72 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSN	Gelsolin. (815 aa)
	DBNL	Drebrin like. (522 aa)
	HMGB4	High mobility group box 4. (193 aa)
	HMGB1	Uncharacterized protein. (233 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (409 aa)
	H1-8	H1 histone family member O oocyte specific. (343 aa)
	LMNTD1	Lamin tail domain containing 1. (497 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (718 aa)
	MAP2	Microtubule-associated protein. (1895 aa)
	LMNTD2	Lamin tail domain containing 2. (674 aa)
	KPNA1	Importin subunit alpha; Functions in nuclear protein import. (564 aa)
	STK24	Serine/threonine kinase 24. (470 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	LOC101084636	DUF4203 domain-containing protein. (350 aa)
	CDH1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
	DSG2	Desmoglein 2. (1330 aa)
	DFFA	DNA fragmentation factor subunit alpha. (370 aa)
	DSG1	Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1074 aa)
	SH3GLB2	SH3 domain containing GRB2 like, endophilin B2. (480 aa)
	DUS4L	Uncharacterized protein. (482 aa)
	MAPT	Microtubule-associated protein. (778 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2289 aa)
	PLEC	Plectin. (4686 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1180 aa)
	SATB1	DNA-binding protein SATB. (792 aa)
	APC	APC regulator of WNT signaling pathway. (2874 aa)
	ENSFCAP00000037707	Uncharacterized protein. (182 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
	GAS2	Growth arrest specific 2. (314 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2725 aa)
	ENSFCAP00000028410	Uncharacterized protein. (195 aa)
	HMGB3	Uncharacterized protein. (271 aa)
	CLSPN	Claspin. (1327 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
	ADD1	Adducin 1. (761 aa)
	CASP6	Caspase 6; Belongs to the phospholipase A2 family. (431 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (401 aa)
	H1-0	H1 histone family member 0. (231 aa)
	DSG3	Desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (985 aa)
	M3X2M0_FELCA	Uncharacterized protein. (175 aa)
	STK26	Serine/threonine kinase 26. (416 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (452 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	DFFB	DNA fragmentation factor subunit beta. (647 aa)
	BMX	Tyrosine-protein kinase. (630 aa)
	DSP	Desmoplakin. (2884 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (910 aa)
	H1-3	Histone cluster 1 H1 family member d. (222 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	H1-5	Histone cluster 1 H1 family member b. (226 aa)
	H1-6	Histone cluster 1 H1 family member t. (211 aa)
	H1-1	Histone cluster 1 H1 family member a. (214 aa)
	SCIN	Scinderin. (715 aa)
	PKP1	Plakophilin 1. (727 aa)
	HMGB2	High mobility group box 2. (210 aa)
	BCAP31	B cell receptor associated protein 31. (370 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	H1-2	Histone cluster 1 H1 family member c. (331 aa)
	CTNNB1	Catenin beta 1. (783 aa)
	CAPG	Capping actin protein, gelsolin like. (388 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	STK25	Serine/threonine kinase 25. (426 aa)
	ACIN1	Apoptotic chromatin condensation inducer 1. (1339 aa)
	HP1BP3	Heterochromatin protein 1 binding protein 3. (553 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (479 aa)
	EPPK1	Epiplakin 1. (3436 aa)
	H1-4	Histone cluster 1 H1 family member e. (218 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACIN1	CASP3	ENSFCAP00000002152	ENSFCAP00000031946	Apoptotic chromatin condensation inducer 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.792
ACIN1	CASP7	ENSFCAP00000002152	ENSFCAP00000057656	Apoptotic chromatin condensation inducer 1.	Caspase 7; Belongs to the peptidase C14A family.	0.434
ACIN1	DFFB	ENSFCAP00000002152	ENSFCAP00000010799	Apoptotic chromatin condensation inducer 1.	DNA fragmentation factor subunit beta.	0.438
ADD1	CASP3	ENSFCAP00000024528	ENSFCAP00000031946	Adducin 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.756
APC	APC2	ENSFCAP00000039173	ENSFCAP00000041623	APC regulator of WNT signaling pathway.	APC regulator of WNT signaling pathway 2.	0.905
APC	CASP3	ENSFCAP00000039173	ENSFCAP00000031946	APC regulator of WNT signaling pathway.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.766
APC	CDH1	ENSFCAP00000039173	ENSFCAP00000049572	APC regulator of WNT signaling pathway.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.629
APC	CTNNB1	ENSFCAP00000039173	ENSFCAP00000003200	APC regulator of WNT signaling pathway.	Catenin beta 1.	0.999
APC2	APC	ENSFCAP00000041623	ENSFCAP00000039173	APC regulator of WNT signaling pathway 2.	APC regulator of WNT signaling pathway.	0.905
APC2	CASP3	ENSFCAP00000041623	ENSFCAP00000031946	APC regulator of WNT signaling pathway 2.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.559
APC2	CDH1	ENSFCAP00000041623	ENSFCAP00000049572	APC regulator of WNT signaling pathway 2.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.576
APC2	CTNNB1	ENSFCAP00000041623	ENSFCAP00000003200	APC regulator of WNT signaling pathway 2.	Catenin beta 1.	0.992
BCAP31	CASP8	ENSFCAP00000003727	ENSFCAP00000055230	B cell receptor associated protein 31.	Caspase 8; Belongs to the peptidase C14A family.	0.940
BMX	CASP3	ENSFCAP00000009736	ENSFCAP00000031946	Tyrosine-protein kinase.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.791
BMX	PTK2	ENSFCAP00000009736	ENSFCAP00000033797	Tyrosine-protein kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.422
CAPG	CASP3	ENSFCAP00000003117	ENSFCAP00000031946	Capping actin protein, gelsolin like.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.614
CAPG	CASP7	ENSFCAP00000003117	ENSFCAP00000057656	Capping actin protein, gelsolin like.	Caspase 7; Belongs to the peptidase C14A family.	0.508
CASP3	ACIN1	ENSFCAP00000031946	ENSFCAP00000002152	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Apoptotic chromatin condensation inducer 1.	0.792
CASP3	ADD1	ENSFCAP00000031946	ENSFCAP00000024528	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Adducin 1.	0.756
CASP3	APC	ENSFCAP00000031946	ENSFCAP00000039173	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	APC regulator of WNT signaling pathway.	0.766