STRINGSTRING
UBA52 UBA52 SMAD6 SMAD6 SNW1 SNW1 ITGA8 ITGA8 TFDP2 TFDP2 UBE2M UBE2M CCNQ CCNQ SMAD1 SMAD1 MKX MKX PARD6A PARD6A E2F4 E2F4 STUB1 STUB1 ACVR1 ACVR1 ITGB8 ITGB8 LTBP2 LTBP2 AMHR2 AMHR2 PARP1 PARP1 NEDD8 NEDD8 TGFB1 TGFB1 TGIF2LX TGIF2LX UBE2D1 UBE2D1 PARD3 PARD3 NEDD4L NEDD4L PRKCZ PRKCZ ZFYVE16 ZFYVE16 CCNT2 CCNT2 AMH AMH ACVR2B ACVR2B CHRDL2 CHRDL2 CGN CGN SMAD2 SMAD2 TGFBR2 TGFBR2 FURIN FURIN CA13 CA13 STRAP STRAP ITGAV ITGAV SMAD5 SMAD5 CER1 CER1 PPM1A PPM1A LTBP3 LTBP3 MEN1 MEN1 PARD3B PARD3B PCSK4 PCSK4 TFDP1 TFDP1 IRX1 IRX1 CCNT1 CCNT1 CDK8 CDK8 TGFBR1 TGFBR1 ARHGEF18 ARHGEF18 NOG NOG GREM2 GREM2 ATP1B4 ATP1B4 LOC101092676 LOC101092676 DAND5 DAND5 IRX2 IRX2 IRX5 IRX5 F11R F11R SMAD7 SMAD7 SMAD9 SMAD9 BAMBI BAMBI TRIM33 TRIM33 PMEPA1 PMEPA1 LTBP1 LTBP1 CHRDL1 CHRDL1 CCNK CCNK CDK19 CDK19 INHBB INHBB FSTL1 FSTL1 BMPR1B BMPR1B ACVR2A ACVR2A KXD1 KXD1 ACVRL1 ACVRL1 SKIL SKIL LTBP4 LTBP4 WWTR1 WWTR1 MTMR4 MTMR4 MAPK3 MAPK3 SMAD3 SMAD3 ITGB5 ITGB5 FST FST ITGB3 ITGB3 NCOR1 NCOR1 HDAC1 HDAC1 LOC109502223 LOC109502223 TGFB2 TGFB2 CCNC CCNC ITGB1 ITGB1 IRX3 IRX3 MEIS3 MEIS3 FKBP1A FKBP1A SMAD4 SMAD4 BMP2 BMP2 RNF111 RNF111 IRX6 IRX6 ACVR1C ACVR1C CDK9 CDK9 USP9X USP9X ENSFCAP00000026617 ENSFCAP00000026617 BMP10 BMP10 MAPK1 MAPK1 ZFYVE9 ZFYVE9 BMPR1A BMPR1A NCOR2 NCOR2 TGIF1 TGIF1 LDLRAD4 LDLRAD4 TGIF2 TGIF2 DRAP1 DRAP1 ACVR1B ACVR1B ZCCHC4 ZCCHC4 ITGB6 ITGB6 FOXH1 FOXH1 SKI SKI SMURF2 SMURF2 IRX4 IRX4 RPS27A RPS27A CBL CBL RBL1 RBL1 JUNB JUNB SP1 SP1 FBN1 FBN1 SMURF1 SMURF1 TGFB3 TGFB3 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
SNW1SNW domain containing 1. (570 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
TFDP2Transcription factor. (386 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
CCNQCyclin Q; Belongs to the cyclin family. (376 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MKXMohawk homeobox. (454 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
E2F4E2F transcription factor 4. (406 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1823 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (483 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGIF2LXHomeobox domain-containing protein. (231 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
PARD3Par-3 family cell polarity regulator. (1417 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1246 aa)
PRKCZProtein kinase C zeta. (649 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1538 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (742 aa)
AMHAnti-Mullerian hormone. (800 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
CHRDL2Chordin like 2. (440 aa)
CGNCingulin. (1208 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (877 aa)
CA13Carbonic anhydrase 13. (534 aa)
STRAPWD_REPEATS_REGION domain-containing protein. (350 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
CER1Cerberus 1, DAN family BMP antagonist. (270 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (486 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1302 aa)
MEN1Menin 1. (749 aa)
PARD3BPar-3 family cell polarity regulator beta. (1202 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (825 aa)
TFDP1Transcription factor. (423 aa)
IRX1Iroquois homeobox 1. (485 aa)
CCNT1CYCLIN domain-containing protein; Belongs to the cyclin family. (184 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
ARHGEF18Uncharacterized protein. (1357 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (187 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
DAND5DAN domain BMP antagonist family member 5. (190 aa)
IRX2Iroquois homeobox 2. (456 aa)
IRX5Iroquois homeobox 5. (483 aa)
F11RJunctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...] (378 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (331 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1717 aa)
CHRDL1Chordin like 1. (602 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
CDK19Cyclin dependent kinase 19. (502 aa)
INHBBInhibin subunit beta B. (407 aa)
FSTL1Follistatin like 1. (328 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
KXD1KxDL motif containing 1. (201 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
SKILSKI like proto-oncogene. (686 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1656 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
MTMR4Myotubularin related protein 4. (1209 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
FSTFollistatin. (423 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
IRX3Iroquois homeobox 3. (502 aa)
MEIS3Homeobox domain-containing protein. (377 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
RNF111Ring finger protein 111. (1002 aa)
IRX6Iroquois homeobox 6. (451 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (492 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NCOR2Nuclear receptor corepressor 2. (2458 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
DRAP1DR1 associated protein 1. (212 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (513 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
FOXH1Forkhead box H1. (361 aa)
SKISKI proto-oncogene. (730 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
IRX4Iroquois homeobox 4. (520 aa)
RPS27ARibosomal protein S27a. (156 aa)
CBLCbl proto-oncogene. (902 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SP1Sp1 transcription factor. (786 aa)
FBN1Fibrillin 1. (2871 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.