STRINGSTRING
PSMB6 PSMB6 PSMD6 PSMD6 PSMC2 PSMC2 PSMD8 PSMD8 PSMC4 PSMC4 PSMD5 PSMD5 POLA2 POLA2 CCNE1 CCNE1 PSMB4 PSMB4 POLA1 POLA1 ORC1 ORC1 PSMD13 PSMD13 PSMC5 PSMC5 MCM7 MCM7 AKT3 AKT3 PPP2R1A PPP2R1A OPTN OPTN PPP4R1 PPP4R1 CCNA1 CCNA1 CDK7 CDK7 AKT1 AKT1 PSME1 PSME1 CDK3 CDK3 RPA1 RPA1 TM4SF19 TM4SF19 PSMD2 PSMD2 ORC3 ORC3 CDC25A CDC25A POLE2 POLE2 UBA52 UBA52 PPP4R4 PPP4R4 MCM4 MCM4 PSMA1 PSMA1 MCM8 MCM8 PSMB10 PSMB10 MCM6 MCM6 FNBP4 FNBP4 RELCH RELCH MCM5 MCM5 PSMB7 PSMB7 WEE2 WEE2 LOC101092674 LOC101092674 PSMD9 PSMD9 GMNN GMNN PPP2R3B PPP2R3B ORC2 ORC2 CKS2 CKS2 PSMD7 PSMD7 PSMA6 PSMA6 RPS27A RPS27A KIAA2012 KIAA2012 CCNA2 CCNA2 MCM3 MCM3 CDKN1A CDKN1A DBF4 DBF4 PPP2CB PPP2CB LOC101083848 LOC101083848 PSMD12 PSMD12 PSMD10 PSMD10 CCNE2 CCNE2 CDC7 CDC7 CDC6 CDC6 PSMD11 PSMD11 PSMA2 PSMA2 CUL1 CUL1 POLE3 POLE3 PPP2R3C PPP2R3C RB1 RB1 PRIM2 PRIM2 MCM9 MCM9 LOC101083171 LOC101083171 ORC6 ORC6 ENSFCAP00000026617 ENSFCAP00000026617 ENSFCAP00000026978 ENSFCAP00000026978 CKS1B CKS1B MEIOB MEIOB MCM2 MCM2 ORC5 ORC5 RPA2 RPA2 CDK2 CDK2 LOC109502223 LOC109502223 RPA3 RPA3 PSMA5 PSMA5 PRIM1 PRIM1 PSMF1 PSMF1 PSMC1 PSMC1 CEP170 CEP170 ENSFCAP00000036869 ENSFCAP00000036869 CDC45 CDC45 ENSFCAP00000037196 ENSFCAP00000037196 KXD1 KXD1 POLE4 POLE4 PPP2CA PPP2CA PPP2R3A PPP2R3A LOC111556170 LOC111556170 LOC111556171 LOC111556171 ENSFCAP00000041674 ENSFCAP00000041674 PSMC3 PSMC3 PSMD14 PSMD14 CDKN1C CDKN1C CDKN1B CDKN1B ORC4 ORC4 PSMA4 PSMA4 LOC101082405 LOC101082405 ENSFCAP00000048496 ENSFCAP00000048496 PSMD4 PSMD4 PSMB5 PSMB5 MNAT1 MNAT1 POLE POLE CABLES1 CABLES1 PSMD1 PSMD1 PSME2 PSME2 CCND1 CCND1 PSME3 PSME3 PSMB1 PSMB1 ENSFCAP00000053469 ENSFCAP00000053469 PSMA3 PSMA3 CDT1 CDT1 ENSFCAP00000055272 ENSFCAP00000055272 PPP2R1B PPP2R1B WEE1 WEE1 CCNH CCNH PSMB2 PSMB2 PSMC6 PSMC6 PSMB3 PSMB3 AKT2 AKT2 SKP2 SKP2 SKP1 SKP1 PSMD3 PSMD3 ENSFCAP00000061455 ENSFCAP00000061455 ENSFCAP00000061943 ENSFCAP00000061943
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB6Proteasome subunit beta. (239 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (478 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (355 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
POLA1DNA polymerase. (1468 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (851 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
OPTNOptineurin. (874 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (949 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSME1Proteasome activator subunit 1. (249 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (618 aa)
TM4SF19Uncharacterized protein. (209 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
CDC25ACell division cycle 25A. (524 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (874 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (833 aa)
PSMB10Proteasome subunit beta. (273 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
FNBP4Formin binding protein 4. (1020 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1222 aa)
MCM5Minichromosome maintenance complex component 5; Belongs to the MCM family. (907 aa)
PSMB7Proteasome subunit beta. (277 aa)
WEE2Wee1-like protein kinase. (568 aa)
LOC101092674WRNPLPNID domain-containing protein. (951 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (284 aa)
GMNNGeminin DNA replication inhibitor. (210 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (579 aa)
ORC2Origin recognition complex subunit 2. (602 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
RPS27ARibosomal protein S27a. (156 aa)
KIAA2012Uncharacterized protein. (1180 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
DBF4DBF4 zinc finger. (676 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC101083848Proteasome subunit beta. (209 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
CDC7Cell division cycle 7. (574 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
RB1RB transcriptional corepressor 1. (930 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (562 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
LOC101083171Proteasome subunit beta. (276 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
ENSFCAP00000026978Uncharacterized protein. (111 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
MCM2DNA helicase; Belongs to the MCM family. (929 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
RPA2Replication protein A2. (270 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
RPA3Replication protein A3. (121 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
PSMF1Proteasome inhibitor subunit 1. (341 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
CEP170Centrosomal protein 170. (1588 aa)
ENSFCAP00000036869Proteasome subunit alpha type. (197 aa)
CDC45Cell division cycle 45. (567 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
KXD1KxDL motif containing 1. (201 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
LOC111556170Proteasome subunit beta type-8. (276 aa)
LOC111556171Uncharacterized protein. (234 aa)
ENSFCAP00000041674AAA domain-containing protein; Belongs to the AAA ATPase family. (189 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMA4Proteasome subunit alpha type. (277 aa)
LOC101082405AAA domain-containing protein. (330 aa)
ENSFCAP00000048496Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (423 aa)
PSMB5Proteasome subunit beta. (263 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (637 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSME2Proteasome activator subunit 2. (253 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PSME3Uncharacterized protein. (265 aa)
PSMB1Proteasome subunit beta. (261 aa)
ENSFCAP00000053469PA28_beta domain-containing protein. (192 aa)
PSMA3Proteasome subunit alpha type. (258 aa)
CDT1Chromatin licensing and DNA replication factor 1. (641 aa)
ENSFCAP00000055272Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
WEE1WEE1 G2 checkpoint kinase. (664 aa)
CCNHCyclin H; Belongs to the cyclin family. (326 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa)
PSMB3Proteasome subunit beta. (268 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (595 aa)
ENSFCAP00000061455Uncharacterized protein. (157 aa)
ENSFCAP00000061943Uncharacterized protein. (120 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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