STRINGSTRING
KXD1 KXD1 KIAA2012 KIAA2012 CCNA2 CCNA2 CDKN1A CDKN1A LOC101083848 LOC101083848 PSMD12 PSMD12 PSMD10 PSMD10 CDC25B CDC25B PSMD3 PSMD3 SKP1 SKP1 SKP2 SKP2 AKT2 AKT2 PSMB3 PSMB3 PSMC6 PSMC6 PSMB2 PSMB2 CCNH CCNH WEE1 WEE1 ENSFCAP00000055272 ENSFCAP00000055272 PSMA3 PSMA3 ENSFCAP00000053469 ENSFCAP00000053469 PSMB1 PSMB1 PSME3 PSME3 CCND1 CCND1 PSME2 PSME2 PSMD1 PSMD1 CABLES1 CABLES1 FZR1 FZR1 MNAT1 MNAT1 PSMB5 PSMB5 PSMD4 PSMD4 ENSFCAP00000048496 ENSFCAP00000048496 LOC101082405 LOC101082405 PSMA4 PSMA4 CDKN1B CDKN1B CDKN1C CDKN1C PSMD14 PSMD14 PSMC3 PSMC3 ENSFCAP00000041674 ENSFCAP00000041674 LOC111556171 LOC111556171 RPS27A RPS27A PSMA6 PSMA6 PSMD7 PSMD7 CKS2 CKS2 PSMD9 PSMD9 WEE2 WEE2 PSMB7 PSMB7 PSMB10 PSMB10 PSMC5 PSMC5 PSMD13 PSMD13 PSMB4 PSMB4 CCNE1 CCNE1 PSMD5 PSMD5 PSMC4 PSMC4 PSMD8 PSMD8 PSMC2 PSMC2 PSMD6 PSMD6 PSMA1 PSMA1 UBA52 UBA52 CDC25A CDC25A PSMD2 PSMD2 LOC111556170 LOC111556170 ENSFCAP00000037196 ENSFCAP00000037196 ENSFCAP00000036869 ENSFCAP00000036869 CEP170 CEP170 PSMC1 PSMC1 CDK3 CDK3 PSME1 PSME1 PSMF1 PSMF1 AKT1 AKT1 CDK7 CDK7 CCNA1 CCNA1 AKT3 AKT3 PSMA5 PSMA5 LOC109502223 LOC109502223 CDK2 CDK2 CKS1B CKS1B ENSFCAP00000026978 ENSFCAP00000026978 PSMB6 PSMB6 ENSFCAP00000026617 ENSFCAP00000026617 LOC101083171 LOC101083171 RB1 RB1 CUL1 CUL1 PSMA2 PSMA2 PSMD11 PSMD11 CCNE2 CCNE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KXD1KxDL motif containing 1. (201 aa)
KIAA2012Uncharacterized protein. (1180 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
LOC101083848Proteasome subunit beta. (209 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
CDC25BCell division cycle 25B. (578 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (595 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PSMB3Proteasome subunit beta. (268 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa)
PSMB2Proteasome subunit beta. (201 aa)
CCNHCyclin H; Belongs to the cyclin family. (326 aa)
WEE1WEE1 G2 checkpoint kinase. (664 aa)
ENSFCAP00000055272Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMA3Proteasome subunit alpha type. (258 aa)
ENSFCAP00000053469PA28_beta domain-containing protein. (192 aa)
PSMB1Proteasome subunit beta. (261 aa)
PSME3Uncharacterized protein. (265 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PSME2Proteasome activator subunit 2. (253 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (637 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (423 aa)
ENSFCAP00000048496Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (62 aa)
LOC101082405AAA domain-containing protein. (330 aa)
PSMA4Proteasome subunit alpha type. (277 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSFCAP00000041674AAA domain-containing protein; Belongs to the AAA ATPase family. (189 aa)
LOC111556171Uncharacterized protein. (234 aa)
RPS27ARibosomal protein S27a. (156 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (284 aa)
WEE2Wee1-like protein kinase. (568 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (355 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (478 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
CDC25ACell division cycle 25A. (524 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
LOC111556170Proteasome subunit beta type-8. (276 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
ENSFCAP00000036869Proteasome subunit alpha type. (197 aa)
CEP170Centrosomal protein 170. (1588 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (420 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMF1Proteasome inhibitor subunit 1. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ENSFCAP00000026978Uncharacterized protein. (111 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
LOC101083171Proteasome subunit beta. (276 aa)
RB1RB transcriptional corepressor 1. (930 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.