48 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (889 aa)
	RASGRP1	RAS guanyl releasing protein 1. (877 aa)
	FGG	Fibrinogen gamma chain. (479 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)
	GP1BA	Glycoprotein Ib platelet subunit alpha. (580 aa)
	THPO	Thrombopoietin. (409 aa)
	ENSFCAP00000052091	Uncharacterized protein. (1125 aa)
	CSK	Tyrosine-protein kinase. (549 aa)
	TLNRD1	Talin rod domain containing 1. (363 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (889 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (650 aa)
	RASGRP2	RAS guanyl releasing protein 2. (615 aa)
	APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein. (659 aa)
	SRC	Tyrosine-protein kinase. (678 aa)
	SHC1	SHC adaptor protein 1. (566 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
	FGA	Fibrinogen alpha chain. (901 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (427 aa)
	COL1A1	Collagen type I alpha 1 chain. (1461 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
	TLN2	Talin 2. (2542 aa)
	FN1	Fibronectin 1. (2475 aa)
	TLN1	Talin 1. (2558 aa)
	FGB	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (473 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (662 aa)
	MPL	MPL proto-oncogene, thrombopoietin receptor. (680 aa)
	COL1A2	Collagen type I alpha 2 chain. (1367 aa)
	GP9	Glycoprotein IX platelet. (177 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1199 aa)
	ADRA2B	Adrenoceptor alpha 2B. (444 aa)
	EFS	Embryonal Fyn-associated substrate. (561 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	ADRA2C	Adrenoceptor alpha 2C. (476 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (187 aa)
	GP5	Glycoprotein V platelet. (562 aa)
	CASS4	Cas scaffold protein family member 4. (818 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	MFSD8	Major facilitator superfamily domain containing 8. (522 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2B	ADRA2C	ENSFCAP00000020451	ENSFCAP00000021814	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2C.	0.455
ADRA2C	ADRA2B	ENSFCAP00000021814	ENSFCAP00000020451	Adrenoceptor alpha 2C.	Adrenoceptor alpha 2B.	0.455
AKT1	AKT2	ENSFCAP00000004586	ENSFCAP00000059662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT1	CSK	ENSFCAP00000004586	ENSFCAP00000050368	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.435
AKT1	GRB2	ENSFCAP00000004586	ENSFCAP00000023767	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.437
AKT1	PDPK1	ENSFCAP00000004586	ENSFCAP00000001817	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.985
AKT1	SHC1	ENSFCAP00000004586	ENSFCAP00000001251	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SHC adaptor protein 1.	0.526
AKT1	SRC	ENSFCAP00000004586	ENSFCAP00000041142	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.518
AKT2	AKT1	ENSFCAP00000059662	ENSFCAP00000004586	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT2	CSK	ENSFCAP00000059662	ENSFCAP00000050368	Non-specific serine/threonine protein kinase.	Tyrosine-protein kinase.	0.443
AKT2	PDPK1	ENSFCAP00000059662	ENSFCAP00000001817	Non-specific serine/threonine protein kinase.	3-phosphoinositide dependent protein kinase 1.	0.985
AKT2	SRC	ENSFCAP00000059662	ENSFCAP00000041142	Non-specific serine/threonine protein kinase.	Tyrosine-protein kinase.	0.519
APBB1IP	BCAR1	ENSFCAP00000043627	ENSFCAP00000048172	Amyloid beta precursor protein binding family B member 1 interacting protein.	BCAR1 scaffold protein, Cas family member.	0.545
APBB1IP	CRK	ENSFCAP00000043627	ENSFCAP00000045425	Amyloid beta precursor protein binding family B member 1 interacting protein.	CRK proto-oncogene, adaptor protein.	0.617
APBB1IP	CSK	ENSFCAP00000043627	ENSFCAP00000050368	Amyloid beta precursor protein binding family B member 1 interacting protein.	Tyrosine-protein kinase.	0.461
APBB1IP	GRB2	ENSFCAP00000043627	ENSFCAP00000023767	Amyloid beta precursor protein binding family B member 1 interacting protein.	Growth factor receptor bound protein 2.	0.672
APBB1IP	ITGB3	ENSFCAP00000043627	ENSFCAP00000033446	Amyloid beta precursor protein binding family B member 1 interacting protein.	Integrin beta; Belongs to the integrin beta chain family.	0.422
APBB1IP	NEDD9	ENSFCAP00000043627	ENSFCAP00000006320	Amyloid beta precursor protein binding family B member 1 interacting protein.	Neural precursor cell expressed, developmentally down-regulated 9.	0.479
APBB1IP	PTK2	ENSFCAP00000043627	ENSFCAP00000033797	Amyloid beta precursor protein binding family B member 1 interacting protein.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.465
APBB1IP	PTPN1	ENSFCAP00000043627	ENSFCAP00000003640	Amyloid beta precursor protein binding family B member 1 interacting protein.	Tyrosine-protein phosphatase non-receptor type.	0.500