STRINGSTRING
VCPIP1 VCPIP1 RIPK1 RIPK1 CDK1 CDK1 PTEN PTEN SPATA5L1 SPATA5L1 RIPK2 RIPK2 GUF1 GUF1 TNFAIP3 TNFAIP3 OTUD5 OTUD5 UBE2D1 UBE2D1 OTUB2 OTUB2 TRAF6 TRAF6 TP53 TP53 APC2 APC2 APC APC NOD1 NOD1 KXD1 KXD1 TRAF3 TRAF3 LOC109502223 LOC109502223 ZRANB1 ZRANB1 NOD2 NOD2 VCP VCP M3WAV2_FELCA M3WAV2_FELCA IKBKG IKBKG ESR1 ESR1 RPS27A RPS27A UBA52 UBA52 OTUD7B OTUD7B RNF13 RNF13 ENSFCAP00000060774 ENSFCAP00000060774 OTUD7A OTUD7A TRAF5 TRAF5 TNIP2 TNIP2 ENSFCAP00000026617 ENSFCAP00000026617 OTUD4 OTUD4 OTUB1 OTUB1 OTUD3 OTUD3 RNF167 RNF167 ZNRF4 ZNRF4 TNIP3 TNIP3 TNIP1 TNIP1 SPATA5 SPATA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCPIP1Valosin containing protein interacting protein 1. (1223 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SPATA5L1Spermatogenesis associated 5 like 1. (767 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
TNFAIP3TNF alpha induced protein 3. (804 aa)
OTUD5OTU deubiquitinase 5. (583 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
OTUB2Ubiquitin thioesterase. (314 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
APC2APC regulator of WNT signaling pathway 2. (2289 aa)
APCAPC regulator of WNT signaling pathway. (2874 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
KXD1KxDL motif containing 1. (201 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (761 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (761 aa)
M3WAV2_FELCARING-type domain-containing protein. (222 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
RPS27ARibosomal protein S27a. (156 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
OTUD7BOTU deubiquitinase 7B. (842 aa)
RNF13Ring finger protein 13. (381 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
OTUD7AOTU deubiquitinase 7A. (941 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNIP2TNFAIP3 interacting protein 2. (436 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
OTUD4OTU deubiquitinase 4. (1107 aa)
OTUB1Ubiquitin thioesterase. (281 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
RNF167Ring finger protein 167. (366 aa)
ZNRF4RING-type domain-containing protein. (453 aa)
TNIP3TNFAIP3 interacting protein 3. (397 aa)
TNIP1TNFAIP3 interacting protein 1. (635 aa)
SPATA5Spermatogenesis associated 5. (935 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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