STRINGSTRING
ENSFCAP00000055272 ENSFCAP00000055272 CCNE1 CCNE1 TFDP2 TFDP2 PPP2R1A PPP2R1A PPP4R1 PPP4R1 CDK7 CDK7 E2F1 E2F1 ABL1 ABL1 CDK3 CDK3 E2F4 E2F4 UBA52 UBA52 PPP4R4 PPP4R4 E2F2 E2F2 FNBP4 FNBP4 RELCH RELCH LOC101092674 LOC101092674 PPP2R3B PPP2R3B RBL1 RBL1 CKS2 CKS2 CDK4 CDK4 RPS27A RPS27A FNDC3A FNDC3A CDKN2D CDKN2D CDKN1A CDKN1A PPP2CB PPP2CB CCNE2 CCNE2 LYN LYN CUL1 CUL1 PPP2R3C PPP2R3C RB1 RB1 ENSFCAP00000026617 ENSFCAP00000026617 CKS1B CKS1B FNDC3B FNDC3B CDKN2C CDKN2C PPP2R2B PPP2R2B ENSFCAP00000030965 ENSFCAP00000030965 CDK2 CDK2 LOC109502223 LOC109502223 ENSFCAP00000037196 ENSFCAP00000037196 KXD1 KXD1 RBL2 RBL2 PPP2CA PPP2CA CCND3 CCND3 PPP2R3A PPP2R3A SRC SRC CCND2 CCND2 CDKN1C CDKN1C CDKN1B CDKN1B ENSFCAP00000048496 ENSFCAP00000048496 TFDP1 TFDP1 CDK6 CDK6 MNAT1 MNAT1 JAK2 JAK2 PPP2R2A PPP2R2A CCND1 CCND1 ENSFCAP00000052091 ENSFCAP00000052091 PPP2R1B PPP2R1B CCNH CCNH SKP2 SKP2 SKP1 SKP1 CA13 CA13 E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSFCAP00000055272Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
TFDP2Transcription factor. (386 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (949 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
E2F1E2F transcription factor 1. (436 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa)
E2F4E2F transcription factor 4. (406 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (874 aa)
E2F2E2F transcription factor 2. (442 aa)
FNBP4Formin binding protein 4. (1020 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1222 aa)
LOC101092674WRNPLPNID domain-containing protein. (951 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (579 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
RPS27ARibosomal protein S27a. (156 aa)
FNDC3AFibronectin type III domain containing 3A. (1199 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
LYNTyrosine-protein kinase. (526 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
RB1RB transcriptional corepressor 1. (930 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (583 aa)
ENSFCAP00000030965Protein kinase domain-containing protein. (104 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
KXD1KxDL motif containing 1. (201 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
SRCTyrosine-protein kinase. (678 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
ENSFCAP00000048496Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
TFDP1Transcription factor. (423 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
ENSFCAP00000052091Uncharacterized protein. (1125 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
CCNHCyclin H; Belongs to the cyclin family. (326 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
CA13Carbonic anhydrase 13. (534 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.