STRINGSTRING
UBA52 UBA52 MAPKAP1 MAPKAP1 USP2 USP2 ARHGAP8 ARHGAP8 MTOR MTOR PDPK1 PDPK1 AKT3 AKT3 PPP2R1A PPP2R1A DAXX DAXX CCNA1 CCNA1 AKT1 AKT1 CDK3 CDK3 MDM4 MDM4 CDK1 CDK1 PPP2R5C PPP2R5C RPS27A RPS27A CCNG1 CCNG1 CCNA2 CCNA2 PPP2CA PPP2CA KXD1 KXD1 CEP170 CEP170 TXNDC11 TXNDC11 USP7 USP7 LOC109502223 LOC109502223 CDK2 CDK2 MLST8 MLST8 ENSFCAP00000026617 ENSFCAP00000026617 ATM ATM MDM2 MDM2 PHF20 PHF20 PPP2CB PPP2CB PRR5 PRR5 TP53 TP53 RICTOR RICTOR DAXX-2 DAXX-2 SGK1 SGK1 PPP2R1B PPP2R1B RFFL RFFL AKT2 AKT2 ENSFCAP00000060774 ENSFCAP00000060774 PRDM1 PRDM1 RNF34 RNF34
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
MAPKAP1MAPK associated protein 1. (575 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
ARHGAP8Uncharacterized protein. (573 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
DAXXDeath domain associated protein. (748 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
RPS27ARibosomal protein S27a. (156 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
KXD1KxDL motif containing 1. (201 aa)
CEP170Centrosomal protein 170. (1588 aa)
TXNDC11Thioredoxin domain containing 11. (961 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
PHF20PHD finger protein 20. (1013 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PRR5Proline rich 5. (389 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
DAXX-2Daxx domain-containing protein. (769 aa)
SGK1Non-specific serine/threonine protein kinase. (584 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (528 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
PRDM1PR/SET domain 1. (821 aa)
RNF34Ring finger protein 34. (382 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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