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| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (464 aa) |
| | CDC25A | Cell division cycle 25A. (524 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (1031 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (573 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1893 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (618 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (376 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (851 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | RFC1 | Replication factor C subunit 1. (1143 aa) |
| | CDC23 | Cell division cycle 23. (547 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (355 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (478 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | PSMA1 | Proteasome subunit alpha type. (263 aa) |
| | MCM8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (833 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (232 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | MCM5 | Minichromosome maintenance complex component 5; Belongs to the MCM family. (907 aa) |
| | RFC4 | Replication factor C subunit 4. (389 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (602 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | WEE2 | Wee1-like protein kinase. (568 aa) |
| | TCERG1L | Transcription elongation regulator 1 like. (590 aa) |
| | PSMD9 | Proteasome 26S subunit, non-ATPase 9. (284 aa) |
| | PSMB11 | Proteasome subunit beta. (276 aa) |
| | GMNN | Geminin DNA replication inhibitor. (210 aa) |
| | ORC2 | Origin recognition complex subunit 2. (602 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | PSMA6 | Proteasome subunit alpha type. (251 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (555 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | PDS5A | PDS5 cohesin associated factor A. (1337 aa) |
| | KIAA2012 | Uncharacterized protein. (1180 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | LOC101083848 | Proteasome subunit beta. (209 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (406 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (829 aa) |
| | CDCA5 | Cell division cycle associated 5. (252 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (562 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | LOC101083171 | Proteasome subunit beta. (276 aa) |
| | TM7SF3 | Transmembrane 7 superfamily member 3. (570 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1943 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | ENSFCAP00000026617 | Ubiquitin-like domain-containing protein. (78 aa) |
| | ENSFCAP00000026963 | Uncharacterized protein. (73 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | ENSFCAP00000026978 | Uncharacterized protein. (111 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | ESCO1 | Establishment of sister chromatid cohesion N-acetyltransferase 1. (847 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | ENSFCAP00000030965 | Protein kinase domain-containing protein. (104 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | LOC109502223 | Ubiquitin-like domain-containing protein. (176 aa) |
| | PDS5B | PDS5 cohesin associated factor B. (1448 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (110 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (341 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (125 aa) |
| | PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | CEP170 | Centrosomal protein 170. (1588 aa) |
| | ENSFCAP00000036869 | Proteasome subunit alpha type. (197 aa) |
| | ENSFCAP00000037196 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa) |
| | WAPL | WAPL cohesin release factor. (1196 aa) |
| | KXD1 | KxDL motif containing 1. (201 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | LOC111556170 | Proteasome subunit beta type-8. (276 aa) |
| | LOC111556171 | Uncharacterized protein. (234 aa) |
| | ENSFCAP00000041674 | AAA domain-containing protein; Belongs to the AAA ATPase family. (189 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (182 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (812 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (264 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (192 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (252 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PSMA4 | Proteasome subunit alpha type. (277 aa) |
| | PSME4 | Proteasome activator subunit 4. (1865 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | LOC101082405 | AAA domain-containing protein. (330 aa) |
| | ENSFCAP00000048496 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (423 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | CABLES1 | Cdk5 and Abl enzyme substrate 1. (637 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | PSME2 | Proteasome activator subunit 2. (253 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | PSME3 | Uncharacterized protein. (265 aa) |
| | STAG1 | Stromal antigen 1. (1299 aa) |
| | GINS1 | GINS complex subunit 1. (204 aa) |
| | CDC27 | Cell division cycle 27. (839 aa) |
| | PSMB1 | Proteasome subunit beta. (261 aa) |
| | ENSFCAP00000053469 | PA28_beta domain-containing protein. (192 aa) |
| | ENSFCAP00000053720 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (114 aa) |
| | ENSFCAP00000053797 | Uncharacterized protein. (91 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | PSMA3 | Proteasome subunit alpha type. (258 aa) |
| | RFC2 | Replication factor C subunit 2. (387 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (641 aa) |
| | ENSFCAP00000055272 | Uncharacterized protein; Belongs to the SKP1 family. (147 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (257 aa) |
| | PSMA7 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (358 aa) |
| | WEE1 | WEE1 G2 checkpoint kinase. (664 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (326 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa) |
| | PSMB3 | Proteasome subunit beta. (268 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | SKP2 | S-phase kinase associated protein 2. (451 aa) |
| | SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (168 aa) |
| | LIG1 | DNA ligase. (913 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (595 aa) |
| | ENSFCAP00000061455 | Uncharacterized protein. (157 aa) |
| | CDC25B | Cell division cycle 25B. (578 aa) |
| | ENSFCAP00000061943 | Uncharacterized protein. (120 aa) |
