STRINGSTRING
ARHGDIG ARHGDIG SHMT2 SHMT2 IQGAP2 IQGAP2 CDC42EP1 CDC42EP1 ARFGAP3 ARFGAP3 MCF2L2 MCF2L2 PLEKHG3 PLEKHG3 ARHGEF5 ARHGEF5 VRK2 VRK2 CPLX4 CPLX4 MCF2L MCF2L ANKLE2 ANKLE2 KALRN KALRN DOCK2 DOCK2 MCAM MCAM DOCK3 DOCK3 RHOG RHOG PREX1 PREX1 BCAM BCAM CDC42 CDC42 VAV1 VAV1 LAMTOR1 LAMTOR1 VAMP3 VAMP3 DOCK1 DOCK1 MPP7 MPP7 VAPB VAPB EPHA2 EPHA2 VANGL1 VANGL1 LETM1 LETM1 PIK3R1 PIK3R1 EMD EMD VAV2 VAV2 MAP3K10 MAP3K10 DOCK4 DOCK4 ARHGAP32 ARHGAP32 CYFIP1 CYFIP1 ARHGEF16 ARHGEF16 LETM2 LETM2 ARHGAP1 ARHGAP1 YKT6 YKT6 STX5 STX5 ESYT1 ESYT1 ELOVL7 ELOVL7 LEMD3 LEMD3 DIAPH3 DIAPH3 RAB7A RAB7A PAK2 PAK2 PAK4 PAK4 M3WUF4_FELCA M3WUF4_FELCA M3WUK9_FELCA M3WUK9_FELCA RBM39 RBM39 MAP3K11 MAP3K11 STBD1 STBD1 M3WW84_FELCA M3WW84_FELCA M3X271_FELCA M3X271_FELCA M3X4I6_FELCA M3X4I6_FELCA ARHGAP5 ARHGAP5 KTN1 KTN1 CDC42-2 CDC42-2 PGRMC2 PGRMC2 M3XEZ6_FELCA M3XEZ6_FELCA ITSN1 ITSN1 MAP3K9 MAP3K9 DOCK5 DOCK5 LOC101085560 LOC101085560 ARHGAP39 ARHGAP39 CAV1 CAV1 ARHGDIA ARHGDIA ELMO2 ELMO2 ITGB1 ITGB1 MAP3K21 MAP3K21 ARHGDIB ARHGDIB TFRC TFRC KIAA0355 KIAA0355 NDUFA5 NDUFA5 ENSFCAP00000036107 ENSFCAP00000036107 ENSFCAP00000037673 ENSFCAP00000037673 ARHGEF26 ARHGEF26 ENSFCAP00000038726 ENSFCAP00000038726 ENSFCAP00000039879 ENSFCAP00000039879 MPP3 MPP3 ARHGAP21 ARHGAP21 ARHGAP35 ARHGAP35 HSPE1 HSPE1 ERBIN ERBIN VAV3 VAV3 NDUFS3 NDUFS3 OPHN1 OPHN1 TRIO-2 TRIO-2 MCF2 MCF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGDIGRho GDP dissociation inhibitor gamma. (252 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
CDC42EP1CDC42 effector protein 1. (525 aa)
ARFGAP3ADP ribosylation factor GTPase activating protein 3. (525 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1055 aa)
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1458 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1522 aa)
VRK2VRK serine/threonine kinase 2. (495 aa)
CPLX4Lectin, mannose binding 1. (611 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1196 aa)
ANKLE2Ankyrin repeat and LEM domain containing 2. (1012 aa)
KALRNKalirin RhoGEF kinase. (2987 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
MCAMMelanoma cell adhesion molecule. (681 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2024 aa)
RHOGRas homolog family member G. (191 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1647 aa)
BCAMBasal cell adhesion molecule (Lutheran blood group). (628 aa)
CDC42Uncharacterized protein. (191 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
VAMP3Vesicle associated membrane protein 3. (103 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1889 aa)
MPP7Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
VAPBVAMP associated protein B and C. (243 aa)
EPHA2EPH receptor A2. (936 aa)
VANGL1Vang-like protein. (520 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (739 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
EMDEmerin. (260 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (937 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1970 aa)
ARHGAP32Rho GTPase activating protein 32. (2086 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (950 aa)
LETM2Leucine zipper and EF-hand containing transmembrane protein 2. (491 aa)
ARHGAP1Rho GTPase activating protein 1. (449 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (355 aa)
ESYT1Extended synaptotagmin 1. (1104 aa)
ELOVL7DEP domain containing 1B. (529 aa)
LEMD3LEM domain containing 3. (915 aa)
DIAPH3Diaphanous related formin 3. (1188 aa)
RAB7AUncharacterized protein. (207 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
M3WUF4_FELCAUncharacterized protein; Belongs to the GroES chaperonin family. (105 aa)
M3WUK9_FELCAUncharacterized protein. (166 aa)
RBM39RNA binding motif protein 39. (530 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (865 aa)
STBD1Starch binding domain 1. (361 aa)
M3WW84_FELCAUncharacterized protein. (87 aa)
M3X271_FELCAUncharacterized protein; Belongs to the GroES chaperonin family. (87 aa)
M3X4I6_FELCAUncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
KTN1Kinectin 1. (1330 aa)
CDC42-2Uncharacterized protein. (191 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (255 aa)
M3XEZ6_FELCAUncharacterized protein. (183 aa)
ITSN1Intersectin 1. (1721 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1102 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1863 aa)
LOC101085560Uncharacterized protein. (835 aa)
ARHGAP39Rho GTPase activating protein 39. (1102 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ARHGDIAUncharacterized protein. (425 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (1041 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
KIAA0355KIAA0355. (1069 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (117 aa)
ENSFCAP00000036107Uncharacterized protein. (72 aa)
ENSFCAP00000037673Uncharacterized protein; Belongs to the GroES chaperonin family. (99 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (870 aa)
ENSFCAP00000038726Uncharacterized protein. (134 aa)
ENSFCAP00000039879Uncharacterized protein. (148 aa)
MPP3Membrane palmitoylated protein 3; Belongs to the MAGUK family. (613 aa)
ARHGAP21Rho GTPase activating protein 21. (1950 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
HSPE1Heat shock protein family E (Hsp10) member 1; Belongs to the GroES chaperonin family. (102 aa)
ERBINErbb2 interacting protein. (1461 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (265 aa)
OPHN1Oligophrenin 1. (823 aa)
TRIO-2Uncharacterized protein. (1847 aa)
MCF2MCF.2 cell line derived transforming sequence. (1030 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.