STRINGSTRING
EXO1 EXO1 RFC4 RFC4 RMI1 RMI1 CDK1 CDK1 CHEK1 CHEK1 ENSFCAP00000057801 ENSFCAP00000057801 ENSFCAP00000058369 ENSFCAP00000058369 ENSFCAP00000058502 ENSFCAP00000058502 WEE2 WEE2 ATR ATR RAD50 RAD50 EXD2 EXD2 RBBP8 RBBP8 WRN WRN TDRD3 TDRD3 YWHAZ YWHAZ CDC25C CDC25C LOC101092488 LOC101092488 RFC3 RFC3 MRE11 MRE11 SLF1 SLF1 RHNO1 RHNO1 ATM ATM ENSFCAP00000026949 ENSFCAP00000026949 ENSFCAP00000028809 ENSFCAP00000028809 YWHAG YWHAG MEIOB MEIOB RAD1 RAD1 TOP3A TOP3A LOC101093034 LOC101093034 RPA2 RPA2 ENSFCAP00000033453 ENSFCAP00000033453 RPA3 RPA3 KAT5 KAT5 LOC101082235 LOC101082235 RAD9A RAD9A RNF169 RNF169 RMI2 RMI2 ANKRD12 ANKRD12 TP53 TP53 ENSFCAP00000046791 ENSFCAP00000046791 CHEK2 CHEK2 YWHAH YWHAH H2BE1 H2BE1 ENSFCAP00000061058 ENSFCAP00000061058 TOPBP1 TOPBP1 ENSFCAP00000061752 ENSFCAP00000061752 ENSFCAP00000062224 ENSFCAP00000062224 ENSFCAP00000062242 ENSFCAP00000062242 ENSFCAP00000059078 ENSFCAP00000059078 YWHAQ YWHAQ ENSFCAP00000060190 ENSFCAP00000060190 SFN SFN ENSFCAP00000060774 ENSFCAP00000060774 HUS1 HUS1 YWHAE YWHAE ATRIP ATRIP H2BC3 H2BC3 NBN NBN ENSFCAP00000051919 ENSFCAP00000051919 ENSFCAP00000052534 ENSFCAP00000052534 ENSFCAP00000052612 ENSFCAP00000052612 ENSFCAP00000053311 ENSFCAP00000053311 ENSFCAP00000053436 ENSFCAP00000053436 ENSFCAP00000053438 ENSFCAP00000053438 ENSFCAP00000054141 ENSFCAP00000054141 ENSFCAP00000054710 ENSFCAP00000054710 RFC2 RFC2 ENSFCAP00000055427 ENSFCAP00000055427 ENSFCAP00000055731 ENSFCAP00000055731 RAD17 RAD17 ENSFCAP00000056234 ENSFCAP00000056234 ENSFCAP00000056245 ENSFCAP00000056245 ENSFCAP00000056893 ENSFCAP00000056893 WEE1 WEE1 ENSFCAP00000057281 ENSFCAP00000057281 RFC5 RFC5 RAD9B RAD9B BLM BLM RPA1 RPA1 BARD1 BARD1 DNA2 DNA2 YWHAB YWHAB BRCA1 BRCA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXO1Exonuclease 1. (946 aa)
RFC4Replication factor C subunit 4. (389 aa)
RMI1RecQ mediated genome instability 1. (635 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ENSFCAP00000057801Reverse transcriptase domain-containing protein. (706 aa)
ENSFCAP00000058369Reverse transcriptase domain-containing protein. (679 aa)
ENSFCAP00000058502Reverse transcriptase domain-containing protein. (846 aa)
WEE2Wee1-like protein kinase. (568 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
RAD50Zinc-hook domain-containing protein. (1311 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
RBBP8RB binding protein 8, endonuclease. (864 aa)
WRNWRN RecQ like helicase. (1406 aa)
TDRD3Tudor domain containing 3. (744 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
CDC25CCell division cycle 25C. (477 aa)
LOC101092488Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
RFC3Replication factor C subunit 3. (356 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (254 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
ENSFCAP0000002694914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (135 aa)
ENSFCAP00000028809Histone H2B; Belongs to the histone H2B family. (67 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (289 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (987 aa)
LOC101093034Uncharacterized protein. (64 aa)
RPA2Replication protein A2. (270 aa)
ENSFCAP0000003345314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
RPA3Replication protein A3. (121 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
LOC101082235Histone H2B; Belongs to the histone H2B family. (126 aa)
RAD9ARAD9 checkpoint clamp component A. (641 aa)
RNF169Ring finger protein 169. (707 aa)
RMI2RecQ mediated genome instability 2. (153 aa)
ANKRD12Ankyrin repeat domain 12. (2060 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
ENSFCAP00000046791Reverse transcriptase domain-containing protein. (1005 aa)
CHEK2Checkpoint kinase 2. (569 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (69 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSFCAP00000061058Reverse transcriptase domain-containing protein. (767 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1551 aa)
ENSFCAP00000061752Reverse transcriptase domain-containing protein. (684 aa)
ENSFCAP00000062224Reverse transcriptase domain-containing protein. (681 aa)
ENSFCAP00000062242Reverse transcriptase domain-containing protein. (739 aa)
ENSFCAP00000059078Reverse transcriptase domain-containing protein. (240 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (301 aa)
ENSFCAP00000060190Reverse transcriptase domain-containing protein. (680 aa)
SFNStratifin; Belongs to the 14-3-3 family. (252 aa)
ENSFCAP00000060774Protein kinase domain-containing protein. (78 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ATRIPATR interacting protein. (792 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (783 aa)
ENSFCAP00000051919Reverse transcriptase domain-containing protein. (739 aa)
ENSFCAP00000052534Reverse transcriptase domain-containing protein. (665 aa)
ENSFCAP00000052612Reverse transcriptase domain-containing protein. (715 aa)
ENSFCAP00000053311DUF1725 domain-containing protein. (683 aa)
ENSFCAP00000053436Reverse transcriptase domain-containing protein. (681 aa)
ENSFCAP00000053438Reverse transcriptase domain-containing protein. (740 aa)
ENSFCAP00000054141Reverse transcriptase domain-containing protein. (723 aa)
ENSFCAP00000054710Reverse transcriptase domain-containing protein. (817 aa)
RFC2Replication factor C subunit 2. (387 aa)
ENSFCAP00000055427Reverse transcriptase domain-containing protein. (365 aa)
ENSFCAP00000055731Reverse transcriptase domain-containing protein. (713 aa)
RAD17RAD17 checkpoint clamp loader component. (726 aa)
ENSFCAP00000056234Reverse transcriptase domain-containing protein. (725 aa)
ENSFCAP0000005624514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (178 aa)
ENSFCAP00000056893Reverse transcriptase domain-containing protein. (681 aa)
WEE1WEE1 G2 checkpoint kinase. (664 aa)
ENSFCAP00000057281Reverse transcriptase domain-containing protein. (867 aa)
RFC5Replication factor C subunit 5. (340 aa)
RAD9BRAD9 checkpoint clamp component B. (344 aa)
BLMBLM RecQ like helicase. (1428 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (618 aa)
BARD1BRCA1 associated RING domain 1. (773 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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