 9. (1016 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (584 aa) |
| | RFC2 | Replication factor C subunit 2. (387 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1211 aa) |
| | ENSFCAP00000055099 | Uncharacterized protein. (115 aa) |
| | KMT5A | Lysine methyltransferase 5A. (500 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (726 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (1099 aa) |
| | ZNF385C | Zinc finger protein 385C. (542 aa) |
| | SMYD2 | SET domain-containing protein. (532 aa) |
| | GATAD2A | GATA zinc finger domain containing 2A. (756 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (772 aa) |
| | RFFL | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (528 aa) |
| | ENSFCAP00000058884 | Protein kinase domain-containing protein. (375 aa) |
| | ING5 | Inhibitor of growth family member 5. (293 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | NUAK2 | NUAK family kinase 2. (647 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (435 aa) |
| | ENSFCAP00000060774 | Protein kinase domain-containing protein. (78 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1551 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1407 aa) |
| | ENSFCAP00000061684 | Uncharacterized protein. (410 aa) |
| | ARHGAP8 | Uncharacterized protein. (573 aa) |
